A common variant associated with prostate cancer in European and African populations

Autor: Olafia S Gretarsdottir, Jelena Kostic, Kari Agnarsson, Carole Ober, Unnur Thorsteinsdottir, James E. Montie, Bjarni A. Agnarsson, Kristleifur Kristjansson, Adalheidur Olafsdottir, Jon Thor Bergthorsson, Daniel F. Gudbjartsson, William J. Catalona, Rosa B. Barkardottir, Jeffrey R. Gulcher, Adam Baker, Katarina Bälter, Margret Jakobsdottir, Jesus Sainz, Gudmundur Geirsson, Helgi J Isaksson, Julius Gudmundsson, Thorarinn Blondal, Kristrun R. Benediktsdottir, Louise le Roux, Gudmar Thorleifsson, Patrick Sulem, Fredrik Wiklund, Jean-Baptiste Cazier, Margret B. Andresdottir, Shyamali Ghosh, Julie A. Douglas, Laufey T. Amundadottir, Kari Stefansson, Kathleen A. Cooney, Arnaldur Gylfason, Andrei Manolescu, Gudmundur V. Einarsson, Droplaug N Magnusdottir, Augustine Kong, Asgeir Sigurdsson, Jan-Erik Johansson, Birgitta Birgisdottir, Agnar Helgason, Henrik Grönberg, Brian K. Suarez, Xiaoying Yu

With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7306dc429cda53e2d468cad0f2085cbe
https://ora.ox.ac.uk/objects/uuid:67a73a19-78e6-472e-9208-dba20f956bc2

Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma

Autor: Sarah D. Isaacs, Sonja I. Berndt, Aleksandra Klim, Carol H. Jin, Brian K. Suarez, William B. Isaacs, Adam S. Kibel, Jessica D. Lubahn, William Wu, Richard B. Hayes, Jason Luly, Kathleen E. Wiley

Publikováno v: The Prostate. 70:646-653

BACKGROUND Because of the dramatically different clinical course of aggressive and indolent prostate carcinoma (PCa), markers that distinguish between these phenotypes are of critical importance. Apoptosis is an important protective mechanism for unr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ddf393d3baf411b5f6a468dd7fca70c
https://doi.org/10.1002/pros.21098

Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin

Autor: Ranjan Deka, William J. Catalona, Carol H. Jin, Brian K. Suarez, Prodipto Pal, Ritesh Kaushal, Joshua J. Meeks, C. Shad Thaxton, Saurav Guha, Huifeng Xi, Guangyun Sun

Publikováno v: Human Genetics. 122:251-259

Two of the classical kallikrein genes KLK3 and KLK2 on 19q13.4 are plausible candidates in prostate cancer susceptibility. They are expressed almost exclusively in prostate tissue. We have performed a comprehensive analysis of association of variants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0bd5ee55570a8864538ecc36c9445e
https://doi.org/10.1007/s00439-007-0394-3

Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics

Autor: Daniel J, Schaid, Shannon K, McDonnell, Katherine E, Zarfas, Julie M, Cunningham, Scott, Hebbring, Stephen N, Thibodeau, Rosalind A, Eeles, Douglas F, Easton, William D, Foulkes, Jacques, Simard, Graham G, Giles, John L, Hopper, Lovise, Mahle, Pal, Moller, Michael, Badzioch, D Timothy, Bishop, Chris, Evans, Steve, Edwards, Julia, Meitz, Sarah, Bullock, Questa, Hope, Michelle, Guy, Chih-lin, Hsieh, Jerry, Halpern, Raymond R, Balise, Ingrid, Oakley-Girvan, Alice S, Whittemore, Jianfeng, Xu, Latchezar, Dimitrov, Bao-Li, Chang, Tamara S, Adams, Aubrey R, Turner, Deborah A, Meyers, Danielle M, Friedrichsen, Kerry, Deutsch, Suzanne, Kolb, Marta, Janer, Leroy, Hood, Elaine A, Ostrander, Janet L, Stanford, Charles M, Ewing, Marta, Gielzak, Sarah D, Isaacs, Patrick C, Walsh, Kathleen E, Wiley, William B, Isaacs, Ethan M, Lange, Lindsey A, Ho, Jennifer L, Beebe-Dimmer, David P, Wood, Kathleen A, Cooney, Daniela, Seminara, Tarja, Ikonen, Agnes, Baffoe-Bonnie, Henna, Fredriksson, Mika P, Matikainen, Teuvo L J, Tammela, Joan, Bailey-Wilson, Johanna, Schleutker, Christiane, Maier, Kathleen, Herkommer, Josef J, Hoegel, Walther, Vogel, Thomas, Paiss, Fredrik, Wiklund, Monica, Emanuelsson, Elisabeth, Stenman, Björn-Anders, Jonsson, Henrik, Grönberg, Nicola J, Camp, James, Farnham, Lisa A, Cannon-Albright, William J, Catalona, Brian K, Suarez, Kimberly A, Roehl

Publikováno v: Human Genetics. 120:471-485

While it is widely appreciated that prostate cancers vary substantially in their propensity to progress to a life-threatening stage, the molecular events responsible for this progression have not been identified. Understanding these molecular mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea13fe9f0191be0e734237520ba9a855
https://doi.org/10.1007/s00439-006-0219-9

Baseline prostate-specific antigen compared with median prostate-specific antigen for age group as predictor of prostate cancer risk in men younger than 60 years old

Autor: William J. Catalona, Robert B. Nadler, Kimberly A. Roehl, Brian K. Suarez, Jo Ann V. Antenor, Stacy Loeb

Publikováno v: Urology. 67:316-320

Objectives Limited data are available concerning the extent to which the initial prostate-specific antigen (PSA) measurement in men younger than age 60 predicts for the risk of prostate cancer (CaP) and how this compares to other known risk factors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537a749d573c78062f7c62b472cef3c3
https://doi.org/10.1016/j.urology.2005.08.040