Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Brian L. Hodous"'
Autor:
Alexandra K. Gardino, Erica K. Evans, Joseph L. Kim, Natasja Brooijmans, Brian L. Hodous, Beni Wolf, Christoph Lengauer
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
Cancer genomics and mechanistic studies have revealed that heterogeneous mutations within a single kinase can result in a variety of activation mechanisms. The challenge has been to match these insights with tailored drug discovery strategies to yiel
Externí odkaz:
https://doaj.org/article/ecaaeee92c114955a1ed8fac2d8ea24c
Autor:
Richard L. Kendall, Robert Radinsky, Stephanie Geuns-Meyer, Vinod F. Patel, Isabelle Dussault, Mary Stanton, Annette Bak, Laurie B. Schenkel, Karina Romero, Philip R. Olivieri, Hanh Nho Nguyen, Brian L. Hodous, Holly L. Deak, Victor J. Cee, Sandra Ross, Patricia McElroy, Patrick Eden, Beth Ziegler, Grace Chung, Tammy L. Bush, Marc Payton
Supplementary Methods, Figures 1-5 from Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7147a5f5dbda291c8291002c611e48dd
https://doi.org/10.1158/0008-5472.22387907.v1
https://doi.org/10.1158/0008-5472.22387907.v1
Autor:
Dusica Cvetinovic Santos, Klaus Urbahns, Simone C. Zimmerli, Andreas Goutopoulos, Justin R. Potnick, Andrew Bender, Michael Meyring, Adam Shutes, Christopher Charles Victor Jones, Jared Head, Ben C. Askew, Bayard R. Huck, Ansgar Wegener, Hui Qiu, Theresa L. Johnson, Nadia Brugger, Sherer Brian A, Ngan Nguyen, Mohanraj Dhanabal, Ralf Schmidt, Roland Grenningloh, Reinaldo Jones, Richard D. Caldwell, Ariele Viacava Follis, Brian Healey, Montserrat Camps, Igor Mochalkin, Federica Morandi, Lesley Liu-Bujalski, Vikram Dutt, Brian L. Hodous, Anna Gardberg, Thomas Eichhorn
Publikováno v:
Journal of Medicinal Chemistry. 62:7643-7655
Bruton's tyrosine kinase (BTK) inhibitors such as ibrutinib hold a prominent role in the treatment of B cell malignancies. However, further refinement is needed to this class of agents, particularly in terms of adverse events (potentially driven by k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb51d59d700ed35c9b5eb75576ca2e2d
https://doi.org/10.1021/acs.jmedchem.9b00794
https://doi.org/10.1021/acs.jmedchem.9b00794
Autor:
Scott Ribich, Monique Laidlaw, Robert A. Copeland, April W. Case, Brian L. Hodous, E. Allen Sickmier, April E. Greene-Colozzi, Alexandra K. Gardino, Shane M Buker, Thomas Andrew Wynn, P. Ann Boriack-Sjodin
Publikováno v:
Molecular Cancer Therapeutics. 18:A112-A112
A variety of covalent modifications of and structural changes to RNA have been identified and demonstrated to affect RNA processing, stability and translation. The enzymes that catalyze these changes, RNA modifying proteins or RMPs, represent a large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f79b81f3cd8ab2d2cea23b5492ab0c99
https://doi.org/10.1158/1535-7163.targ-19-a112
https://doi.org/10.1158/1535-7163.targ-19-a112
Autor:
Holly L. Deak, Richard Kendall, Chaves Mary, Robert Radinsky, Grace Chung, Annette Bak, Yang Dai, Bingfan Du, Karina R. Vaida, Min-Hwa Jasmine Lin, Hanh Nho Nguyen, Brian L. Hodous, Laurie B. Schenkel, Tammy L. Bush, Patrick Eden, Paul S. Andrews, Liyue Huang, Xuhai Be, Philip R. Olivieri, Stephanie D. Geuns-Meyer, Victor J. Cee, Kelly Hanestad, Marc Payton, Jin Tang, Vinod F. Patel, Pedro J. Beltran, Beth Ziegler
Publikováno v:
Journal of Medicinal Chemistry. 58:5189-5207
Efforts to improve upon the physical properties and metabolic stability of Aurora kinase inhibitor 14a revealed that potency against multidrug-resistant cell lines was compromised by increased polarity. Despite its high in vitro metabolic intrinsic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12730d02cfac93673e41d912f0563da7
https://doi.org/10.1021/acs.jmedchem.5b00183
https://doi.org/10.1021/acs.jmedchem.5b00183
Autor:
Joseph L. Kim, Oleg Schmidt-Kittler, Yemarshet K. Gebreyohannes, Timothy Guzi, Kevin J. Wilson, Alison J. Davis, Alexandra K. Gardino, Adam Shutes, Christoph Lengauer, Lucian DiPietro, Stephen D. Miller, Brian L. Hodous, Yulian Zhang, Doug Wilson, Timothy LaBranche, Nicholas Lydon, Michael Heinrich, Nancy Kohl, Patrick Schöffski, Natasja Brooijmans, Agnieszka Wozniak, Erica Evans, Xing Julia Zhu, Daniel J. DeAngelo, Andy Boral, Beni B. Wolf
Publikováno v:
Science Translational Medicine. 9
Targeting oncogenic kinase drivers with small-molecule inhibitors can have marked therapeutic benefit, especially when administered to an appropriate genomically defined patient population. Cancer genomics and mechanistic studies have revealed that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6e3ad5639cb0b7a03fc75164a59dec
https://doi.org/10.1126/scitranslmed.aao1690
https://doi.org/10.1126/scitranslmed.aao1690
Autor:
Erica K, Evans, Alexandra K, Gardino, Joseph L, Kim, Brian L, Hodous, Adam, Shutes, Alison, Davis, Xing Julia, Zhu, Oleg, Schmidt-Kittler, Doug, Wilson, Kevin, Wilson, Lucian, DiPietro, Yulian, Zhang, Natasja, Brooijmans, Timothy P, LaBranche, Agnieszka, Wozniak, Yemarshet K, Gebreyohannes, Patrick, Schöffski, Michael C, Heinrich, Daniel J, DeAngelo, Stephen, Miller, Beni, Wolf, Nancy, Kohl, Timothy, Guzi, Nicholas, Lydon, Andy, Boral, Christoph, Lengauer
Publikováno v:
Science translational medicine. 9(414)
Targeting oncogenic kinase drivers with small-molecule inhibitors can have marked therapeutic benefit, especially when administered to an appropriate genomically defined patient population. Cancer genomics and mechanistic studies have revealed that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44c23e872b4ee8effe4e9b9a2cdce3de
https://pubmed.ncbi.nlm.nih.gov/30023395
https://pubmed.ncbi.nlm.nih.gov/30023395
Autor:
Patricia McElroy, Beth Ziegler, Karina Romero, Mary K. Stanton, Stephanie D. Geuns-Meyer, Vinod F. Patel, Hanh Nho Nguyen, Tammy L. Bush, Victor J. Cee, Holly L. Deak, Patrick Eden, Robert Radinsky, Laurie B. Schenkel, Brian L. Hodous, Richard Kendall, Marc Payton, Isabelle Dussault, Philip R. Olivieri, Grace Tin-Yun Chung, Sandra Ross, Annette Bak
Publikováno v:
Cancer Research. 70:9846-9854
In mammalian cells, the aurora kinases (aurora-A, -B, and -C) play essential roles in regulating cell division. The expression of aurora-A and -B is elevated in a variety of human cancers and is associated with high proliferation rates and poor progn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98b94d01efc18809bf5178153e6e3ec
https://doi.org/10.1158/0008-5472.can-10-3001
https://doi.org/10.1158/0008-5472.can-10-3001
Autor:
Ji-Rong Sun, Steve Bellon, Paul Gallant, Michael Morrison, Richard Kendall, Holly L. Deak, Karina Romero, Robert Radinsky, Patrick Eden, Kelly Hanestad, Laurie B. Schenkel, Alan C. Cheng, Paul E. Rose, Huilin Zhao, Victor J. Cee, Marc Payton, Min-Hwa Jasmine Lin, Vinod F. Patel, Xuhai Be, Stephanie D. Geuns-Meyer, Tammy L. Bush, Hanh Nho Nguyen, Steve Coats, Philip R. Olivieri, Annette Bak, Xin Huang, Brian L. Hodous, Grace Tin-Yun Chung, Jin Tang, Yan Gu, Sandra Ross
Publikováno v:
Journal of Medicinal Chemistry. 53:6368-6377
The discovery of aurora kinases as essential regulators of cell division has led to intense interest in identifying small molecule aurora kinase inhibitors for the potential treatment of cancer. A high-throughput screening effort identified pyridinyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fe137f862d7b6d8e1cd934b1c4f7b4
https://doi.org/10.1021/jm100394y
https://doi.org/10.1021/jm100394y
Autor:
Alan C. Cheng, Karina Romero, Jasmine Lin, Hanh Nho Nguyen, Yihong Zhou, Paul E. Hughes, Vinod F. Patel, Stephanie D. Geuns-Meyer, Philip R. Olivieri, James Bready, Annette Bak, Sean Caenepeel, Joseph L. Kim, Holly L. Deak, Alexander M. Long, Angela Coxon, Steve Bellon, Douglas A. Whittington, Victor J. Cee, Brian L. Hodous, Yan Gu, Ling Wang, Jenne Fretland, Christopher Mohr, Xin Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:424-427
Selective small molecule inhibitors of Tie-2 kinase are important tools for the validation of Tie-2 signaling in pathological angiogenesis. Reported herein is the optimization of a nonselective scaffold into a potent and highly selective inhibitor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bda588e874cbf60bd04e1f234064502
https://doi.org/10.1016/j.bmcl.2008.11.056
https://doi.org/10.1016/j.bmcl.2008.11.056