A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells

Autor: Brian L Hua, Florine EM Scholte, Valerie Ohlendorf, Anne Kopp, Marco Marklewitz, Christian Drosten, Stuart T Nichol, Christina Spiropoulou, Sandra Junglen, Éric Bergeron

Publikováno v: eLife, Vol 9 (2020)

Crimean-Congo hemorrhagic fever (CCHF) is the most widely distributed tick-borne viral infection in the world. Strikingly, reported mortality rates for CCHF are extremely variable, ranging from 5% to 80% (Whitehouse, 2004). CCHF virus (CCHFV, Nairovi

Externí odkaz: https://doaj.org/article/272cbf6709bc4baf8f454ca96039430a

DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression

Autor: Terry L. Orr-Weaver, Brian L Hua

Publikováno v: Genetics. 207:29-47

Proper control of DNA replication is critical to ensure genomic integrity during cell proliferation. In addition, differential regulation of the DNA replication program during development can change gene copy number to influence cell size and gene ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::291436096431d3bd0849a6c9c01cd707
https://doi.org/10.1534/genetics.115.186627

Inhibition of Escherichia coli CTP Synthetase by NADH and Other Nicotinamides and Their Mutual Interactions with CTP and GTP

Autor: Roger Jesinghaus, Bita Shahrvini, Brian L Hua, Jason D. Lee, Justin M. Kollman, Enoch P. Baldwin, Rachael M. Barry, Zemer Gitai, Adithi Chandrasekhara, Chris H. Habrian

Publikováno v: Habrian, C; Chandrasekhara, A; Shahrvini, B; Hua, B; Lee, J; Jesinghaus, R; et al.(2016). Inhibition of Escherichia coli CTP Synthetase by NADH and Other Nicotinamides and Their Mutual Interactions with CTP and GTP. Biochemistry, 55(39), 5554-5565. doi: 10.1021/acs.biochem.6b00383. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/97c2m962
Biochemistry, vol 55, iss 39

© 2016 American Chemical Society. CTP synthetases catalyze the last step of pyrimidine biosynthesis and provide the sole de novo source of cytosine-containing nucleotides. As a central regulatory hub, they are regulated by ribonucleotide and enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c211aa02ca3669b67787bb383d0decc8
http://www.escholarship.org/uc/item/97c2m962

The Role of Transcription in the Activation of a Drosophila Amplification Origin

Autor: Terry L. Orr-Weaver, Sharon Li, Brian L Hua

Publikováno v: G3
G3: Genes|Genomes|Genetics

The mechanisms that underlie metazoan DNA replication initiation, especially the connection between transcription and replication origin activation, are not well understood. To probe the role of transcription in origin activation, we exploited a spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3fab885beb66c7a581b78581ce9f8c
http://hdl.handle.net/1721.1/96690

Skin Manifestations of Inflammatory Bowel Disease

Autor: Brian L Huang, Stephanie eChandra, David Quan Shih

Publikováno v: Frontiers in Physiology, Vol 3 (2012)

Inflammatory bowel disease (IBD) is a disease that affects the intestinal tract via an inflammatory process. Patients who suffer from IBD often have diseases that affect multiple other organ systems as well. These are called extraintestinal manifesta

Externí odkaz: https://doaj.org/article/3f22676e6312404f9df8faf31fc3de27