Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Brian K. Reuter"'
Autor:
Ruo Jia, Loris Riccardo Lopetuso, Brian K. Reuter, Fabio Cominelli, Wendy A. Goodman, Jon Meddings, Xiao-Ming Wang, Valentina Petito, Theresa T. Pizarro, Li Guo Jia
Publikováno v:
Inflammatory bowel diseases. 23(3)
Background A large body of evidence supports a central role of TLR5 and its natural ligand, flagellin, in Crohn's disease (CD), with the precise mechanism(s) still unresolved. Methods We investigated the role of flagellin/TLR5 in SAMP1/YitFc (SAMP) m
Autor:
Benedetta Mattioli, Brian K. Reuter, Wendy A. Goodman, Theresa T. Pizarro, Rekha R. Garg, Emilie F. Rissman
Publikováno v:
Mucosal immunology
The incidence and severity of Crohn's disease (CD) are increased in female patients. Using SAMP1/YitFc (SAMP) mice, a spontaneous model of chronic intestinal inflammation that displays histologic and pathogenic similarities to human CD, we investigat
Autor:
Brian K. Reuter, Lindon H. Young, Alita Zabrecky, Robert Barsotti, Amber N. Koon, Hung Pham, Qian Chen
Publikováno v:
The FASEB Journal. 30
Autor:
Peter B. Ernst, Robert M. Rowlett, Sheila E. Crowe, Joel Linden, Mohammad S. Alam, Brian K. Reuter, Courtney C. Kurtz, Soumita Das, Elizabeth B. Wiznerowicz
Publikováno v:
The Journal of Infectious Diseases. 199:494-504
Regulatory T cells (known as "Treg") express apyrases (CD39) and ecto-5'-nucleotidase (CD73) and contribute to their inhibitory function by generating adenosine. We investigated the expression of CD39 and CD73 on human T helper (Th) cells and the rol
Autor:
Leslie N. Hancock, Theresa T. Pizarro, Kevin Scott, Timothy S. Olson, Klaus Ley, Jonathan B. Meddings, Peter B. Ernst, Margaret A. Morris, Steven M. Cohn, Fabio Cominelli, Xiao-Ming Wang, Tracy L. Burcin, Brian K. Reuter
Publikováno v:
The Journal of Experimental Medicine
The initiating etiologic factor in Crohn's disease (CD) remains unclear. SAMP1/YitFc (SAMP) mice develop chronic ileitis similar to human CD. We used bone marrow chimeras to determine if SAMP ileitis results from a primary immunological defect or fro
Publikováno v:
Gastroenterology. 119:706-714
Background & Aims: Selective cyclooxygenase (COX)-2 inhibitors produce less gastric damage than conventional nonsteroidal anti-inflammatory drugs (NSAIDs), suggesting that NSAIDs cause damage by inhibiting COX-1. We tested this hypothesis in rats by
Publikováno v:
Journal of Gastroenterology and Hepatology. 13:S266-S269
Publikováno v:
Journal of Gastroenterology and Hepatology. 13:S266-S269
Prostaglandins appear to play an important role in down-regulating intestinal inflammation and promoting repair of injury. In experimental colitis, inhibition of prostaglandin synthesis with nonsteroidal anti-inflammatory drugs (NSAID) leads to marke
Publikováno v:
Journal of Clinical Gastroenterology. 27:S28-S34
Selective inhibitors of the "inducible" isoform of cyclooxygenase (COX-2) have been suggested to be effective analgesic and anti-inflammatory drugs while sparing the gastrointestinal (GI) tract of injury. There is some experimental and early clinical
Autor:
Keith A. Sharkey, A. W. Tigley, JoséGeraldo P. Ferraz, Samuel Asfaha, Brian K. Reuter, M. L. Brown, John L. Wallace, Webb McKnight
Publikováno v:
Gastroenterology. 113:195-204
BACKGROUND & AIMS: Prostaglandins and nitric oxide are key mediators of gastric mucosal defense. Endotoxemia alters gastric resistance to damage, but little is known of the effects of chronic endotoxemia on the expression of prostaglandin and nitric