Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Brian L, Calver"'
Autor:
Angelos Thanassoulas, Vyronia Vassilakopoulou, Brian L. Calver, Luke Buntwal, Adrian Smith, Christopher Lai, Iris Kontogianni, Evangelia Livaniou, George Nounesis, F. Anthony Lai, Michail Nomikos
Calmodulin (CaM) modulates the activity of several proteins that play a key role in excitation-contraction coupling (ECC). In cardiac muscle, the major binding partner of CaM is the type-2 ryanodine receptor (RyR2) and altered CaM binding contributes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889d38776f738738aa2a1e3030e2d0c2
https://www.sciencedirect.com/science/article/pii/S0304416523000119
https://www.sciencedirect.com/science/article/pii/S0304416523000119
Autor:
Yan Tong, Silpa Gampala, Ellie Rad, Ren Yuan Bai, Olivia Babb, Emily Hulsey, Fenil Shah, Chi Zhang, Steven D. Rhodes, Verena Staedtke, Randall Wireman, Brian L. Calver, Mark R. Kelley, Michelle Grimard, M. Reza Saadatzadeh, Abbi Smith, D. Wade Clapp, Andrew R. Tee, Karen E. Pollok, Melissa L. Fishel
Publikováno v:
British Journal of Cancer
Background MPNST is a rare soft-tissue sarcoma that can arise from patients with NF1. Existing chemotherapeutic and targeted agents have been unsuccessful in MPNST treatment, and recent findings implicate STAT3 and HIF1-α in driving MPNST. The DNA-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec69838060868f6ccae17ccdf078f1f2
http://europepmc.org/articles/PMC8076291
http://europepmc.org/articles/PMC8076291
Autor:
Jesse D. Champion, Kayleigh M. Dodd, Hilaire C. Lam, Mohammad A. M. Alzahrani, Sara Seifan, Ellie Rad, David Oliver Scourfield, Melissa L. Fishel, Brian L. Calver, Ann Ager, Elizabeth P. Henske, David Mark Davies, Mark R. Kelley, Andrew R. Tee
Publikováno v:
Cancers; Volume 14; Issue 24; Pages: 6195
Therapies with the mechanistic target of rapamycin complex 1 (mTORC1) inhibitors are not fully curative for tuberous sclerosis complex (TSC) patients. Here, we propose that some mTORC1-independent disease facets of TSC involve signaling through redox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a649a247cc5a0102d117b241c81851
https://doi.org/10.3390/cancers14246195
https://doi.org/10.3390/cancers14246195
Autor:
P J Stanczyk, Junaid Kashir, Brian L. Calver, Francis Anthony Lai, A Satgunarajah, C Morgan, Leon D’Cruz, SA Husain, T Wells, Lynda Blayney
Publikováno v:
Journal of Aging Research and Lifestyle. :1-8
Objectives: Does excessive sun-exposure, non-use of sunscreen and/or high doses of vitamin-D3 supplements provoke exacerbation of asthma? Design: Clinical examinations, retrospective records-access and questionnaire surveys were distributed to a conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d504a348fece846e4e961e4073f50350
https://doi.org/10.14283/jarcp.2018.10
https://doi.org/10.14283/jarcp.2018.10
Autor:
Gheyath K. Nasrallah, Ali Al-Maraghi, Alaaeldin Saleh, Egon Toft, Brian L. Calver, George Nounesis, Rola Salem, Bared Safieh-Garabedian, F. Anthony Lai, Michail Nomikos, Angelos Thanassoulas, Sahar I. Da'as
Calmodulin (CaM) is a multifunctional calcium (Ca2+)-binding messenger that directly interacts with the cardiac ryanodine receptor 2 (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic reticulum to activate car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde2d8314483c7e93e56bca18f8372a2
https://hdl.handle.net/10576/24202
https://hdl.handle.net/10576/24202
Autor:
David Sanders, Adnan Bunkheila, Peter Ashley, F. Anthony Lai, Michail Nomikos, Panagiotis Stamatiadis, Evangelia Livaniou, Vyronia Vassilakopoulou, Paul Knaggs, Karl Swann, Junaid Kashir, Luke Buntwal, Brian L. Calver
Publikováno v:
Molecular Human Reproduction. 23:54-67
Study Question\ud Is it possible to improve clinical visualization of phospholipase C zeta (PLCζ) as a diagnostic marker of sperm oocyte activation capacity and male fertility?\ud Summary Answer\ud Poor PLCζ visualization efficacy using current pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7da24205326e26f627bbbebef51321
https://doi.org/10.1093/molehr/gaw073
https://doi.org/10.1093/molehr/gaw073
Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function
Autor:
Jasmine Kew, Konrad Beck, Zili Sideratou, Maria Theodoridou, Pierre J. Rizkallah, George Nounesis, Brian L. Calver, F. Anthony Lai, Michail Nomikos, Angelos Thanassoulas, Junaid Kashir, Emily Matthews
Publikováno v:
The FEBS Journal. 283:4502-4514
Hereditary leukonychia is a rare genetic nail disorder characterized by distinctive whitening of the nail plate of all 20 nails. Hereditary leukonychia may exist as an isolated feature, or in simultaneous occurrence with other cutaneous or systemic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7186b4edf053f6b626b86a4e65d4242
https://doi.org/10.1111/febs.13939
https://doi.org/10.1111/febs.13939
Autor:
George Nounesis, F. Anthony Lai, Angelos Thanassoulas, Michail Nomikos, Evangelia Livaniou, Bared Safieh-Garabedian, Vyronia Vassilakopoulou, Egon Toft, Brian L. Calver
Publikováno v:
Biophysical Journal. 118:565a
Ryanodine receptor 2 (RyR2) is a large transmembrane calcium (Ca2+) release channel that mediates Ca2 release from the sarcoplasmic reticulum to activate cardiac muscle contraction. Calmodulin (CaM) regulation of RyR2 is essential for normal cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd23ed237c4bd8844ed6e5c64e2105b
https://doi.org/10.1016/j.bpj.2019.11.3081
https://doi.org/10.1016/j.bpj.2019.11.3081
Autor:
Brian L. Calver, Khalid A. Fakhro, Sahar I. Da'as, F. Anthony Lai, Navaneethakrishnan Krishnamoorthy, Bared Safieh-Garabedian, Angelos Thanassoulas, Michail Nomikos, Alaaeldin Saleh, George Nounesis, Egon Toft
The most common inherited cardiac disorder, hypertrophic cardiomyopathy (HCM), is characterized by thickening of heart muscle, for which genetic mutations in cardiac myosin-binding protein C3 (c-MYBPC3) gene, is the leading cause. Notably, patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175c6e027ed196c68baf4df6decdc64f
https://hdl.handle.net/10576/11927
https://hdl.handle.net/10576/11927
Autor:
Lynda Blayney, Michail Nomikos, Junaid Kashir, Brian L. Calver, Adrian Smith, F. Anthony Lai, Evangelia Livaniou, Angelos Thanassoulas, Handan Hu, Konrad Beck, George Nounesis, Vyronia Vassilakopoulou, Maria Theodoridou, Luke Buntwal
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1850:2168-2176
Calmodulin (CaM) is a cytoplasmic calcium sensor that interacts with the cardiac ryanodine receptor (RyR2), a large Ca2 + channel complex that mediates Ca2 + efflux from the sarcoplasmic reticulum (SR) to activate cardiac muscle contraction. Direct C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aba3012bcc260e54be74eed98259764
https://doi.org/10.1016/j.bbagen.2015.07.001
https://doi.org/10.1016/j.bbagen.2015.07.001