Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.

Autor: Megan M Sperry, Tomiko T Oskotsky, Ivana Marić, Shruti Kaushal, Takako Takeda, Viktor Horvath, Rani K Powers, Melissa Rodas, Brooke Furlong, Mercy Soong, Pranav Prabhala, Girija Goyal, Kenneth E Carlson, Ronald J Wong, Idit Kosti, Brian L Le, James Logue, Holly Hammond, Matthew Frieman, David K Stevenson, Donald E Ingber, Marina Sirota, Richard Novak

Publikováno v: PLoS Computational Biology, Vol 19, Iss 5, p e1011050 (2023)

Drug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In response to the chall

Externí odkaz: https://doaj.org/article/cfab81f7026e481d8f6ae5a6eade32cd

Data-driven longitudinal characterization of neonatal health and morbidity

Autor: Davide De Francesco, Jonathan D. Reiss, Jacquelyn Roger, Alice S. Tang, Alan L. Chang, Martin Becker, Thanaphong Phongpreecha, Camilo Espinosa, Susanna Morin, Eloïse Berson, Melan Thuraiappah, Brian L. Le, Neal G. Ravindra, Seyedeh Neelufar Payrovnaziri, Samson Mataraso, Yeasul Kim, Lei Xue, Melissa G. Rosenstein, Tomiko Oskotsky, Ivana Marić, Brice Gaudilliere, Brendan Carvalho, Brian T. Bateman, Martin S. Angst, Lawrence S. Prince, Yair J. Blumenfeld, William E. Benitz, Janene H. Fuerch, Gary M. Shaw, Karl G. Sylvester, David K. Stevenson, Marina Sirota, Nima Aghaeepour

Publikováno v: Science Translational Medicine. 15

Although prematurity is the single largest cause of death in children under 5 years of age, the current definition of prematurity, based on gestational age, lacks the precision needed for guiding care decisions. Here, we propose a longitudinal risk a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::594e3efa690872915f64e0dbc15b7758
https://doi.org/10.1126/scitranslmed.adc9854

Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients

Autor: Megan M. Sperry, Tomiko Oskotsky, Ivana Marić, Shruti Kaushal, Takako Takeda, Viktor Horvath, Rani K. Powers, Melissa Rodas, Brooke Furlong, Mercy Soong, Pranav Prabhala, Girija Goyal, Kenneth E. Carlson, Ronald J. Wong, Idit Kosti, Brian L. Le, James Logue, Holly Hammond, Matthew Frieman, David K. Stevenson, Donald E. Ingber, Marina Sirota, Richard Novak

Publikováno v: medRxiv
PLoS computational biology, vol 19, iss 5

SummaryImportanceDrug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30e7c259c82c34fff7c6971e0274968
https://pubmed.ncbi.nlm.nih.gov/35441166

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19

Autor: Marina Sirota, Kris M. White, Romel Rosales, Brian L. Le, Gaia Andreoletti, Katharine Yu, Albert Vallejo-Gracia, Christine Li, G. Renuka Kumar, Adolfo García-Sastre, Daniel G. Bunis, Idit Kosti, Melanie Ott, Tomiko Oskotsky, Kristoffer E Leon

Publikováno v: Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Research Square
article-version (status) pre
article-version (number) 1

The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We utilized three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07339d7d9ccfa7485c892a597a75566
https://escholarship.org/uc/item/44s17770

A Digital Health Initiative (COVIDsmart) for Remote Data Collection and Study of COVID-19’s Impact on the State of Virginia: Prospective Cohort Study

Autor: Josh Schilling, Dave Klein, Marilyn M Bartholmae, Sepideh Shokouhi, Angela J Toepp, Amira A Roess, Joshua M Sill, Matvey V Karpov, Kathleen Maney, K Pearson Brown, Brian L Levy, Keith D Renshaw, Sunita Dodani, Praduman Jain

Publikováno v: JMIR Formative Research, Vol 7, p e37550 (2023)

BackgroundThe COVID-19 pandemic has affected people's lives beyond severe and long-term physical health symptoms. Social distancing and quarantine have led to adverse mental health outcomes. COVID-19–induced economic setbacks have also likely exace

Externí odkaz: https://doaj.org/article/286b5d98cdf34c199e1a500c2bc690f1