Zobrazeno 1 - 10
of 398
pro vyhledávání: '"Brian K, Kobilka"'
Autor:
Yosuke Toyoda, Angqi Zhu, Fang Kong, Sisi Shan, Jiawei Zhao, Nan Wang, Xiaoou Sun, Linqi Zhang, Chuangye Yan, Brian K. Kobilka, Xiangyu Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The α1A-adrenergic receptor (α1AAR) belongs to the family of G protein-coupled receptors that respond to adrenaline and noradrenaline. α1AAR is involved in smooth muscle contraction and cognitive function. Here, we present three cryo-elec
Externí odkaz:
https://doaj.org/article/50bdf748659847fea35e92cceaacec7d
Autor:
Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J. Clark, Anne Stößel, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A. J. Venkatakrishnan, Ron O. Dror, Brian K. Kobilka, Roger K. Sunahara, Xiangyu Liu, Peter Gmeiner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract G protein-coupled receptors (GPCRs) within the same subfamily often share high homology in their orthosteric pocket and therefore pose challenges to drug development. The amino acids that form the orthosteric binding pocket for epinephrine a
Externí odkaz:
https://doaj.org/article/06de6af761474c2b9a90d90838043ba7
Autor:
Jie Heng, Yunfei Hu, Guillermo Pérez-Hernández, Asuka Inoue, Jiawei Zhao, Xiuyan Ma, Xiaoou Sun, Kouki Kawakami, Tatsuya Ikuta, Jienv Ding, Yujie Yang, Lujia Zhang, Sijia Peng, Xiaogang Niu, Hongwei Li, Ramon Guixà-González, Changwen Jin, Peter W. Hildebrand, Chunlai Chen, Brian K. Kobilka
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Advances in structural biology have provided important mechanistic insights into signaling by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is known about intrinsically disordered regions such as the carbo
Externí odkaz:
https://doaj.org/article/6adf05da047844e19288363de84f8e23
Autor:
Jun Xu, Qinggong Wang, Harald Hübner, Yunfei Hu, Xiaogang Niu, Haoqing Wang, Shoji Maeda, Asuka Inoue, Yuyong Tao, Peter Gmeiner, Yang Du, Changwen Jin, Brian K. Kobilka
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Here, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands.
Externí odkaz:
https://doaj.org/article/2a8a4fc6bad2451e913c4050e4dba574
Autor:
Bingfa Sun, Dan Feng, Matthew Ling-Hon Chu, Inbar Fish, Silvia Lovera, Zara A. Sands, Sebastian Kelm, Anne Valade, Martyn Wood, Tom Ceska, Tong Sun Kobilka, Florence Lebon, Brian K. Kobilka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Recently, a class of non-catechol Dopamine D1 receptor (D1R) selective agonists with novel scaffold and improved pharmacological properties were reported. Here, authors report the crystal structure of D1R in complex with stimulatory G protein (Gs) an
Externí odkaz:
https://doaj.org/article/2dbb4259799647b08364c62567b2949b
Autor:
Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J. Clark, Anne Stößel, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A. J. Venkatakrishnan, Ron O. Dror, Brian K. Kobilka, Roger K. Sunahara, Xiangyu Liu, Peter Gmeiner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a33640b5b5bf4ee68a4f3543dfc0d68f
Autor:
Alpay Burak Seven, Daniel Hilger, Makaía M. Papasergi-Scott, Li Zhang, Qianhui Qu, Brian K. Kobilka, Gregory G. Tall, Georgios Skiniotis
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3699-3709.e6 (2020)
Summary: Many chaperones promote nascent polypeptide folding followed by substrate release through ATP-dependent conformational changes. Here we show cryoEM structures of Gα subunit folding intermediates in complex with full-length Ric-8A, a unique
Externí odkaz:
https://doaj.org/article/17f4656dd6a64188bc8fbddf98884eac
Autor:
Shoji Maeda, Antoine Koehl, Hugues Matile, Hongli Hu, Daniel Hilger, Gebhard F. X. Schertler, Aashish Manglik, Georgios Skiniotis, Roger J. P. Dawson, Brian K. Kobilka
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The determination of high resolution structures of G protein coupled receptors (GPCRs) in complex with heterotrimeric G proteins is challenging. Here authors develop an antibody fragment, mAB16, which stabilizes GPCR/G-protein complexes and facilitat
Externí odkaz:
https://doaj.org/article/78767849a46d4536a969df36dd817784
Autor:
Qianhui Qu, Weijiao Huang, Deniz Aydin, Joseph M. Paggi, Alpay B. Seven, Haoqing Wang, Soumen Chakraborty, Tao Che, Jeffrey F. DiBerto, Michael J. Robertson, Asuka Inoue, Carl-Mikael Suomivuori, Bryan L. Roth, Susruta Majumdar, Ron O. Dror, Brian K. Kobilka, Georgios Skiniotis
Publikováno v:
Nature Chemical Biology. 19:423-430
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7359c5cc984e9bb96ea9d0131a946064
https://doi.org/10.1038/s41589-022-01208-y
https://doi.org/10.1038/s41589-022-01208-y
Autor:
Hazrat Hussain, Jonas S. Mortensen, Yang Du, Claudia Santillan, Orquidea Ribeiro, Juyeon Go, Parameswaran Hariharan, Claus J. Loland, Lan Guan, Brian K. Kobilka, Bernadette Byrne, Pil Seok Chae
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract High-resolution membrane protein structures are essential for understanding the molecular basis of diverse biological events and important in drug development. Detergents are usually used to extract these bio-macromolecules from the membrane
Externí odkaz:
https://doaj.org/article/087002c5c6c2415c9ebf4a39ab6e0c4d