Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Brian L. Batley"'
Autor:
Brian G. Hartl, Randy Steinkampf, T C Major, Joan A. Keiser, Tawny K. Dahring, H. D. Hollis Showalter, Gina H. Lu, Alan J. Kraker, Robert L. Panek, Hussein Hallak, Brian L. Batley, Zhipei Wu, Bill J. Roberts, Sylvester Klutchko, Sandra J. Patmore, William L. Elliott, Laura A. Bradford, Wayne D. Klohs, Annette Marian Doherty, James Marino Hamby, Diane H. Boschelli
Publikováno v:
Journal of Medicinal Chemistry. 41:4365-4377
Screening of a compound library led to the identification of 2-amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidine (1) as a inhibitor of the platelet-derived growth factor receptor (PDGFr), fibroblast growth factor receptor (FGFr), and c-src
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc761f1e47ac7d9db7f59488360a5bd4
https://doi.org/10.1021/jm980398y
https://doi.org/10.1021/jm980398y
Autor:
Kunchur Guruprasad, Chetana Rao-Naik, Brian L. Batley, Ben M. Dunn, Tom L. Blundell, John Kay, Jeffrey Hill, Stephen T. Rapundalo
Publikováno v:
Proteins: Structure, Function, and Genetics. 22:168-181
Aspartic proteinases are produced in the human body by a variety of cells. Some of these proteins, examples of which are pepsin, gastricsin, and renin, are secreted and exert their effects in the extracellular spaces. Cathepsin D and cathepsin E on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72ff98a8f5330c96538160b249f772f
https://doi.org/10.1002/prot.340220209
https://doi.org/10.1002/prot.340220209
Autor:
Brian L. Batley, R. K. Palmer, Stephen T. Rapundalo, David G. Taylor, Michael J. Ryan, A. E. Barnes, Snigdha Singh
Publikováno v:
Clinical and Experimental Hypertension. 15:663-681
A dissociation between changes in blood pressure (BP) and plasma renin activity (PRA) has been noted after administration of renin inhibitors. In the present study, the renin inhibitor PD 132002 was given to salt-deplete, anesthetized dogs. PRA was m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715282227bb2277c56df6770f3e60f14
https://doi.org/10.3109/10641969309041636
https://doi.org/10.3109/10641969309041636
Autor:
D. G. Jun. Taylor, M. D. Taylor, C. A. Painchaud, Brian L. Batley, Michael J. Ryan, Stephen T. Rapundalo, Connolly Cleo, Harriet W. Hamilton, William C. Patt
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60a521e11156b7cb196101eade1ad6e3
https://doi.org/10.1002/chin.199234276
https://doi.org/10.1002/chin.199234276
Autor:
Gary P. Hingorani, B. A. Steinbaugh, Christine Humblet, M. D. Taylor, Tomi K. Sawyer, James Stanley Kaltenbronn, Aurash Shahripour, Mark Stephen Plummer, James Marino Hamby, Elizabeth A. Lunney, Stephen T. Rapundalo, Annette Marian Doherty, Harriet W. Hamilton, Brian L. Batley
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d23c230e13ec4f213a0cd76b5d6a293c
https://doi.org/10.1002/chin.199547243
https://doi.org/10.1002/chin.199547243
Autor:
Alan J. Kraker, William L. Elliott, Sheila M. Crean, Tawny K. Dahring, Charles W. Moore, Patrick J. Grohar, Cleo J. C. Connolly, Mark R. Barvian, Gina Lu, H. D. Hollis Showalter, Patrick Vincent, Terry C. Major, and Annette M. Doherty, Robert L. Panek, Denise L. Driscoll, James M. Hamby, Mel C. Schroeder, Stacey L. Boushelle, Brian L. Batley, R. Thomas Winters
Publikováno v:
Journal of medicinal chemistry. 44(12)
In continuing our search for medicinal agents to treat proliferative diseases, we have discovered 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas as a novel class of soluble, potent, broadly active tyrosine kinase (TK) inhibitors. An efficient r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404cfa4f92f436aa35b392e52070e9a2
https://pubmed.ncbi.nlm.nih.gov/11384237
https://pubmed.ncbi.nlm.nih.gov/11384237
Autor:
William A. Denny, Robert L. Panek, Brian L. Batley, Andrew M. Thompson, Stacey L. Boushelle, Gina H. Lu, H. D. Hollis Showalter, Gordon W. Rewcastle, Brian G. Hartl, Alan J. Kraker
Publikováno v:
Journal of medicinal chemistry. 43(16)
7-substituted 3-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones are potent inhibitors of protein tyrosine kinases, with some selectivity for c-Src. The compounds were prepared by condensing 4, 6-diaminonicotinaldehyde with 2,6-dichlorophenylacetonit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbf98d01a162b8164e45598fd724727
https://pubmed.ncbi.nlm.nih.gov/10956222
https://pubmed.ncbi.nlm.nih.gov/10956222
Autor:
Alan J. Kraker, William A. Denny, Brian D. Palmer, Robert L. Panek, Brian G. Hartl, Gina H. Lu, H. D. Hollis Showalter, Susanne Trumpp-Kallmeyer, Athanasia D. Panopoulos, Brian L. Batley
Publikováno v:
Journal of medicinal chemistry. 42(13)
Following an earlier discovery of 1-phenylbenzimidazoles as ATP-site inhibitors of the platelet-derived growth factor receptor (PDGFR), further structure-activity relationships for analogues (particularly 5-substituted derivatives) are reported. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff02ae32c84e2f6c614152ed6cc7f36a
https://pubmed.ncbi.nlm.nih.gov/10395478
https://pubmed.ncbi.nlm.nih.gov/10395478
Autor:
Stephen T. Rapundalo, C. Humblet, G. Hingorani, Brian L. Batley, J. Hamby, M. Plummer, E. Lunney
Publikováno v:
Peptides ISBN: 9789401042956
Peptides
Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b56270e392917597ea2a68de25508b26
https://doi.org/10.1007/978-94-011-0683-2_209
https://doi.org/10.1007/978-94-011-0683-2_209
Autor:
Brian L. Batley, Chetana M. Rao, Sylvester Klutchko, Elizabeth A. Lunney, Michael Taylor, Christine Humblet, Paula E. Scarborough, Stephen T. Rapundalo, John Kay, Ben M. Dunn
Publikováno v:
Journal of medicinal chemistry. 36(18)
To understand the differences in the binding specificities within the aspartic proteinase family of enzymes, we have carried out studies to determine the inhibition constants of a set of related compounds with various members of the human enzyme fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1e3ce8d706de3cd579415562e1ee86
https://pubmed.ncbi.nlm.nih.gov/8410973
https://pubmed.ncbi.nlm.nih.gov/8410973