Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Brian John Williams"'
Autor:
Tess Cramond, L. Gorta, A. W. Gordon Macleod, M. Voltz, Bruce Ashford, Judy M. Simpson, Brian John Williams
Publikováno v:
Australian Dental Journal. 47:147-151
Background: Codeine is frequently added to paracetamol to treat post-operative dento-alveolar pain; studies have shown effectiveness in relief of post-operative pain at high doses but at the expense of central nervous and gastrointestinal side effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d052707f70c1676488f0287e75a2b65
https://doi.org/10.1111/j.1834-7819.2002.tb00319.x
https://doi.org/10.1111/j.1834-7819.2002.tb00319.x
Autor:
Ruth O'Donnell, Raymond G. Hill, James G. Bilsland, Christopher John Swain, Smith David W, Desmond O'Connor, Sarah J. Harper, Michael Rigby, Susan Boyce, Franz Hefti, D Evans, Louise Hewson, L Young, G Mason, L. Bristow, Brian John Williams
Publikováno v:
Neuroscience. 88:257-267
The putative neurotrophic effects of the immunophilin ligand GPI-1046 were evaluated in established experimental systems of neuron survival and axon growth in vitro and in vivo. GPI-1046 marginally increased neurite outgrowth of chick dorsal root gan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fb7c2a4b1596bec84e7723b4ef9abd
https://doi.org/10.1016/s0306-4522(98)00221-8
https://doi.org/10.1016/s0306-4522(98)00221-8
Autor:
Joe Metzger, Gary G. Chicchi, Linda Elizabeth Keown, R. Baker, Margaret A. Cascieri, Simon C. Morton, Christopher John Swain, A. P. Watt, Silvi Luell, Sharon Sadowski, Andrew Pate Owens, D. E. Macintyre, Michael J. Forrest, Richard H. Herbert, Brian John Williams, T. Ladduwahetty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2959-2962
In vitro metabolism studies on a series of 3,5-bis(trifluoromethyl)benzyl ethers have identified 3,5-bis(trifluoromethyl)benzoic acid as a significant metabolite possibly arising via oxidation of the benzylic position. A methyl group was introduced i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c91d24dae20b6ff7e21ea601fc6aac48
https://doi.org/10.1016/s0960-894x(97)10118-4
https://doi.org/10.1016/s0960-894x(97)10118-4
Autor:
R. Baker, Brian John Williams, T. Harrison, Christopher John Swain, Sharon Sadowski, Margaret A. Cascieri, Peter H. Hutson, Andrew Pate Owens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:209-212
The effect of nitrogen substitution on the binding affinity of the piperidine-ether substance P antagonist L-733,060 for the hNK 1 receptor and L-type Ca 2+ channel is discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::266a2d44c9dc653b4cf0c9bde484de35
https://doi.org/10.1016/0960-894x(95)00009-i
https://doi.org/10.1016/0960-894x(95)00009-i
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2545-2550
The synthesis of a new series of piperidine-based ethers is described and the relative and absolute stereochemical requirements necessary for high affinity binding to the hNK1 receptor established. The synthesis of the corresponding pyrrolidine deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0cc6e27fea39b0516204910ea43cc6e
https://doi.org/10.1016/s0960-894x(01)80280-8
https://doi.org/10.1016/s0960-894x(01)80280-8
Autor:
L. Singh, Linda J. Bristow, Paul D. Leeson, Brian John Williams, Peter H. Hutson, Mark D. Tricklebank, F. D. Tattersall, Michael Rowley, L. Thorn, K. L. Saywell
Publikováno v:
British Journal of Pharmacology. 113:729-736
1. The anticonvulsant and behavioural effects of the glycine/NMDA receptor partial agonist, L-687,414 (R(+)-cis-beta-methyl-3-amino-1-hydroxypyrrolid-2-one) have been investigated in rodents. 2. L-687,414 dose-dependently antagonized seizures induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0008ac0b50d7ca3fca8462b14ada314
https://doi.org/10.1111/j.1476-5381.1994.tb17054.x
https://doi.org/10.1111/j.1476-5381.1994.tb17054.x
Autor:
Andrew Pate Owens, Christopher John Swain, Sharon Sadowski, M. B. Van Niel, Brian John Williams, Walfred S. Saari, Catherine D. Strader, Martin Richard Teall, Margaret A. Cascieri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2161-2164
An exploration of benzhydryl replacements is described. Whilst bridged and fused polynuclear aromatic systems both incur a reduction in affinity it was possible to replace the benzhydryl by a single phenyl ring with only a modest reduction in affinit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abb5496b5259c169168b42ebe620e6c0
https://doi.org/10.1016/s0960-894x(00)80063-3
https://doi.org/10.1016/s0960-894x(00)80063-3
Autor:
Catherine D. Strader, Timothy Harrison, Martin Richard Teall, Margaret A. Cascieri, Christopher John Swain, Sharon Sadowski, Raymond Baker, Jeffrey Mc Kenna, Brian John Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1903-1908
A series of 2-aminoethyl ethers based on diphenylalaninol have been shown to have significant affinity for the human NK 1 receptor and reduced affinity at the L-type Ca ++ channel compared with quinuclidines related to CP 96,345.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af67d24e0890a55cbab212571c1b0a14
https://doi.org/10.1016/s0960-894x(01)80531-x
https://doi.org/10.1016/s0960-894x(01)80531-x
Autor:
A E Donald, Alan C. Foster, Michael Rowley, Raymond Baker, Kevin W. Moore, Tony Priestley, John A. Kemp, Brian John Williams, Paul D. Leeson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:71-76
The in vitro activies of 4-substituted and bicyclic analogues of the glycine-site NMDA partial agonist HA-966 (1) reveal strict structure-activity requirements reflecting subtle conformational and steric requirements for receptor binding. The most ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a478e45e83c868b73b116d21e650b08
https://doi.org/10.1016/s0960-894x(00)80094-3
https://doi.org/10.1016/s0960-894x(00)80094-3
Autor:
Janet J. Maguire, Raymond Baker, Stephen Young, Brian John Williams, Daniel F. Veber, Neil Roy Curtis, Alexander T. McKnight
Publikováno v:
Journal of Medicinal Chemistry. 36:2-10
Twenty homodetic cyclic peptides based on the C-terminal sequence of substance P were prepared (Table I) by a combination of solid-phase techniques and cyclizations using azide coupling procedures. Incorporation of dipeptide mimics based on substitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae5390c2a27c5887f4f7513db4c5ac2
https://doi.org/10.1021/jm00053a001
https://doi.org/10.1021/jm00053a001