Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Brian L. Robbins"'
Autor:
Joshua S. Baldwin, Courtney V. Fletcher, Brian L. Robbins, Anthony T. Podany, Lee C. Winchester
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 104:55-61
A novel assay using high pressure liquid chromatography (HPLC) coupled to mass spectrometer (MS) detection was developed and validated for the rifamycin anti-tuberculosis antibiotics rifampicin (RIF), rifabutin (RBT), rifapentine (RPT) and their acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88979f7c0cdb143d59cb0342a114f1f8
https://doi.org/10.1016/j.jpba.2014.11.011
https://doi.org/10.1016/j.jpba.2014.11.011
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 70:378-387
An assay using ultrahigh pressure liquid chromatography and mass spectrometry detection was developed and validated for measurement of the HIV integrase inhibitor raltegravir (MK-0518) in human cell extracts. The assay is designed to utilize 200 µl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b14f29616efc60a08becae06f72a342
https://doi.org/10.1016/j.jpba.2012.05.035
https://doi.org/10.1016/j.jpba.2012.05.035
Autor:
Jorge Pinto, M L Hughes, Rohan Hazra, Paul Palumbo, Mina Nikanjam, Barbara Heckman, Ram Yogev, Carmelita Alvero, Brian L. Robbins, Edmund V. Capparelli, Ellen G. Chadwick
Publikováno v:
Clinical Pharmacology & Therapeutics. 91:243-249
Improved antiretroviral therapies are needed for the treatment of HIV-infected infants, given the rapid progression of the disease and drug resistance resulting from perinatal exposure to antiretrovirals. We examined longitudinal pharmacokinetics (PK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1868fa8018ffe0908e8801976211942f
https://doi.org/10.1038/clpt.2011.218
https://doi.org/10.1038/clpt.2011.218
Autor:
Edmund V. Capparelli, Michael Hughes, Paul Palumbo, Ellen G. Chadwick, Rohan Hazra, Barbara Heckman, Jorge A. Pinto, Brian L. Robbins, Ram Yogev, Carmelita Alvero
Publikováno v:
AIDS. 25:643-649
To investigate the longitudinal pharmacokinetics, safety and efficacy of lopinavir/ritonavir (LPV/r) in HIV-infected infants initiating combination antiretroviral therapy (cART) between 2 weeks and 6 months of age.A prospective, open-label, multicent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e8d0ef61d133c12696fdebc88e23bd
https://doi.org/10.1097/qad.0b013e32834403f6
https://doi.org/10.1097/qad.0b013e32834403f6
Autor:
Brian L, Robbins, Edmund V, Capparelli, Ellen G, Chadwick, Ram, Yogev, Leslie, Serchuck, Carol, Worrell, Mary Elizabeth, Smith, Carmelita, Alvero, Terence, Fenton, Barbara, Heckman, Stephen I, Pelton, Grace, Aldrovandi, William, Borkowsky, John, Rodman, Peter L, Havens, Jill, Utech
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:3276-3283
Human immunodeficiency virus (HIV)-infected children and adolescents who are failing antiretrovirals may have a better virologic response when drug exposures are increased, using higher protease inhibitor doses or ritonavir boosting. We studied the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d247fb4aa9f5412f5c160b9a6f27a1d
https://doi.org/10.1128/aac.00224-08
https://doi.org/10.1128/aac.00224-08
Autor:
John H. Rodman, Leslie Serchuck, Jose F. Rodriguez, Jane C. Lindsey, Barbara Heckman, Katherine M. Knapp, Jaime Martinez, Patricia M. Flynn, Brian L. Robbins, James McNamara, Edmund V. Capparelli
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:3516-3522
Zidovudine (ZDV) and lamivudine (3TC) metabolism to triphosphates (TP) is necessary for antiviral activity. The aims of this study were to compare ZDV-TP and 3TC-TP concentrations in adolescents receiving twice daily (BID) and once daily (QD) regimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c90b633be57ca1e9ba1ef8be4431282
https://doi.org/10.1128/aac.01626-06
https://doi.org/10.1128/aac.01626-06
Publikováno v:
Journal of Chromatography B. 850:310-317
All nucleoside reverse transcriptase inhibitors (NRTI) must first be metabolized to their triphosphate forms in order to be active against HIV. Zidovudine (ZDV), abacavir (ABC) and lamivudine (3TC) have proven to be an efficacious combination. In ord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d10fe785363988463ec389f7933e3f
https://doi.org/10.1016/j.jchromb.2006.12.015
https://doi.org/10.1016/j.jchromb.2006.12.015
Autor:
Brian L. Robbins, Courtney V. Fletcher, Margaret A. Keller, Anthony T. Podany, Michael Bolaris
Publikováno v:
Journal of the Pediatric Infectious Diseases Society. 6(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641937b657968925320f8f7f347610e9
https://pubmed.ncbi.nlm.nih.gov/26803329
https://pubmed.ncbi.nlm.nih.gov/26803329
Publikováno v:
Bioanalysis. 7(12)
Background: Determination of cell-associated antiretroviral drug concentrations is necessary for research into reservoirs of HIV. Variation exists in cell-associated drug concentrations among research groups. One cause for this may be washing cells d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6031d060950a847c7548b3512ddae5d5
https://pubmed.ncbi.nlm.nih.gov/26168252
https://pubmed.ncbi.nlm.nih.gov/26168252
Autor:
Robin DiFrancesco, Joanne E. Schiffhauer, Diane T. Holland, Gene D. Morse, Kelly M. Tooley, Brian L. Robbins
Publikováno v:
The Quality Assurance Journal. 9:22-30
The goal of the AIDS Clinical Trials Group (ACTG) Pharmacology Quality Assurance (QA) Program is to provide mechanisms that assure, in a timely manner, the validity and integrity of the data produced in pharmacology-related ACTG research protocols. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79060351dea4a0847df1550912766f19
https://doi.org/10.1002/qaj.308
https://doi.org/10.1002/qaj.308