Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Brian J.P. Huntly"'
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105622- (2022)
Summary: Several studies have documented aberrant RNA editing patterns across multiple tumors across large patient cohorts from The Cancer Genome Atlas (TCGA). However, studies on understanding the role of RNA editing in acute myeloid leukemia (AML)
Externí odkaz:
https://doaj.org/article/0c7677ca02cc4eab950752ae31ce4cbc
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101770- (2022)
Summary: Recurrent gene mutations often cooperate in a predefined stepwise and synergistic manner to alter global transcription, through directly or indirectly remodeling epigenetic landscape on linear and three-dimensional (3D) scales. Here, we pres
Externí odkaz:
https://doaj.org/article/0d755c75cfb44d0181e7fd5ef22661e0
Autor:
Konstantinos Tzelepis, Hiroko Koike-Yusa, Etienne De Braekeleer, Yilong Li, Emmanouil Metzakopian, Oliver M. Dovey, Annalisa Mupo, Vera Grinkevich, Meng Li, Milena Mazan, Malgorzata Gozdecka, Shuhei Ohnishi, Jonathan Cooper, Miten Patel, Thomas McKerrell, Bin Chen, Ana Filipa Domingues, Paolo Gallipoli, Sarah Teichmann, Hannes Ponstingl, Ultan McDermott, Julio Saez-Rodriguez, Brian J.P. Huntly, Francesco Iorio, Cristina Pina, George S. Vassiliou, Kosuke Yusa
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1193-1205 (2016)
Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which mainstream treatments have not changed for decades. To identify additional therapeutic targets in AML, we optimize a genome-wide clustered regularly interspaced sho
Externí odkaz:
https://doaj.org/article/c8faecf711f04641b78d953688cead72
Autor:
Sarah J. Horton, Brian J.P. Huntly
Publikováno v:
Haematologica, Vol 97, Iss 7 (2012)
The existence of cancer stem cells has long been postulated, but was proven less than 20 years ago following the demonstration that only a small sub-fraction of leukemic cells from acute myeloid leukemia patients were able to propagate the disease in
Externí odkaz:
https://doaj.org/article/de3a5e95b1e446dcbeabde4ba2e731c7
Autor:
Michael Dickinson, Brandon E. Kremer, Arindam Dhar, Thierry Horner, Shawn W. Foley, Michael T. McCabe, Natalie O. Karpinich, Geraldine Ferron-Brady, Evi Bakirtzi, Olena Barbash, Anu Shilpa Krishnatry, Anastasia Wyce, Paolo Gallipoli, Ludovica Marando, Faisal Basheer, Regina García Delgado, Paul Yeh, Natalia Tovar, Maria-Victoria Mateos, Manali Kamdar, Jacob L. Glass, Gareth J. Morgan, Faith E. Davies, Daniel A. Pollyea, Dan T. Vogl, Aristeidis Chaidos, Adrian Alegre, Anastasios Karadimitris, Brian J.P. Huntly, Gautam Borthakur, Mark A. Dawson
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634832d4a4352226ded7a6d727fa619e
https://doi.org/10.1158/1078-0432.22490779
https://doi.org/10.1158/1078-0432.22490779
Autor:
Michael Dickinson, Brandon E. Kremer, Arindam Dhar, Thierry Horner, Shawn W. Foley, Michael T. McCabe, Natalie O. Karpinich, Geraldine Ferron-Brady, Evi Bakirtzi, Olena Barbash, Anu Shilpa Krishnatry, Anastasia Wyce, Paolo Gallipoli, Ludovica Marando, Faisal Basheer, Regina García Delgado, Paul Yeh, Natalia Tovar, Maria-Victoria Mateos, Manali Kamdar, Jacob L. Glass, Gareth J. Morgan, Faith E. Davies, Daniel A. Pollyea, Dan T. Vogl, Aristeidis Chaidos, Adrian Alegre, Anastasios Karadimitris, Brian J.P. Huntly, Gautam Borthakur, Mark A. Dawson
Purpose:Molibresib is a selective, small molecule inhibitor of the bromodomain and extra-terminal (BET) protein family. This was an open-label, two-part, Phase I/II study investigating molibresib monotherapy for the treatment of hematological maligna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b56a0a4932aa41df4a01b11e3217650
https://doi.org/10.1158/1078-0432.c.6533218.v1
https://doi.org/10.1158/1078-0432.c.6533218.v1
Autor:
Brian J.P. Huntly, D. Gary Gilliland, Hartmut Döhner, Scott A. Armstrong, Ruud Delwel, Peter J.M. Valk, Inusha De Silva, Benjamin H. Lee, Axel Benner, Rachel Okabe, Stanley E. Lazic, Donna Foster, Christopher Sears, Mukundhan Ramaswami, Lars Bullinger, Wai-In Chan, Brynn T. Kvinlaug
Supplementary Figure 1 from Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a3f1a16c4e7f6746cacc6ffa3b45f7
https://doi.org/10.1158/0008-5472.22388193.v1
https://doi.org/10.1158/0008-5472.22388193.v1
Autor:
Brian J.P. Huntly, D. Gary Gilliland, Hartmut Döhner, Scott A. Armstrong, Ruud Delwel, Peter J.M. Valk, Inusha De Silva, Benjamin H. Lee, Axel Benner, Rachel Okabe, Stanley E. Lazic, Donna Foster, Christopher Sears, Mukundhan Ramaswami, Lars Bullinger, Wai-In Chan, Brynn T. Kvinlaug
Supplementary Figure 3 from Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc57421bc889f4d323840f8e2f42c04
https://doi.org/10.1158/0008-5472.22388187
https://doi.org/10.1158/0008-5472.22388187
Autor:
Brian J.P. Huntly, D. Gary Gilliland, Hartmut Döhner, Scott A. Armstrong, Ruud Delwel, Peter J.M. Valk, Inusha De Silva, Benjamin H. Lee, Axel Benner, Rachel Okabe, Stanley E. Lazic, Donna Foster, Christopher Sears, Mukundhan Ramaswami, Lars Bullinger, Wai-In Chan, Brynn T. Kvinlaug
Supplementary Table 5 from Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f9ec19d2cc32e5891ed6ad1cbb86f2
https://doi.org/10.1158/0008-5472.22388178
https://doi.org/10.1158/0008-5472.22388178
Autor:
Brian J.P. Huntly, D. Gary Gilliland, Hartmut Döhner, Scott A. Armstrong, Ruud Delwel, Peter J.M. Valk, Inusha De Silva, Benjamin H. Lee, Axel Benner, Rachel Okabe, Stanley E. Lazic, Donna Foster, Christopher Sears, Mukundhan Ramaswami, Lars Bullinger, Wai-In Chan, Brynn T. Kvinlaug
Supplementary Table 7 from Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b2b748bc8be5525470e86768faac2c
https://doi.org/10.1158/0008-5472.22388172.v1
https://doi.org/10.1158/0008-5472.22388172.v1