Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Brian L. Gilmore"'
Autor:
Deborah F. Kelly, Sarah M. McDonald, Madeline J. Dukes, Allison O. McKell, Crystal E. Boudreaux, Justin R. Tanner, Brian L. Gilmore
Publikováno v:
Micromachines, Vol 4, Iss 1, Pp 90-102 (2013)
Here we present new applications for silicon nitride (SiN) membranes to evaluate biological processes. We determined that 50-nanometer thin films of SiN produced from silicon wafers were sufficiently durable to bind active rotavirus assemblies. A dir
Externí odkaz:
https://doaj.org/article/7f610e3ee6c44ba9acd5dab259cfe963
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 1, Iss 1 (2012)
Cryo-Electron Microscopy (EM) is a powerful technique to visualize biological processes at nanometer resolution. Structural studies of macromolecular assemblies are typically performed on individual complexes that are biochemically isolated from thei
Externí odkaz:
https://doaj.org/article/c7bb491619514be59f2688defdaca58e
Autor:
Yanping Liang, Nick A. Alden, Maria J. Solares, William J. Dearnaley, A. Cameron Varano, Zhi Sheng, Elizabeth Alli, Deborah F. Kelly, Brian L. Gilmore, Kevin J. Pridham
Publikováno v:
DNA Repair. 73:120-128
Given its important role in human health and disease, remarkably little is known about the full-length three-dimensional (3D) molecular architecture of the breast cancer type 1 susceptibility protein (BRCA1), or its mechanisms to engage the tumor sup
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 1, Iss 1, p e201204003 (2012)
Cryo-Electron Microscopy (EM) is a powerful technique to visualize biological processes at nanometer resolution. Structural studies of macromolecular assemblies are typically performed on individual complexes that are biochemically isolated from thei
Externí odkaz:
https://doaj.org/article/f31c7b4e05ef439bb6b3143ba51dc865
Autor:
Carly E. Winton, Zhi Sheng, Justin R. Tanner, Deborah F. Kelly, Brian L. Gilmore, A. Cameron Varano
Publikováno v:
Microscopy Today. 25:22-27
Recent breakthroughs in cryo-electron microscopy imaging technology provide an unprecedented view of biology at the nanoscale. To complement these technical advances, here we demonstrate the use of tunable substrates to streamline the isolation of bi
Autor:
Deborah F. Kelly, Bridget C. Marcinkowski, Yanping Liang, Brian L. Gilmore, William J. Dearnaley, Madeline J. Dukes, A. Cameron Varano
Publikováno v:
Protein Complex Assembly ISBN: 9781493977581
Recent advances in technology have enabled single-particle electron microscopy (EM) to rapidly progress as a preferred tool to study protein assemblies. Newly developed materials and methods present viable alternatives to traditional EM specimen prep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2834415a7cb4108c4d9fc020a30c4570
https://doi.org/10.1007/978-1-4939-7759-8_3
https://doi.org/10.1007/978-1-4939-7759-8_3
Autor:
Carly E. Winton, William J. Dearnaley, Nick A. Alden, Yanping Liang, Brian L. Gilmore, Zhi Sheng, A. Cameron Varano, Deborah F. Kelly
Publikováno v:
Science Advances
Cracking the BRCA-BARD code—structural biology reveals the face of BRCA1.
Cancer cells afflicted with mutations in the breast cancer susceptibility protein (BRCA1) often suffer from increased DNA damage and genomic instability. The precise man
Cancer cells afflicted with mutations in the breast cancer susceptibility protein (BRCA1) often suffer from increased DNA damage and genomic instability. The precise man
Autor:
Kaya Patel, Zhi Sheng, Deborah F. Kelly, Brian L. Gilmore, Carly E. Winton, Vasilea Karageorge, Yanping Liang, A. Cameron Varano, Wwilliam Dearnaley
Publikováno v:
Scientific Reports
The precise manner in which physical changes to the breast cancer susceptibility protein (BRCA1) affect its role in DNA repair events remain unclear. Indeed, cancer cells harboring mutations in BRCA1 suffer from genomic instability and increased DNA
Autor:
Sarah M. McDonald, Donald C. Vile, Crystal E. Boudreaux, Deborah F. Kelly, Brian L. Gilmore, Justin R. Tanner
Publikováno v:
Journal of General Virology. 94:1818-1826
The triple-layered rotavirus virion encases an 11-segmented, dsRNA genome and 11–12 copies of the viral polymerase (VP1). VP1 transcribes and replicates the genome while tethered beneath the VP2 core shell. Genome replication (i.e. minus-strand RNA
Autor:
Andrew C. Demmert, Carly E. Winton, Zhi Sheng, Deborah F. Kelly, Vasilea Karageorge, Brian L. Gilmore
Publikováno v:
NPJ Breast Cancer
Recent advances in the development of functional materials offer new tools to dissect human health and disease mechanisms. The use of tunable surfaces is especially appealing as substrates can be tailored to fit applications involving specific cell t