Výsledky vyhledávání - "Brian Kent Rhees"

An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial

Autor: Mark Monane, Udo Hoffmann, Pamela S. Douglas, Brian Kent Rhees, Kerry L. Lee, Lin Huang, Svati H. Shah, Geoffrey S. Ginsburg, William E. Kraus, Steven A. Rosenberg, Deepak Voora, Susan E. Daniels, Adrian Coles, James A. Wingrove

Publikováno v: American Heart Journal. 184:133-140

Identifying predictors of coronary artery disease (CAD)-related procedures and events remains a priority.We measured an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive CAD (oCAD) in symptomatic nondiabet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0953f77c901961dd84b2547b1c9b1c7f

Zobrazit plný text záznamu

Peripheral blood gene expression signatures which reflect smoking and aspirin exposure are associated with cardiovascular events

Autor: Brian Kent Rhees, Karen Fitch, James A. Wingrove, Deepak Voora, Steven A. Rosenberg

Publikováno v: BMC Medical Genomics
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-9 (2018)

Background Cardiovascular disease and its sequelae are major causes of global mortality, and better methods are needed to identify patients at risk for future cardiovascular events. Gene expression analysis can inform on the molecular underpinnings o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079d6773e1bbeae12231e4c7034c7a2d
https://doi.org/10.1186/s12920-017-0318-6

Zobrazit plný text záznamu

Plný text ve formátu HTML

Biological and Analytical Stability of a Peripheral Blood Gene Expression Score for Obstructive Coronary Artery Disease in the PREDICT and COMPASS Studies

Autor: Gregory S. Thomas, Brian Kent Rhees, Susan E. Daniels, Steven A. Rosenberg, Philip Beineke, William E. Kraus, John A. McPherson

Publikováno v: Journal of Cardiovascular Translational Research

A gene expression score (GES) for obstructive coronary artery disease (CAD) has been validated in two multicenter studies. Receiver-operating characteristics (ROC) analysis of the GES on an expanded Personalized Risk Evaluation and Diagnosis in the C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bab3cc13e7f5e5e50edcf6dd72a0472
https://doi.org/10.1007/s12265-014-9583-3

Zobrazit plný text záznamu

Assessment of Clinical Validity of a Breast Cancer Risk Model Combining Genetic and Clinical Information

Autor: Renee Stokowski, David A. Hinds, Brian Kent Rhees, Matthew E. Mealiffe, Ross L. Prentice, Mary Pettinger

Publikováno v: JNCI Journal of the National Cancer Institute

Background The Gail model is widely used for the assessment of risk of invasive breast cancer based on recognized clinical risk factors. In recent years, a substantial number of single-nucleotide polymorphisms (SNPs) associated with breast cancer ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5298adf66bb7b6943f7c25b4367fa95
http://europepmc.org/articles/PMC2970578

Zobrazit plný text záznamu

Genetic Variation in Candidate Osteoporosis Genes, Bone Mineral Density, and Fracture Risk: The Study of Osteoporotic Fractures

Autor: Gary Peltz, Marc C. Hochberg, Teresa A. Hillier, Li Yung Lui, Kristine E. Ensrud, Brian Kent Rhees, Henry A. Erlich, Jia Li, Jane A. Cauley, Mark D. Sternlicht, Brent C Taylor, Joseph M. Zmuda, Steven R. Cummings, Gregory J. Tranah

Publikováno v: Calcified Tissue International. 83:155-166

Candidate osteoporosis gene variants were examined for associations with fracture risk and bone mineral density (BMD). A total of 9,704 white women were recruited at four U.S. clinical centers and enrolled into the Study of Osteoporotic Fractures, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a23ed3d38f39a6a70b249662c19dc35
https://doi.org/10.1007/s00223-008-9165-y

Zobrazit plný text záznamu

The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle

Autor: W Venus So, Steven M. Willi, Michael V. Osier, Grier P. Page, Xiangqin Cui, Jim Rosinski, Xuxia Wu, Jelai Wang, Lidia Maianu, Helliner S. Hill, David B. Allison, W. Timothy Garvey, Mitchell Martin, Brian Kent Rhees

Publikováno v: Endocrine. 31:5-17

To study the insulin effects on gene expression in skeletal muscle, muscle biopsies were obtained from 20 insulin sensitive individuals before and after euglycemic hyperinsulinemic clamps. Using microarray analysis, we identified 779 insulin-responsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429c27320ce8be56f0d9e015aa2134dc
https://doi.org/10.1007/s12020-007-0007-x

Zobrazit plný text záznamu

Estrogen receptor alpha haplotypes and breast cancer risk in older Caucasian women

Autor: Jun Wang, Francesmary Modugno, J Tice, Elad Ziv, Steven R. Cummings, Nanette Umblas, Jia Li, Li-Yung Lui, Jocelyn M. Lee, Russell Higuchi, Brian Kent Rhees

Publikováno v: Breast Cancer Research and Treatment. 106:273-280

Life-long exposure to estrogen is an established risk factor for breast cancer development. The underlying mechanism has been suggested to be the binding of estrogen-to-estrogen receptors in mammary tissue, which in turn promotes the proliferation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e01dcf8c03294606bf813468c433d02
https://doi.org/10.1007/s10549-007-9497-8

Zobrazit plný text záznamu

Abstract 407: Use of a Previously Validated Blood-based Test Demonstrates Increased Diagnostic Accuracy as Measured by AUC over Usual Care in the Evaluation of Obstructive Coronary Artery Disease in Males and Females

Autor: Mark Monane, Robert Honigberg, Alexandra J. Lansky, Matthew J. Budoff, James A. Wingrove, John A. McPherson, Brian Kent Rhees, Andrea Johnson

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 35

Background: Current evaluation of stable, non-acute patients presenting with symptoms suggestive of obstructive coronary artery disease (CAD) is costly and often exposes patients to radiation and contrast-dye side effects. These risks are coupled wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74bef089b1bfa660f7463c420d05ac55
https://doi.org/10.1161/atvb.35.suppl_1.407

Zobrazit plný text záznamu

Use of a blood test incorporating age, sex, and gene expression influences medical decision-making in the evaluation of women presenting with symptoms suggestive of obstructive coronary artery disease: summary results from two ambulatory care studies in primary care

Autor: Lon Castle, Mark Monane, Brian Kent Rhees, John A. McPherson, Bonnie H. Weiner, Joseph A. Ladapo, Lee Herman

Publikováno v: Menopause (New York, N.Y.). 22(11)

OBJECTIVE Clinicians need better approaches to evaluating women at midlife and beyond who present to primary care with chest pain and related symptoms. A previously validated blood-based test, which includes age, sex, and gene expression levels, show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f51b4ceacd0fbfe541f2d33c848155
https://pubmed.ncbi.nlm.nih.gov/25828395

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání