Výsledky vyhledávání - "Brian Janelsins"

Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity (MUC4P.825)

Autor: Brian Janelsins, Sandip Datta

Publikováno v: The Journal of Immunology. 192:133.1-133.1

Interleukin 17 (IL-17)-secreting CD4+ helper T (Th17) cells are essential for host defense at mucosal surfaces, and dysregulation can result in autoimmunity. Exposure to microbial products such as lipopolysaccharide (LPS) can affect the ability of de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a75951db87a654c7a275ccbec3379253
https://doi.org/10.4049/jimmunol.192.supp.133.1

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The lard legacy: parental dietary fat intake alters offspring microbiome and immunity (P3359)

Autor: Ian Myles, Natalia Fontecella, Brian Janelsins, Paul Vithayathil, Julia Segre, Sandip Datta

Publikováno v: The Journal of Immunology. 190:202.2-202.2

Mechanisms underlying modern increases in prevalence of human inflammatory diseases remain unclear. The hygiene hypothesis postulates that decreased microbial exposure has, at least in part, driven this immune dysregulation. However, dietary fatty ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8dad090bcbfc5dea196e6ed060cc949f
https://doi.org/10.4049/jimmunol.190.supp.202.2

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Persistent exposure to endogenous LPS programs colonic lamina propria dendritic cells to impair CD4+ Th17 immunity in vivo (P3225)

Autor: Brian Janelsins, Patricia Valdez, Robert Munford, Mingfang Lu, Sandip Datta

Publikováno v: The Journal of Immunology. 190:171.25-171.25

Gram-negative bacteria drive CD4+ T helper type-17 (Th17) immunity via lipopolysaccharide (LPS) activation of Toll-like receptor (TLR)4. However, excessive TLR4 stimulation can lead to a period of LPS tolerance, during which antigen-presenting cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b22a8991e62b708381a5757d10e81553
https://doi.org/10.4049/jimmunol.190.supp.171.25

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Neurokinin-1 receptor stimulated dendritic cell vaccines downregulate IL-10 and license host inflammatory dendritic cells to bias Th1 immunity (P4236)

Autor: Tina Sumpter, Brian Janelsins, Darling Rojas-Canales, Olga Tkacheva, William Shufesky, Adrian Morelli, Adriana Larregina

Publikováno v: The Journal of Immunology. 190:47.6-47.6

Substance-P (SP) is a neuropeptide that stimulates immunity by binding to the neurokinin-1 receptor (NK1R). As professional Ag presenting cells, dendritic cells (DC) are unique activators of naïve T cells. DC express functional NK1R, indicating tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5d7dadeca642e37f1ee2723bc105ff9
https://doi.org/10.4049/jimmunol.190.supp.47.6

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Signaling via neurokinin-1 receptor abrogates CREB translocation and of IL-10 secretion in myeloid dendritic cells resulting in potent Th1 and Tc1 biasing function (147.6)

Autor: Adriana Larregina, Brian Janelsins, Tina Sumpter, Alicia Mathers, Olga Tkacheva, Adrian Morelli

Publikováno v: The Journal of Immunology. 186:147.6-147.6

Neuropeptides regulate innate and adaptive immunity and immune cells express neuropeptide receptors like the pro-inflammatory neurokinin-1 receptor (NK1R). NK1R agonists favor cellular immunity. Myeloid dendritic cells (DC) that link innate and adapt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c0f82b9f5b6218dcdba6ffb76b81351
https://doi.org/10.4049/jimmunol.186.supp.147.6

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Administration of dendritic cells signaled via the neurokinin 1 receptor favors type-1 cellular immunity by mechanisms involving exogenous and endogenous dendritic cell populations (98.12)

Autor: Brian Janelsins, Alicia Mathers, Olga Tkacheva, Geza Erdos, William Shufesky, Adrian Morelli, Adriana Larregina

Publikováno v: The Journal of Immunology. 184:98.12-98.12

Induction of type-1 immunity is the focus of current dendritic cell (DC)-vaccination approaches for tumors and intracellular infections. The pro-inflammatory neuropeptides, substance P and hemokinin-1, favor cell-mediated immunity by binding the neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0898b71c3c3885ae928faaed6e062a5
https://doi.org/10.4049/jimmunol.184.supp.98.12

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Anti-melanoma immunity promoted by cutaneous genetic immunizations requires agonistic signaling via the nerokinin-1 receptor (131.6)

Autor: Alicia Mathers, Olga Tkacheva, Brian Janelsins, William Schufeski, Adrian Morelli, Adriana Larregina

Publikováno v: The Journal of Immunology. 184:131.6-131.6

In spite of initial enthusiasm provided by melanoma immunizations, the incidence of melanoma has increased in the past decade. To improve current melanoma vaccines is imperative that we understand the mechanisms involved in effective immunity to self

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17dfcf49f8c98db284a7487ceef475ff
https://doi.org/10.4049/jimmunol.184.supp.131.6

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Human skin migratory dendritic cells that do not secrete IL-12p70 stimulate both Th17 and Th1 allogeneic responses (36.20)

Autor: Alicia R Mathers, Adrian E Morelli, Brian Janelsins, Joseph P Rubin, Olga A Tkacheva, Louis D Falo, Adriana T Larregina

Publikováno v: The Journal of Immunology. 178:S16-S16

We analyzed the ability of human skin migratory dendritic cells (smiDC) to stimulate allogeneic (allo)-CD4+ T helper cell responses and to induce differentiation of Th1 and Th17 cells. SmiDCs obtained from cultures of human skin explants consisted of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::521fb4c25a6069b873aa8745d811e6b7
https://doi.org/10.4049/jimmunol.178.supp.36.20

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Genetic immunizations in the presence of a specific neurokinin 1 receptor agonist triggers Th1-Tc1 biased immune responses that protect against B16 melanomas (48.13)

Autor: Alicia R Mathers, Olga A Tkacheva, Brian Janelsins, William Schuffeski, Adrian E Morelli, Adriana T Larregina

Publikováno v: The Journal of Immunology. 178:S77-S77

Antigen (Ag) specific Th1-Tc1 cellular immunity induced by genetic immunizations is critical to prevent / eradicate tumors. The high number of resident dendritic cells (DCs) makes the skin an ideal microenvironment for genetic immunizations against t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f16ccc9bc2eb7400643c500da83ed32
https://doi.org/10.4049/jimmunol.178.supp.48.13

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