Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Brian K, Hubbard"'
Autor:
Seongah Han, Taro E. Akiyama, Stephen F. Previs, Kithsiri Herath, Thomas P. Roddy, Kristian K. Jensen, Hong-Ping Guan, Beth A. Murphy, Lesley A. McNamara, Xun Shen, Walter Strapps, Brian K. Hubbard, Shirly Pinto, Cai Li, Jing Li
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2615-2622 (2013)
Hepatic glucose overproduction is a major characteristic of type 2 diabetes. Because glucagon is a key regulator for glucose homeostasis, antagonizing the glucagon receptor (GCGR) is a possible therapeutic strategy for the treatment of diabetes melli
Externí odkaz:
https://doaj.org/article/1d1d5798fd99409895b2d79ffd6971d0
Autor:
Haihong Zhou, Wenyu Li, Sheng-Ping Wang, Vivienne Mendoza, Raymond Rosa, James Hubert, Kithsiri Herath, Theresa McLaughlin, Rory J. Rohm, Michael E. Lassman, Kenny K. Wong, Douglas G. Johns, Stephen F. Previs, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1223-1231 (2012)
Stable isotope tracer studies of apoprotein flux in rodent models present difficulties as they require working with small volumes of plasma. We demonstrate the ability to measure apoprotein flux by administering either 2H- or 18O-labeled water to mic
Externí odkaz:
https://doaj.org/article/6c63ed70b4314113b68773d0b93c3352
Autor:
Wu Yin, Ester Carballo-Jane, David G. McLaren, Vivienne H. Mendoza, Karen Gagen, Neil S. Geoghagen, Lesley Ann McNamara, Judith N. Gorski, George J. Eiermann, Aleksandr Petrov, Michael Wolff, Xinchun Tong, Larissa C. Wilsie, Taro E. Akiyama, Jing Chen, Anil Thankappan, Jiyan Xue, Xiaoli Ping, Genevieve Andrews, L. Alexandra Wickham, Cesaire L. Gai, Tu Trinh, Alison A. Kulick, Marcie J. Donnelly, Gregory O. Voronin, Ray Rosa, Anne-Marie Cumiskey, Kavitha Bekkari, Lyndon J. Mitnaul, Oscar Puig, Fabian Chen, Richard Raubertas, Peggy H. Wong, Barbara C. Hansen, Ken S. Koblan, Thomas P. Roddy, Brian K Hubbard, Alison M. Strack
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 1, Pp 51-65 (2012)
In an attempt to understand the applicability of various animal models to dyslipidemia in humans and to identify improved preclinical models for target discovery and validation for dyslipidemia, we measured comprehensive plasma lipid profiles in 24 m
Externí odkaz:
https://doaj.org/article/6f89390063644b94adcc91712857c997
Autor:
Jose Castro-Perez, François Briand, Karen Gagen, Sheng-Ping Wang, Ying Chen, David G. McLaren, Vinit Shah, Rob J. Vreeken, Thomas Hankemeier, Thierry Sulpice, Thomas P. Roddy, Brian K. Hubbard, Douglas G. Johns
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 1965-1973 (2011)
Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester (CE) and triglyceride between HDL and apoB-containing lipoproteins. Anacetrapib (ANA), a reversible inhibitor of CETP, raises HDL cholesterol (HDL-C) and lowers LDL cholesterol in
Externí odkaz:
https://doaj.org/article/83541afcd8634ff88cfe29d2ff63b5d4
Autor:
Stephen F. Previs, Ablatt Mahsut, Alison Kulick, Keiana Dunn, Genevieve Andrews-Kelly, Christopher Johnson, Gowri Bhat, Kithsiri Herath, Paul L. Miller, Sheng-Ping Wang, Karim Azer, Jing Xu, Douglas G. Johns, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 7, Pp 1420-1428 (2011)
The advantages of using 2H2O to quantify cholesterol synthesis include i) homogeneous precursor labeling, ii) incorporation of 2H via multiple pathways, and iii) the ability to perform long-term studies in free-living subjects. However, there are two
Externí odkaz:
https://doaj.org/article/ff2afdbb781d47b6b23bed7e3352c5b1
Autor:
David G. McLaren, Timothy He, Sheng-Ping Wang, Vivienne Mendoza, Raymond Rosa, Karen Gagen, Gowri Bhat, Kithsiri Herath, Paul L. Miller, Sloan Stribling, Andrew Taggart, Jason Imbriglio, Jinqi Liu, Dunlu Chen, Shirly Pinto, James M. Balkovec, Robert J. DeVita, Donald J. Marsh, Jose M. Castro-Perez, Alison Strack, Douglas G. Johns, Stephen F. Previs, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 6, Pp 1150-1161 (2011)
The use of stable isotopically labeled substrates and analysis by mass spectrometry have provided substantial insight into rates of synthesis, disposition, and utilization of lipids in vivo. The information to be gained from such studies is of partic
Externí odkaz:
https://doaj.org/article/d66b12300bbf4a1f976747589c656716
Autor:
Marija Tadin-Strapps, Laurence B. Peterson, Anne-Marie Cumiskey, Raymond L. Rosa, Vivienne Halili Mendoza, Jose Castro-Perez, Oscar Puig, Liwen Zhang, Walter R. Strapps, Satyasri Yendluri, Lori Andrews, Victoria Pickering, Julie Rice, Lily Luo, Zhu Chen, Samnang Tep, Brandon Ason, Elizabeth Polizzi Somers, Alan B. Sachs, Steven R. Bartz, Jenny Tian, Jayne Chin, Brian K. Hubbard, Kenny K. Wong, Lyndon J. Mitnaul
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 6, Pp 1084-1097 (2011)
Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE–/– and low density lipoprotein receptor (LDLr)–/– mice have been extensively used for studies of coronary ath
Externí odkaz:
https://doaj.org/article/0b029968df064a1196d6bf73ea9f6a26
Autor:
Jose Castro-Perez, Stephen F. Previs, David G. McLaren, Vinit Shah, Kithsiri Herath, Gowri Bhat, Douglas G. Johns, Sheng-Ping Wang, Lyndon Mitnaul, Kristian Jensen, Robert Vreeken, Thomas Hankemeier, Thomas P. Roddy, Brian K. Hubbard
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 1, Pp 159-169 (2011)
High resolution LC/MS-MS and LC/APPI-MS methods have been established for the quantitation of flux in the turnover of cholesterol and cholesterol ester. Attention was directed toward quantifying the monoisotopic mass (M0) and that of the singly deute
Externí odkaz:
https://doaj.org/article/c748fc80dd984745b02810b15b8a171d
Autor:
Mali Liu, Guoxin Wu, Jennifer Baysarowich, Michael Kavana, George H. Addona, Kathleen K. Bierilo, John S. Mudgett, Guillaume Pavlovic, Ayesha Sitlani, John J. Renger, Brian K. Hubbard, Timothy S. Fisher, Celina V. Zerbinatti
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2611-2618 (2010)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates hepatic low-density lipoprotein receptor (LDLR) levels in humans. PCSK9 has also been shown to regulate the levels of additional membrane-bound proteins in vit
Externí odkaz:
https://doaj.org/article/4c28810f0e7f4bedb9bdad0182e74028
Autor:
Matthew C Clifton, David M Dranow, Alison Leed, Ben Fulroth, James W Fairman, Jan Abendroth, Kateri A Atkins, Ellen Wallace, Dazhong Fan, Guoping Xu, Z J Ni, Doug Daniels, John Van Drie, Guo Wei, Alex B Burgin, Todd R Golub, Brian K Hubbard, Michael H Serrano-Wu
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125010 (2015)
Crystallization of a maltose-binding protein MCL1 fusion has yielded a robust crystallography platform that generated the first apo MCL1 crystal structure, as well as five ligand-bound structures. The ability to obtain fragment-bound structures advan
Externí odkaz:
https://doaj.org/article/1fecc03a2b9c44169e845be5165ab56e