Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Brian L Hill"'
Autor:
David Goodman-Meza, Akos Rudas, Jeffrey N Chiang, Paul C Adamson, Joseph Ebinger, Nancy Sun, Patrick Botting, Jennifer A Fulcher, Faysal G Saab, Rachel Brook, Eleazar Eskin, Ulzee An, Misagh Kordi, Brandon Jew, Brunilda Balliu, Zeyuan Chen, Brian L Hill, Elior Rahmani, Eran Halperin, Vladimir Manuel
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239474 (2020)
Worldwide, testing capacity for SARS-CoV-2 is limited and bottlenecks in the scale up of polymerase chain reaction (PCR-based testing exist. Our aim was to develop and evaluate a machine learning algorithm to diagnose COVID-19 in the inpatient settin
Externí odkaz:
https://doaj.org/article/3eec3b81f1c34773982085daf77adb3e
Autor:
Mike Thompson, Brian L. Hill, Nadav Rakocz, Jeffrey N. Chiang, Daniel Geschwind, Sriram Sankararaman, Ira Hofer, Maxime Cannesson, Noah Zaitlen, Eran Halperin
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Inference of clinical phenotypes is a fundamental task in precision medicine, and has therefore been heavily investigated in recent years in the context of electronic health records (EHR) using a large arsenal of machine learning techniques,
Externí odkaz:
https://doaj.org/article/efe675b8dfee482c92c645bd51ac0f81
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The validity of Mendelian Randomization (MR) studies may be affected by population stratification, batch effects, and horizontal pleiotropy. Here, the authors develop MR-SENSEMAKR, allowing quantification of the robustness of MR findings.
Externí odkaz:
https://doaj.org/article/6edca1795c2a4ce4a85765b66759992d
Autor:
Brian L. Hill, Nadav Rakocz, Ákos Rudas, Jeffrey N. Chiang, Sidong Wang, Ira Hofer, Maxime Cannesson, Eran Halperin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract In two-thirds of intensive care unit (ICU) patients and 90% of surgical patients, arterial blood pressure (ABP) is monitored non-invasively but intermittently using a blood pressure cuff. Since even a few minutes of hypotension increases the
Externí odkaz:
https://doaj.org/article/80a96a20abd34c43a3f0742ea23f08d7
Autor:
Nadav Rakocz, Jeffrey N. Chiang, Muneeswar G. Nittala, Giulia Corradetti, Liran Tiosano, Swetha Velaga, Michael Thompson, Brian L. Hill, Sriram Sankararaman, Jonathan L. Haines, Margaret A. Pericak-Vance, Dwight Stambolian, Srinivas R. Sadda, Eran Halperin
Publikováno v:
npj Digital Medicine, Vol 4, Iss 1, Pp 1-13 (2021)
Abstract One of the core challenges in applying machine learning and artificial intelligence to medicine is the limited availability of annotated medical data. Unlike in other applications of machine learning, where an abundance of labeled data is av
Externí odkaz:
https://doaj.org/article/db547242a9544aa0933b586e70820352
Autor:
Mingzhou Fu, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working Group, Timothy S. Chang, Anna L. Antonio, Maryam Ariannejad, Angela M. Badillo, Brunilda Balliu, Yael Berkovich, Michael Broudy, Tony Dang, Chris Denny, Eleazar Eskin, Eran Halperin, Brian L. Hill, Ankur Jain, Vivek Katakwar, Clara Lajonchere, Clara Magyar, Sheila Minton, Ghouse Mohammed, Ariff Muhamed, Pabba Pavan, Michael A. Pfeffer, Nadav Rakocz, Akos Rudas, Rey Salonga, Timothy J. Sanders, Paul Tung, Vu Vu, Ailsa Zheng, Ruth Jhnson, Yi Ding, Alec Chiu, Jae-Hoon Sul, Sriram Sankraraman, Bogdan Pasaniuc
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s disease (AD) is the most common form of dementia and a growing public health burden in the United States. Significant progress has been made in identifying genetic risk for AD, but limited studies have investigated how AD genetic risk m
Externí odkaz:
https://doaj.org/article/d7c346ab263a4b27a45f08b832a88996
Autor:
Keith Mitchell, Jaqueline J. Brito, Igor Mandric, Qiaozhen Wu, Sergey Knyazev, Sei Chang, Lana S. Martin, Aaron Karlsberg, Ekaterina Gerasimov, Russell Littman, Brian L. Hill, Nicholas C. Wu, Harry Taegyun Yang, Kevin Hsieh, Linus Chen, Eli Littman, Taylor Shabani, German Enik, Douglas Yao, Ren Sun, Jan Schroeder, Eleazar Eskin, Alex Zelikovsky, Pavel Skums, Mihai Pop, Serghei Mangul
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Recent advancements in next-generation sequencing have rapidly improved our ability to study genomic material at an unprecedented scale. Despite substantial improvements in sequencing technologies, errors present in the data still
Externí odkaz:
https://doaj.org/article/4e1a4233b84144cea72cc63ae67e98ba
Autor:
Serghei Mangul, Lana S. Martin, Brian L. Hill, Angela Ka-Mei Lam, Margaret G. Distler, Alex Zelikovsky, Eleazar Eskin, Jonathan Flint
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Benchmarking studies are important for comprehensively understanding and evaluating different computational omics methods. Here, the authors review practices from 25 recent studies and propose principles to improve the quality of benchmarking studies
Externí odkaz:
https://doaj.org/article/a3c0bd0bb13543f8b62f96c08042e5be
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101185- (2020)
Summary: Single-cell RNA-sequencing (scRNA-seq) is a set of technologies used to profile gene expression at the level of individual cells. Although the throughput of scRNA-seq experiments is steadily growing in terms of the number of cells, large dat
Externí odkaz:
https://doaj.org/article/2909a4f5b59d4a5cb7c42672dd077ee0
Autor:
Danielle Klinger, Brian L. Hill, Noam Barda, Eran Halperin, Ofer N. Gofrit, Charles L. Greenblatt, Nadav Rappoport, Michal Linial, Hervé Bercovier
Publikováno v:
Vaccines, Vol 9, Iss 5, p 491 (2021)
Bacillus Calmette–Guerin (BCG) is a live attenuated form of Mycobacterium bovis that was developed 100 years ago as a vaccine against tuberculosis (TB) and has been used ever since to vaccinate children globally. It has also been used as the first-
Externí odkaz:
https://doaj.org/article/440da4870ede4825aba614f24fe8735d