Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Brian Janelsins"'
Autor:
Melanie Royce, Christy L. Osgood, Anup K. Amatya, Mallorie H. Fiero, C.J. George Chang, Tiffany K. Ricks, Krithika A. Shetty, Jeffrey Kraft, Junshan Qiu, Pengfei Song, Rosane Charlab, Jingyu Yu, Kathryn E. King, Anshu Rastogi, Brian Janelsins, Wendy C. Weinberg, Kathleen Clouse, Vicky Borders-Hemphill, Lindsey Brown, Candace Gomez-Broughton, Zhong Li, Thuy Thanh Nguyen, Zhihao Qiu, Anh-Thy Ly, Suyoung Chang, Tingting Gao, Chi-Ming Tu, Bellinda King-Kallimanis, William F. Pierce, Kelly Chiang, Clara Lee, Kirsten B. Goldberg, John K. Leighton, Shenghui Tang, Richard Pazdur, Julia A. Beaver, Laleh Amiri-Kordestani
Publikováno v:
Clin Cancer Res
On December 16, 2020, the FDA granted regular approval to margetuximab-cmkb (MARGENZA), in combination with chemotherapy, for the treatment of adult patients with HER2-positive (HER2+) metastatic breast cancer who have received two or more prior anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa8e9dee50fa91f3a207a062eb0bc7e
https://doi.org/10.1158/1078-0432.ccr-21-3247
https://doi.org/10.1158/1078-0432.ccr-21-3247
Autor:
Brian Janelsins, Sandip Datta
Publikováno v:
The Journal of Immunology. 192:133.1-133.1
Interleukin 17 (IL-17)-secreting CD4+ helper T (Th17) cells are essential for host defense at mucosal surfaces, and dysregulation can result in autoimmunity. Exposure to microbial products such as lipopolysaccharide (LPS) can affect the ability of de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a75951db87a654c7a275ccbec3379253
https://doi.org/10.4049/jimmunol.192.supp.133.1
https://doi.org/10.4049/jimmunol.192.supp.133.1
Publikováno v:
The Journal of Immunology. 190:202.2-202.2
Mechanisms underlying modern increases in prevalence of human inflammatory diseases remain unclear. The hygiene hypothesis postulates that decreased microbial exposure has, at least in part, driven this immune dysregulation. However, dietary fatty ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dad090bcbfc5dea196e6ed060cc949f
https://doi.org/10.4049/jimmunol.190.supp.202.2
https://doi.org/10.4049/jimmunol.190.supp.202.2
Publikováno v:
The Journal of Immunology. 190:171.25-171.25
Gram-negative bacteria drive CD4+ T helper type-17 (Th17) immunity via lipopolysaccharide (LPS) activation of Toll-like receptor (TLR)4. However, excessive TLR4 stimulation can lead to a period of LPS tolerance, during which antigen-presenting cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22a8991e62b708381a5757d10e81553
https://doi.org/10.4049/jimmunol.190.supp.171.25
https://doi.org/10.4049/jimmunol.190.supp.171.25
Autor:
Tina Sumpter, Brian Janelsins, Darling Rojas-Canales, Olga Tkacheva, William Shufesky, Adrian Morelli, Adriana Larregina
Publikováno v:
The Journal of Immunology. 190:47.6-47.6
Substance-P (SP) is a neuropeptide that stimulates immunity by binding to the neurokinin-1 receptor (NK1R). As professional Ag presenting cells, dendritic cells (DC) are unique activators of naïve T cells. DC express functional NK1R, indicating tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5d7dadeca642e37f1ee2723bc105ff9
https://doi.org/10.4049/jimmunol.190.supp.47.6
https://doi.org/10.4049/jimmunol.190.supp.47.6
Autor:
Adriana Larregina, Brian Janelsins, Tina Sumpter, Alicia Mathers, Olga Tkacheva, Adrian Morelli
Publikováno v:
The Journal of Immunology. 186:147.6-147.6
Neuropeptides regulate innate and adaptive immunity and immune cells express neuropeptide receptors like the pro-inflammatory neurokinin-1 receptor (NK1R). NK1R agonists favor cellular immunity. Myeloid dendritic cells (DC) that link innate and adapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c0f82b9f5b6218dcdba6ffb76b81351
https://doi.org/10.4049/jimmunol.186.supp.147.6
https://doi.org/10.4049/jimmunol.186.supp.147.6
Autor:
Brian Janelsins, Alicia Mathers, Olga Tkacheva, Geza Erdos, William Shufesky, Adrian Morelli, Adriana Larregina
Publikováno v:
The Journal of Immunology. 184:98.12-98.12
Induction of type-1 immunity is the focus of current dendritic cell (DC)-vaccination approaches for tumors and intracellular infections. The pro-inflammatory neuropeptides, substance P and hemokinin-1, favor cell-mediated immunity by binding the neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0898b71c3c3885ae928faaed6e062a5
https://doi.org/10.4049/jimmunol.184.supp.98.12
https://doi.org/10.4049/jimmunol.184.supp.98.12
Autor:
Alicia Mathers, Olga Tkacheva, Brian Janelsins, William Schufeski, Adrian Morelli, Adriana Larregina
Publikováno v:
The Journal of Immunology. 184:131.6-131.6
In spite of initial enthusiasm provided by melanoma immunizations, the incidence of melanoma has increased in the past decade. To improve current melanoma vaccines is imperative that we understand the mechanisms involved in effective immunity to self
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17dfcf49f8c98db284a7487ceef475ff
https://doi.org/10.4049/jimmunol.184.supp.131.6
https://doi.org/10.4049/jimmunol.184.supp.131.6
Autor:
Alicia R Mathers, Adrian E Morelli, Brian Janelsins, Joseph P Rubin, Olga A Tkacheva, Louis D Falo, Adriana T Larregina
Publikováno v:
The Journal of Immunology. 178:S16-S16
We analyzed the ability of human skin migratory dendritic cells (smiDC) to stimulate allogeneic (allo)-CD4+ T helper cell responses and to induce differentiation of Th1 and Th17 cells. SmiDCs obtained from cultures of human skin explants consisted of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::521fb4c25a6069b873aa8745d811e6b7
https://doi.org/10.4049/jimmunol.178.supp.36.20
https://doi.org/10.4049/jimmunol.178.supp.36.20
Autor:
Alicia R Mathers, Olga A Tkacheva, Brian Janelsins, William Schuffeski, Adrian E Morelli, Adriana T Larregina
Publikováno v:
The Journal of Immunology. 178:S77-S77
Antigen (Ag) specific Th1-Tc1 cellular immunity induced by genetic immunizations is critical to prevent / eradicate tumors. The high number of resident dendritic cells (DCs) makes the skin an ideal microenvironment for genetic immunizations against t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f16ccc9bc2eb7400643c500da83ed32
https://doi.org/10.4049/jimmunol.178.supp.48.13
https://doi.org/10.4049/jimmunol.178.supp.48.13