Výsledky vyhledávání - "Brian L. Hillcoat"

A pharmacokinetic and phase II study of gallium nitrate in patients with non-small cell lung cancer

Autor: Lorraine K. Webster, Brian L. Hillcoat, Ian N. Olver, Robert G. Sephton, James F. Bishop, Kerrie H. Stokes

Publikováno v: Cancer Chemotherapy and Pharmacology. 45:55-58

This study investigated the pharmacokinetics and activity of gallium nitrate in non-small cell lung cancer when 700 mg/m2 was given as a 30-min infusion with prehydration every 2 weeks. Gallium was measured in plasma and urine using flameless atomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de516da11cdc094ca0f68bb2f0b076d
https://doi.org/10.1007/pl00006743

Zobrazit plný text záznamu

Issues and Concerns for the Registration of Biological Products in Australia

Autor: Brian L. Hillcoat

Publikováno v: Drug Information Journal. 31:1395-1400

The Australian Guidelines for the Registration of Drugs recommend the contents and format of applications to register biologicals in Australia. This follows European guidelines and the European Union (EU) format is preferred. Registration does not re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::917519b69d2cf85a6fccca1bd4ff717c
https://doi.org/10.1177/009286159703100445

Zobrazit plný text záznamu

cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity

Autor: Lorraine K. Webster, Brian L. Hillcoat, David P. Buxton, Alison M. James, Tracey L. Williams, Robin J. Thomson, Ian A. G. Roos, Glen B. Deacon, Laurence P. G. Wakelin

Publikováno v: Monash University

The platinum(II) organoamides [Pt(NRCH2)2L2] (L = pyridine (py), R = p-HC6F4, C6F5,p-IC6F4,p-CIC6F4,p-C6F5C6F4; L = 4-methylpyridine, R = p-HC6F4) and [Pt(NRCH2CH2NR')(py)2] (R = p-HC6F4, R' = C6F5, p-BrC6F4, or p-MeC6F4) inhibit the growth of murine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccce71515e1b9968c4623efa11d6a21
https://doi.org/10.1021/jm00096a007

Zobrazit plný text záznamu

Metallothionein-like proteins and cell resistance tocis-dichlorodiammineplatinum(II) in L1210 cells

Autor: Ian A. G. Roos, Brian L. Hillcoat, Paul G. Farnworth

Publikováno v: Cancer Chemotherapy and Pharmacology. 25:411-417

Our studies on the mechanism of resistance of the murine leukemia L1210-PDD line to cis-dichlorodiammineplatinum(II) (cis-DDP) have not shown why it is 10-fold more resistant to the drug than the L1210 line. For this reason we investigated metallothi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68b02ab25d7e367d0c11ee828e21398
https://doi.org/10.1007/bf00686051

Zobrazit plný text záznamu

Rectal adenocarcinoma with germ cell elements treated with chemotherapy

Autor: Danny Rischin, C Riley, Brian L. Hillcoat, Andrew G. Östör, Warren M. McNaughton, Denys W. Fortune

Publikováno v: Pathology. 25(3)

A patient with adenocarcinoma of the rectum containing germ cell elements in the form of endodermal sinus tumor and choriocarcinoma is described, believed to be the first such tumor reported in the literature. The serum levels of alpha-fetoprotein an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c6f0a7bc7310a5a4e8b13027d186a1
https://pubmed.ncbi.nlm.nih.gov/7505421

Zobrazit plný text záznamu

A phase I study of doxifluridine as a five-day stepped-dose continuous infusion

Autor: Brian L. Hillcoat, James F. Bishop, Theodore W. Guentert, Phillip A. Reece, Raymond G. Morris, Ian N. Olver

Publikováno v: American journal of clinical oncology. 13(4)

Doxifluridine (5'-dFUR) is a prodrug of 5 fluorouracil (5-FU) synthesized in an attempt to improve the therapeutic index compared with 5-FU. In this phase I study, cohorts of three patients were treated by a 5-day continuous infusion with the dose in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31701f78004c8e4fc8d204a55ad9cee4
https://pubmed.ncbi.nlm.nih.gov/2143051

Zobrazit plný text záznamu

Pharmacokinetic study of doxifluridine given by 5-day stepped-dose infusion

Autor: Raymond G. Morris, Thedore W. Guentert, Phillip A. Reece, Ian N. Olver, Heather S. Hill, Brian L. Hillcoat, James F. Bishop

Publikováno v: Cancer chemotherapy and pharmacology. 25(4)

Doxifluridine (5'-deoxy-5-fluorouridine, 5'-dFUR) metabolism has been reported to be saturable and associated with a fall in clearance of the drug as the dose is increased. The aim of the present study was to determine the disposition of 5'-dFUR and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a991b7b571d5b2d934b4a203e8bee34
https://pubmed.ncbi.nlm.nih.gov/2136810

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání