Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Brian L Kotzin"'
Autor:
Christie Fanton, Richard Furie, Vishala Chindalore, Robert Levin, Isam Diab, Neha Dixit, Cat Haglund, Jacqueline Gibbons, Nathan Hanan, Daniel Dickerson, Jonathan Zalevsky, Brian L. Kotzin
Publikováno v:
Journal of Translational Autoimmunity, Vol 5, Iss , Pp 100152- (2022)
Objective: To evaluate NKTR-358, a polyethylene glycol-interleukin-2 conjugate composition designed to selectively induce regulatory T cells (Tregs), in first-in-human studies. Methods: Healthy volunteers and patients with systemic lupus erythematosu
Externí odkaz:
https://doaj.org/article/49ce53a3c789438296c8f118762a593a
Autor:
Troy E. Metzger, Chao Jiang, Stephanie Atencio, Christina M. Mailloux, Hilda L. Enriquez, Loren D. Erickson, María Rosa Bono, Trine N. Jørgensen, William M. Loo, Jennifer Alfaro, Mario Rosemblatt, Brian L. Kotzin, Shannon Flannery, Stephen J. Rozzo, Melanie R. Gubbels Bupp
Publikováno v:
JOURNAL OF IMMUNOLOGY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune tolerance that leads to ant
Autor:
Trine N. Jørgensen, Naoki Morito, Liliane Fossati-Jimack, Lucie Clementine Baudino, Leonard H. Evans, Bernard J Morley, Shuichi Kikuchi, Timothy J. Vyse, Kumiko Yoshinobu, Sachiko Hirose, Brian L. Kotzin, Christina L. Roark, Rebecca M. Tucker, Shozo Izui
Publikováno v:
Journal of Immunology, Vol. 181, No 4 (2008) pp. 2846-54
The endogenous retroviral envelope glycoprotein, gp70, implicated in murine lupus nephritis is secreted by hepatocytes as an acute phase protein, and it has been thought to be a product of an endogenous xenotropic virus, NZB-X1. However, since endoge
Publikováno v:
Genes & Immunity. 9:47-56
Ninety percent of systemic lupus erythematosus patients are female, and gender differences in lupus susceptibility are also observed in (New Zealand Black x New Zealand White)F1 (BWF1) lupus-prone mice. We followed orchiectomized, intact male and fem
Autor:
Masaaki Murakami, Akemi Sakamoto, Khie Khiong, Toshio Hirano, John W. Kappler, Marileila Verella-Garcia, Naoko Ueda, Shinichiro Sawa, Philippa Marrack, Chika Kitabayashi, Katsuhiko Ishihara, Stephen J. Rozzo, Brian L. Kotzin
Publikováno v:
Journal of Clinical Investigation. 117:1270-1281
Patients with Omenn syndrome (OS) have hypomorphic RAG mutations and develop varying manifestations of severe combined immunodeficiency. It is not known which symptoms are caused directly by the RAG mutations and which depend on other polymorphic gen
Autor:
Alan Menter, Joanne Li, Alexa B. Kimball, Darryl Toth, April W. Armstrong, Wenjie Song, Gary Aras, Cassandra E Milmont, Lluís Puig, Brian L Kotzin, Jolanta Weglowska, Hervé Bachelez, John Koo, Ajay Nirula, Jean-Philippe Lacour, Leon H Kircik, Kristina Callis Duffin, Lynda Spelman, Francisco A. Kerdel, Mark Lebwohl, Tomasz Blicharski, Richard G. Langley, Bruce Strober, Stephen K. Tyring, Kim A. Papp, Jeffrey J. Crowley, Jashin J. Wu, Sergio Chimenti, Carle Paul, Kenneth B. Gordon, Yifei Shi, Paul Klekotka, Ngozi Erondu, Georg Stingl, Jerry Bagel
Publikováno v:
NEW ENGLAND JOURNAL OF MEDICINE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Early clinical studies suggested that the anti-interleukin-17 receptor A monoclonal antibody brodalumab has efficacy in the treatment of psoriasis.In two phase 3 studies (AMAGINE-2 and AMAGINE-3), patients with moderate-to-severe psoriasis were rando
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47ddc2f5ccc53f4bb1b06d5b762e857
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8339
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8339
Autor:
Brian M. Freed, Douglas G. Mack, Jerome Bill, Andrew P. Fontenot, Allison K. Martin, Brian L. Kotzin, Fenneke G. Joslin, Michael T. Falta, Lisa A. Maier, Andrew K. Sullivan
Publikováno v:
The Journal of Immunology. 175:7029-7037
Chronic beryllium disease (CBD) is characterized by a CD4+ T cell alveolitis and granulomatous inflammation in the lung. Genetic susceptibility to this disease has been linked with HLA-DP alleles, particularly those possessing a glutamic acid at posi
Autor:
Andrew P. Fontenot, Brent E. Palmer, Lee S. Newman, Cara C. Wilson, Lisa A. Maier, Fenneke G. Joslin, Andrew K. Sullivan, Brian L. Kotzin
Publikováno v:
Journal of Clinical Investigation. 115:2886-2893
Beryllium exposure can lead to the development of beryllium-specific CD4+ T cells and chronic beryllium disease (CBD), which is characterized by the presence of lung granulomas and a CD4+ T cell alveolitis. Studies have documented the presence of pro
Autor:
Norbert F. Voelkel, Kevin K. Brown, John D. Mitchell, Philip L. Simonian, Andrew P. Fontenot, Gregory P. Cosgrove, Michael T. Falta, Brian L. Kotzin, Andrew K. Sullivan
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:590-596
Rationale: Within the lungs of patients with severe emphysema, inflammation continues despite smoking cessation. Foci of T lymphocytes in the small airways of patients with emphysema have been associated with disease severity. Whether these T cells p
Autor:
Robert L. Fairchild, Xiaoxia Li, E. Charles Snow, Sidne A. Omori, Youcun Qian, Brian L. Kotzin, Carl F. Ware, Robert C. Rickert, Martin L. Scott, Grace Cui, Mayumi Naramura, Jinzhong Qin
Publikováno v:
Immunity. 21:575-587
TNF receptor (TNFR) superfamily members, CD40, and BAFFR play critical roles in B cell survival and differentiation. Genetic deficiency in a novel adaptor molecule, Act1, for CD40 and BAFF results in a dramatic increase in peripheral B cells, which c