Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Brian K Flesner"'
Autor:
Andi Flory, Kristina M Kruglyak, John A Tynan, Lisa M McLennan, Jill M Rafalko, Patrick Christian Fiaux, Gilberto E Hernandez, Francesco Marass, Prachi Nakashe, Carlos A Ruiz-Perez, Donna M Fath, Thuy Jennings, Rita Motalli-Pepio, Kate Wotrang, Angela L McCleary-Wheeler, Susan Lana, Brenda Phillips, Brian K Flesner, Nicole F Leibman, Tracy LaDue, Chelsea D Tripp, Brenda L Coomber, J Paul Woods, Mairin Miller, Sean W Aiken, Amber Wolf-Ringwall, Antonella Borgatti, Kathleen Kraska, Christopher B Thomson, Alane Kosanovich Cahalane, Rebecca L Murray, William C Kisseberth, Maria A Camps-Palau, Franck Floch, Claire Beaudu-Lange, Aurélia Klajer-Peres, Olivier Keravel, Luc-André Fribourg-Blanc, Pascale Chicha Mazetier, Angelo Marco, Molly B McLeod, Erin Portillo, Terry S Clark, Scott Judd, C Kirk Feinberg, Marie Benitez, Candace Runyan, Lindsey Hackett, Scott Lafey, Danielle Richardson, Sarah Vineyard, Mary Tefend Campbell, Nilesh Dharajiya, Taylor J Jensen, Dirk van den Boom, Luis A Diaz, Daniel S Grosu, Arthur Polk, Kalle Marsal, Susan Cho Hicks, Katherine M Lytle, Lauren Holtvoigt, Jason Chibuk, Ilya Chorny, Dana W Y Tsui
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266623 (2022)
Cancer is the leading cause of death in dogs, yet there are no established screening paradigms for early detection. Liquid biopsy methods that interrogate cancer-derived genomic alterations in cell-free DNA in blood are being adopted for multi-cancer
Externí odkaz:
https://doaj.org/article/941919387dec4012ae30e0d3a5f983c6
Autor:
Carlos A. Ruiz-Perez, Prachi Nakashe, Maggie A. Marshall, Francesco Marass, Tuong Tang, Lisa M. McLennan, Marissa Kroll, Brian K. Flesner, Suzanne Gray, Jill M. Rafalko, Daniel S. Grosu, Susan C. Hicks, John A. Tynan, Dana W.Y. Tsui, Andi Flory, Kristina M. Kruglyak
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
This proof-of-concept evaluation demonstrates that next-generation sequencing-based liquid biopsy can detect genomic alterations in the blood of cats with cancer and the absence of such alterations in the blood of presumably cancer-free cats. Two cat
Externí odkaz:
https://doaj.org/article/574a27c2e3a84f46ba3a5b5f33382d63
Autor:
Sandra M. Axiak‐Bechtel, Stacey B. Leach, Jessica R. Newton‐Northup, Rowan J. Milner, Stacey A. Fox‐Alvarez, Lana I. Fagman, Kaylee A. Young, Deborah J. Tate, Zachary M. Wright, John D. Chretin, Justin W. Allen, Sean K. Yoshimoto, Kimberly A. Selting, Brian K. Flesner, Carrie R. White, Tracy Mills, Michael Aherne, Philip J. Bergman, LeAnn Qi, Kenneth A. Gruber, Michael F. Callahan
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 37, Iss 6, Pp 2344-2355 (2023)
Abstract Background The melanocortin 4 antagonist TCMCB07 is safe and effective in reversing cachexia caused by sepsis or cancer in rodents. The safety and pharmacokinetics of TCMCB07 are demonstrated in healthy beagle dogs. Hypothesis/Objectives The
Externí odkaz:
https://doaj.org/article/15500eb735e64a8094068773cb02e744
Autor:
Carissa J. Norquest, Anita Rogic, Phyllis A. Gimotty, Charles A. Maitz, Hansjorg Rindt, Hayley L. Ashworth, Jeffrey N. Bryan, Lindsay L. Donnelly, Angela L. McCleary-Wheeler, Brian K. Flesner
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionZoledronic acid (ZOL) is a third-generation bisphosphonate with a higher affinity for bone resorption areas than earlier bisphosphonates (i.e., pamidronate, PAM). In human medicine, ZOL provides improved bone pain relief and prolonged tim
Externí odkaz:
https://doaj.org/article/bde0331aac46404291b83e663e3169b2
Autor:
Elizabeth A. F. Schaefer, Shirley Chu, Kristine M. Wylie, Todd N. Wylie, Obi L. Griffith, Jacqueline W. Pearce, Gayle C. Johnson, Jeffrey N. Bryan, Brian K. Flesner
Publikováno v:
Microorganisms, Vol 11, Iss 5, p 1163 (2023)
Our study aims are: (1) to evaluate phenotypically normal canine conjunctival and orbital tissue and tissue from canine lobular orbital adenomas (CLOAs) for the presence of viral genomic material and (2) phylogenetically classify detected DNA viruses
Externí odkaz:
https://doaj.org/article/ae4e86c06eeb484e88440ebae94dd6b7
Autor:
Brian K. Flesner, Gary W. Wood, Pamela Gayheart‐Walsten, F. Lynn Sonderegger, Carolyn J. Henry, Deborah J. Tate, Sandra M. Bechtel, Lindsay L. Donnelly, Gayle C. Johnson, Dae Young Kim, Tammie A. Wahaus, Jeffrey N. Bryan, Noe Reyes
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 34, Iss 5, Pp 2056-2067 (2020)
Abstract Background Osteosarcoma (OSA) in dogs is an aggressive bone tumor with frequent chemotherapy failure and translational relevance for human health. Hypothesis/Objectives We hypothesized that dogs with OSA could be treated safely by ex vivo ac
Externí odkaz:
https://doaj.org/article/5f14414e5acc4b1e977d921c71fc0402
Autor:
Brian K. Flesner, Bryan T. Torres, Kyle D. Hutcheson, Hansjörg Rindt, Amy R. Zalcman, Charles A. Maitz
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Cancer-induced bone pain, despite its frequency and severity, is a poorly understood phenomenon in people and animals. Despite excitement regarding translational osteosarcoma studies, there is a lack of attention toward examining cancer pain in dogs.
Externí odkaz:
https://doaj.org/article/fc68661e38204cab9335bfbb5ecdc7b5
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Chemotherapy overdoses (ODs) are severe complications that can occur following the use of antineoplastics. However, little is known about chemotherapy ODs in veterinary medicine. The goals of this retrospective study were to report the occurrence, ty
Externí odkaz:
https://doaj.org/article/b15806da56934e10a29218641e2e4d9a
Autor:
Elizabeth A. F. Schaefer, Shirley Chu, Jacqueline W. Pearce, Jeffrey N. Bryan, Brian K. Flesner
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-8 (2019)
Abstract Background Canine lobular orbital adenomas are benign tumors that arise from orbital glandular tissue and extend into the orbit, conjunctiva, and third eyelid. Surgical excision is challenging and recurrence rates are high following excision
Externí odkaz:
https://doaj.org/article/80ab9206cfd540bbbc3bb8ebfe4c384a
Autor:
Amy K. LeBlanc, Christina N. Mazcko, Timothy M. Fan, David M. Vail, Brian K. Flesner, Jeffrey N. Bryan, Shan Li, Feng Wang, Scott Harris, Jesse D. Vargas, Jeevan P. Govindharajulu, Soumya Jaganathan, Francesca Tomaino, Apurva K. Srivastava, Tsui-Fen Chou, Gordon M. Stott, Joseph M. Covey, Barbara Mroczkowski, James H. Doroshow
Publikováno v:
Mol Cancer Ther
Pet dogs with naturally occurring cancers play an important role in studies of cancer biology and drug development. We assessed tolerability, efficacy, and pharmacokinetic/pharmacodynamic relationships with a first-in-class small molecule inhibitor o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c565201e4fd1dfd7a87c1b7df5687b36
https://doi.org/10.1158/1535-7163.mct-22-0167
https://doi.org/10.1158/1535-7163.mct-22-0167