Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Brian K. May"'
Autor:
A.J. Moore, Rebecca Sawyer, Peter D. O’Loughlin, Brian K. May, Paul H. Anderson, Howard A. Morris
Publikováno v:
Journal of Bone and Mineral Research. 23:1789-1797
The association between increased risk of hip fracture and low vitamin D status has long been recognized. However, the level of vitamin D required to maintain bone strength is controversial. We used a rodent model of vitamin D depletion to quantify t
Autor:
Joseph Tan, Charles S. T. Hii, Antonio Ferrante, Paul H. Anderson, Brian K. May, Peter D. O’Loughlin, Barbara K. Nutchey, Howard A. Morris, Prem P. Dwivedi
Publikováno v:
Molecular Cancer Therapeutics. 6:3131-3138
Calcitriol or 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] has antitumor activity and hence its levels in patients may play an important role in disease outcome. Here, we report that the antineoplastic agents, daunorubicin hydrochloride, etoposide, and vin
25-Hydroxyvitamin D requirement for maintaining skeletal health utilising a Sprague-Dawley rat model
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 103:592-595
To study the role of vitamin D to optimise bone architecture, we have developed an animal model to investigate the effects of frank vitamin D-deficiency as well as graded depletion of circulating 25-hydroxyvitamin D(3) (25D) levels on the skeleton. R
Publikováno v:
Biochemical Journal. 392:173-180
Haem is essential for the health and function of nearly all cells. 5-Aminolaevulinic acid synthase-1 (ALAS-1) catalyses the first and rate-controlling step of haem biosynthesis. ALAS-1 is repressed by haem and is induced strongly by lipophilic drugs
Publikováno v:
Bone. 36:654-662
Circulating levels of 1,25-dihydroxyvitamin D (1,25D) are determined by bioactivation catalyzed by the renal 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1) and degradation through the action of the renal 25-hydroxyvitamin D 24-hydroxylase (CYP24).
Publikováno v:
European Journal of Biochemistry. 129:615-620
5-Aminolaevulinate synthase from chick-embryo liver mitochondria has, for the first time, been purified to homogeneity in its native non-degraded form by molecular sieve chromatography, chromatofocusing and affinity chromatography. The enzyme has a m
Publikováno v:
European Journal of Biochemistry. 106:17-24
Polyadenylated mRNA was isolated from chick embryo liver following induction of hepatic porphyria. The RNA was translated in vitro using a wheat germ cell-free system and delta-aminolaevulinate synthase was identified in the translation products by i
Autor:
Sylvia S. Bottomley, Quenten Schwarz, Liza L Cox, Phillip D Wise, Christopher S Matthews, Brian K. May, Timothy C. Cox, Timothy Sadlon
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 36:281-295
The initial step of the heme biosynthetic pathway in erythroid cells is catalyzed by an erythroid-specific isoform of 5-aminolevulinate synthase-2 (ALAS2). Previously, an alternatively spliced mRNA isoform of ALAS2 was identified although the functio
Autor:
Brian K. May, Howard A. Morris, Charles S. T. Hii, Antonio Ferrante, Joseph Cheng-Ta Tan, Prem P. Dwivedi, Channing J. Der, John L. Omdahl
Publikováno v:
Journal of Biological Chemistry. 277:29643-29653
The current study investigated the action of 1,25-dihydroxyvitamin D3 (1,25D) at the genomic and signal transduction levels to induce rat cytochrome P450C24 (CYP24) gene expression. A rat CYP24 promoter containing two vitamin D response elements and
Publikováno v:
Molecular Pharmacology. 60:274-281
The cytochrome P450 gene CYP2H1 is highly induced by phenobarbital in chick embryo hepatocytes. Recent studies have established that the orphan nuclear receptor CAR plays a critical role in the induction mechanism. Here, we show that a high concentra