Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Brian L Mark"'
Autor:
Mariska van Huizen, Jonna R Bloeme-Ter Horst, Heidi L M de Gruyter, Paul P Geurink, Gerbrand J van der Heden van Noort, Robert C M Knaap, Tessa Nelemans, Natacha S Ogando, Anouk A Leijs, Nadya Urakova, Brian L Mark, Eric J Snijder, Sebenzile K Myeni, Marjolein Kikkert
Publikováno v:
PLoS Pathogens, Vol 20, Iss 3, p e1012100 (2024)
The coronavirus papain-like protease (PLpro) is crucial for viral replicase polyprotein processing. Additionally, PLpro can subvert host defense mechanisms by its deubiquitinating (DUB) and deISGylating activities. To elucidate the role of these acti
Externí odkaz:
https://doaj.org/article/7f36d353de494643ab5436ca01691fdd
Autor:
Ben A Bailey-Elkin, Robert C M Knaap, Anuradha De Silva, Ilse M Boekhoud, Sandra Mous, Niek van Vught, Mazdak Khajehpour, Erwin van den Born, Marjolein Kikkert, Brian L Mark
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011872 (2023)
Deubiquitination of cellular substrates by viral proteases is a mechanism used to interfere with host cellular signaling processes, shared between members of the coronavirus- and arterivirus families. In the case of Arteriviruses, deubiquitinating an
Externí odkaz:
https://doaj.org/article/295d5f2bdd0640f59f8fca11b2652ab5
Autor:
Vera J E van Vliet, Nhan Huynh, Judith Palà, Ankoor Patel, Alex Singer, Cole Slater, Jacky Chung, Mariska van Huizen, Joan Teyra, Shane Miersch, Gia-Khanh Luu, Wei Ye, Nitin Sharma, Safder S Ganaie, Raquel Russell, Chao Chen, Mindy Maynard, Gaya K Amarasinghe, Brian L Mark, Marjolein Kikkert, Sachdev S Sidhu
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1011065 (2022)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating coronavirus outbreaks benefits from a combination of vaccines and therapeutics. A promising drug target common to all coronaviruses-including S
Externí odkaz:
https://doaj.org/article/ed5803623a7743ac82f5abe2f5dcf89b
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008283 (2020)
BACKGROUND:The Crimean-Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health Organization (WHO) has listed CCHFVas a priority pathogen with an urgent need for enhanced rese
Externí odkaz:
https://doaj.org/article/59d032dbc526464a897039adead39963
Autor:
Wei Zhang, Ben A Bailey-Elkin, Robert C M Knaap, Baldeep Khare, Tim J Dalebout, Garrett G Johnson, Puck B van Kasteren, Nigel J McLeish, Jun Gu, Wenguang He, Marjolein Kikkert, Brian L Mark, Sachdev S Sidhu
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006372 (2017)
The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective therapeutic countermeasures. Ma
Externí odkaz:
https://doaj.org/article/824053ad4d4a40009c0e1572fe623231
Autor:
Michael B Tropak, Sayuri Yonekawa, Subha Karumuthil-Melethil, Patrick Thompson, Warren Wakarchuk, Steven J Gray, Jagdeep S Walia, Brian L Mark, Don Mahuran
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Tay-Sachs or Sandhoff disease result from mutations in either the evolutionarily related HEXA or HEXB genes encoding respectively, the α- or β-subunits of β-hexosaminidase A (HexA). Of the three Hex isozymes, only HexA can interact with its cofact
Externí odkaz:
https://doaj.org/article/6de70c93a5c54cd896357242c801a7ab
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149204 (2016)
FlgJ is a glycoside hydrolase (GH) enzyme belonging to the Carbohydrate Active enZyme (CAZy) family GH73. It facilitates passage of the bacterial flagellum through the peptidoglycan (PG) layer by cleaving the β-1,4 glycosidic bond between N-acetylgl
Externí odkaz:
https://doaj.org/article/d7918ff255c04516afc0e46a6138655c
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1003894 (2014)
Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the Ovarian Tumor (OTU) superfamily of deubiquitinases (DUBs). The publication of the latest of these reports in qu
Externí odkaz:
https://doaj.org/article/473d434cc64f46dfa5886c6f578b807c
Autor:
Incilay Sinici, Sayuri Yonekawa, Ilona Tkachyova, Steven J Gray, R Jude Samulski, Warren Wakarchuk, Brian L Mark, Don J Mahuran
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57908 (2013)
The hydrolysis in lysosomes of GM2 ganglioside to GM3 ganglioside requires the correct synthesis, intracellular assembly and transport of three separate gene products; i.e., the alpha and beta subunits of heterodimeric beta-hexosaminidase A, E.C. # 3
Externí odkaz:
https://doaj.org/article/4df25f80c5ab47469e0a8236857830c9
Together with the fundamentals of probability, random processes and statistical analysis, this insightful book also presents a broad range of advanced topics and applications. There is extensive coverage of Bayesian vs. frequentist statistics, time s
