Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Brian Jow"'
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Functional Properties of α7 Nicotinic Acetylcholine Receptors Co-expressed with RIC-3 in a Stable Recombinant CHO-K1 Cell Line
Autor: Renza Roncarati, Silvia Papini, John Dunlop, Georg C. Terstappen, Brian Jow, Tamara Seredenina, Hendrick Bothmann, Angela Kramer, Flora Jow
Publikováno v: ASSAY and Drug Development Technologies. 6:181-193
Heterologous functional expression of alpha7 nicotinic acetylcholine receptors (nAChRs) is difficult to achieve in mammalian cell lines, and the reasons have been associated with a lack of expression of the putative chaperone factor RIC-3. Here, we d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc951e024b080c0431884d00c461f7a
https://doi.org/10.1089/adt.2007.120
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3
In vitro screening strategies for nicotinic receptor ligands
Autor: John Dunlop, Hendrick Bothmann, Brian Jow, Mark R. Bowlby, Dianne Kowal, Georg C. Terstappen, Tim Lock, Renza Roncarati
Publikováno v: Biochemical Pharmacology. 74:1172-1181
A common historical strategy to the discovery of nicotinic receptor ligands has involved the use of radioligand-binding assays for ligand identification in combination with two-electrode voltage clamp in Xenopus oocytes for electrophysiological chara
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c77463e4c033ae0a5842ee26a1b8577
https://doi.org/10.1016/j.bcp.2007.07.006
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4
Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2
Autor: Alexander Greenfield, Tikva Carrick, John A. Butera, Dianne Kowal, John Dunlop, Brian Jow, Cristina Grosanu, Qiang Lu, Beal McIlvain, John P. Williams
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:4985-4988
Excitatory amino acid transporters (EAATs) play a pivotal role in maintaining glutamate homeostasis in the mammalian central nervous system, with the EAAT-2 subtype thought to be responsible for the bulk of the glutamate uptake in forebrain regions.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5a1dd7bbb3e90347e18220f7cf664f
https://doi.org/10.1016/j.bmcl.2005.08.003
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5
The effects of ZD6169 on the ATP-dependent K+ current (IKATP) in isolated cat ventricular myocytes
Autor: Randy Numann, Brian Jow
Publikováno v: European Journal of Pharmacology. 383:197-202
The effect of the K(ATP) channel opener ZD6169 [(S)-N-(4-benzoyl-phenyl)-3,3, 3-trifluoro-2-hydroxy-2-methyl-propionamide] currently under development for the treatment of urinary incontinence was explored in acutely isolated adult feline ventricular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8e6c11dcd6f580460d61312013e0dd
https://doi.org/10.1016/s0014-2999(99)00630-5
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6
Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders
Autor: Georg C. Terstappen, Thomas A. Comery, Suzan Aschmi, Hendrick Bothmann, Carla Scali, Renza Roncarati, Steven M. Grauer, Brian Jow, Dianne Kowal, Ugo Zanelli, Marco Gianfriddo, Chiara Ghiron, Cody Kelley, John Dunlop, Simon Haydar
Publikováno v: The Journal of pharmacology and experimental therapeutics. 329(2)
The alpha7 nicotinic acetylcholine receptor (nAChR) is a promising target for treatment of cognitive dysfunction associated with Alzheimer's disease and schizophrenia. Here, we report the pharmacological properties of 5-morpholin-4-yl-pentanoic acid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbb0cce09cce33e00f4f1415b25eb68
https://pubmed.ncbi.nlm.nih.gov/19223665
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9
Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2
Autor: Dianne Kowal, Cristina Grosanu, Stephen Lin, Robert E. Petroski, Brian Jow, John Dunlop, John A. Butera, Tikva Carrick, Alexander Greenfield, Alan C. Foster, John A. Williams, Beal McIlvain, Kristi Fan, Qiang Lu
Publikováno v: Molecular pharmacology. 68(4)
In this study, we describe the pharmacological characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of EAAT2, the predominant glutamate transporter in forebrain regions. The r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620dcbabe015ca0a8a07c8907e673c38
https://pubmed.ncbi.nlm.nih.gov/16014807
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10
Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: block of delayed rectifier potassium and L-type calcium currents
Autor: Joseph J. Lynch, Brian Jow, Nancy K. Jurkiewicz, Bernard Fermini, Elizabeth P. Baskin, Peter J. Guinosso, Joseph J. Salata
Publikováno v: Journal of cardiovascular pharmacology. 26(2)
We studied the effects of NE-10064 (azimilide), a new antiarrhythmic agent reported to be a selective blocker of the slowly activating component of the delayed rectifier, IKs. In ferret papillary muscles, NE-10064 increased effective refractory perio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a565a742fb7279d23156cbb8296f8928
https://pubmed.ncbi.nlm.nih.gov/7475051
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