Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Brian Kevin Park"'
Autor:
Eric Austin, Jon Smythe, Brian Kevin Park, Jack Sharkey, Harish Poptani, Patricia Murray, Joan Comenge, Michael Barrow, Dave J. Adams, Raphaël Lévy, Cai Astley, Bettina Wilm, Rachel Harwood, Ilaria Santeramo, Arthur Taylor, Claire Hutchinson, Lydia Beeken, Lauren Scarfe, Lorenzo Ressel, Matthew J. Rosseinsky
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-17 (2018)
STEM CELL RESEARCH & THERAPY
Stem Cell Research and Therapy
Stem Cell Research & Therapy
STEM CELL RESEARCH & THERAPY
Stem Cell Research and Therapy
Stem Cell Research & Therapy
BackgroundCell-based regenerative medicine therapies are now frequently tested in clinical trials. In many conditions, cell therapies are administered systemically, but there is little understanding of their fate, and adverse events are often under-r
Morphological and Mechanistic Aspects of Thiourea-Induced Acute Lung Injury and Tolerance in the Rat
Publikováno v:
Toxicologic Pathology
Thiourea-based molecules cause pulmonary edema when administered to rats at relatively low doses. However, rats survive normally lethal doses after prior exposure to a lower, nonlethal dose; this phenomenon is known as tolerance. The present study in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436616c3f225ebb5a7b3c83a886ec524
https://doi.org/10.5167/uzh-190411
https://doi.org/10.5167/uzh-190411
Autor:
Neil G. Berry, Paul Whitaker, Anthony W. Purcell, Dean J. Naisbitt, Patricia T. Illing, Brian Kevin Park, Kareena Adair, Jane Hamlett, J. C. Waddington, Rosalind E. Jenkins, Arun Tailor, John Farrell, Xiaoli Meng
Publikováno v:
TOXICOLOGICAL SCIENCES
Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver reactions. Although expression of human leukocyte antigen (HLA)-B*57:01 increases susceptibility, little is known of the pathological mechanisms involved
Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds
Autor:
Joel Watkinson, Melanie Z. Sakatis, Monday O. Ogese, Brian Kevin Park, Dean J. Naisbitt, Adam Lister, Lee Faulkner, Andrew Gibson, Aimee Hillegas
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology
The prediction of drug hypersensitivity is difficult due to the lack of appropriate models and known risk factors. In vitro naïve T-cell priming assays that assess immunogenicity have been developed. However, their application is limited due require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e56eca85252027716f1816875dba21e
Autor:
Carmen Pin, Julio Saez-Rodriguez, Laura I. Furlong, Ciarán Fisher, Loic Laplanche, Panuwat Trairatphisan, Sofia Ferreira, Brian Kevin Park
Publikováno v:
Chemical Research in Toxicology
Omics data have been increasingly generated with limited demonstrated value in drug safety assessment. The TransQST consortium was launched to use omics and other data in mechanistic-based quantitative systems toxicology (QST) models to evaluate thei
Autor:
Neil R. Kitteringham, Triantafillos Liloglou, Joseph R. Slupsky, Thompson Gana, Adedamola Olayanju, Wafa AbuAlainin, John P. Neoptolemos, Timothy Andrews, Taoufik Nedjadi, Christopher E. Goldring, Michael C. Schmid, Fiona Campbell, Eithne Costello, Brian Kevin Park, Lawrence N. Barrera, William Greenhalf, Robert Ferguson
Publikováno v:
The Journal of Pathology
The cellular defence protein Nrf2 is a mediator of oncogenesis in pancreatic ductal adenocarcinoma (PDAC) and other cancers. However, the control of Nrf2 expression and activity in cancer is not fully understood. We previously reported the absence of
Autor:
Joan Comenge, Oihane Fragueiro, Jack Sharkey, Arthur Taylor, Marie Held, Neal C. Burton, Brian Kevin Park, Bettina Wilm, Patricia Murray, Mathias Brust, Raphaël Lévy
Publikováno v:
ACS nano. 12(8)
Autor:
Rosalind E. Jenkins, Emanuele Ricci, Brian Kevin Park, Teresa Ravizza, Thimmasettappa Thippeswamy, Tiina Alapirtti, Lauren Walker, Anthony G Marson, Karen Tse, Luca Porcu, Graeme J. Sills, Andrea L. Jorgensen, Munir Pirmohamed, Annamaria Vezzani, Jukka Peltola, Federica Frigerio, Daniel J. Antoine, Martin J. Brodie
Publikováno v:
Walker, L E, Frigerio, F, Ravizza, T, Ricci, E, Tse, K, Jenkins, R E, Sills, G J, Jorgensen, A L, Porcu, L, Thippeswamy, T, Alapirtti, T, Peltola, J, Brodie, M J, Park, B K, Marson, A G, Antoine, D, Vezzani, A & Pirmohamed, M 2017, ' Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy ', Journal of Clinical Investigation, vol. 127, no. 6, pp. 2118-2132 . https://doi.org/10.1172/JCI92001
The Journal of Clinical Investigation
Journal of Clinical Investigation
The Journal of Clinical Investigation
Journal of Clinical Investigation
Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role in drug-resistant epilepsy. The high-mobility group box 1 (HMGB1)/TLR4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e482961da99a8a00124bb7175367d49b
https://www.pure.ed.ac.uk/ws/files/55789774/Antoine_D_Molecular_isoforms....pdf
https://www.pure.ed.ac.uk/ws/files/55789774/Antoine_D_Molecular_isoforms....pdf
Autor:
Catherine J. Betts, Neil French, Lee Faulkner, Dean J. Naisbitt, Mohamed Elmasry, Christopher E. Goldring, Brian Kevin Park, Ian M. Copple, Roz Jenkins, Daniel J. Antoine, Hasan Malik, Monday O. Ogese
Publikováno v:
TOXICOLOGICAL SCIENCES
It is now apparent that antigen-specific T-cells are activated in certain patients with drug-induced liver injury (DILI). Since cross-talk between hepatocytes and immune cells is likely to be critical in determining the outcome of drug exposure, the
Autor:
Joan, Comenge, Oihane, Fragueiro, Jack, Sharkey, Arthur, Taylor, Marie, Held, Neal C, Burton, Brian Kevin, Park, Bettina, Wilm, Patricia, Murray, Mathias, Brust, Raphaël, Lévy
Publikováno v:
ACS nano. 10(7)
Gold nanorods are excellent contrast agents for imaging technologies which rely on near-infrared absorption such as photoacoustic imaging. For cell tracking applications, the cells of interest are labeled with the contrast agent prior to injection. H