Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Brian J. Ward"'
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTDeveloping a vaccine against Clostridioides difficile is a key strategy to protect the elderly. Two candidate vaccines using a traditional approach of intramuscular (IM) delivery of recombinant antigens targeting C. difficile toxins A (TcdA)
Externí odkaz:
https://doaj.org/article/337cd304d061401a9605cc8fdcdcf132
Autor:
Adam S. Hassan, Sébastien Houle, Lydia Labrie, Dilhan J. Perera, Charles M. Dozois, Brian J. Ward, Momar Ndao
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Schistosomiasis threatens hundreds of millions of people worldwide. The larval stage of Schistosoma mansoni migrates through the lung and adult worms reside adjacent to the colonic mucosa. Several candidate vaccines are in preclinical develo
Externí odkaz:
https://doaj.org/article/1d8b8422848d43278bc501a2221fbf5a
Autor:
Paulina Kaplonek, Deniz Cizmeci, Jessica Shih-Lu Lee, Sally A. Shin, Stephanie Fischinger, Philipe Gobeil, Stéphane Pillet, Nathalie Charland, Brian J. Ward, Galit Alter
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Despite the success of existing COVID-19 vaccine platforms, the persistent limitations in global deployment of vaccines and waning immunity exhibited by many of the currently deployed vaccine platforms have led to perpetual outbreaks of SARS
Externí odkaz:
https://doaj.org/article/d55dbfe42ce74d4cbb08ac3c06582bd4
Autor:
Nathalie Charland, Philipe Gobeil, Stéphane Pillet, Iohann Boulay, Annie Séguin, Alexander Makarkov, Gretchen Heizer, Kapil Bhutada, Asif Mahmood, Sonia Trépanier, Karen Hager, Julia Jiang-Wright, Judith Atkins, Pooja Saxena, Matthew P. Cheng, Donald C. Vinh, Philippe Boutet, François Roman, Robbert Van Der Most, Maria Angeles Ceregido, Marc Dionne, Guy Tellier, Jean-Sébastien Gauthier, Brandon Essink, Michael Libman, Jason Haffizulla, André Fréchette, Marc-André D’Aoust, Nathalie Landry, Brian J. Ward
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract The rapid spread of SARS-CoV-2 continues to impact humanity on a global scale with rising total morbidity and mortality. Despite the development of several effective vaccines, new products are needed to supply ongoing demand and to fight var
Externí odkaz:
https://doaj.org/article/b6a4cc5cfcb64d00803666e2639e3ffb
Autor:
Philipe Gobeil, Stéphane Pillet, Iohann Boulay, Nathalie Charland, Aurélien Lorin, Matthew P. Cheng, Donald C. Vinh, Philippe Boutet, Robbert Van Der Most, François Roman, Maria Angeles Ceregido, Nathalie Landry, Marc-André D’Aoust, Brian J. Ward
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Here, the authors report results from a Phase 1 trial with an AS03-adjuvanted, plant-based virus-like particle displaying the spike protein of the ancestral SARS-CoV-2. Six months post-second dose, they observe good neutralizing antibody titers and T
Externí odkaz:
https://doaj.org/article/5f0bb8c08c0147bdb05f3296700f7ce0
Autor:
Hilary E. Hendin, Pierre-Olivier Lavoie, Jason M. Gravett, Stéphane Pillet, Pooja Saxena, Nathalie Landry, Marc-André D’Aoust, Brian J. Ward
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract The binding of influenza hemagglutinin (HA) to sialic acid (SA) receptors plays a well-defined role in shaping infection but the impact of such binding on vaccine responses has not yet been explored. We generated a virus-like particle (VLP)
Externí odkaz:
https://doaj.org/article/3bc86992a1b74b179c22119bd8416479
Autor:
Marina Amaral de Avila Machado, Cristiano S. Moura, Michal Abrahamowicz, Brian J. Ward, Louise Pilote, Sasha Bernatsky
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-6 (2021)
Abstract Influenza immunization protects seniors against influenza and its potentially serious complications. It is uncertain whether standard-dose (SD) quadrivalent vaccine offers better protection over other formulations in the elderly. In this stu
Externí odkaz:
https://doaj.org/article/16d34eec619e49e28a213b93a7fd6f96
Autor:
Joanne M. Langley, Soren Gantt, Caroline Quach, Julie A. Bettinger, Scott A. Halperin, Jill Mutch, Shelly A. McNeil, Brian J. Ward, Donna MacKinnon-Cameron, Lingyun Ye, Kim Marty, David Scheifele, Erin Brown, Joenel Alcantara
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 3, Pp 454-462 (2020)
Emergency vaccination programs often are needed to control outbreaks of meningococcal disease caused by Neisseria meningitidis serogroup B (MenB) on college campuses. Such campaigns expend multiple campus and public health resources. We conducted a r
Externí odkaz:
https://doaj.org/article/04902ddb4cd3493d8cc5b35557392d91
Autor:
Patrick Bodilly Kane, Hannah Moyer, Amanda MacPherson, Jesse Papenburg, Brian J. Ward, Stephen B. Broomell, Jonathan Kimmleman
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Objectives Compare lay expectations of medical development to those of experts in the context of SARS-CoV-2 vaccine development. Methods A short online survey of experts and lay people measuring when participants believe important vaccine milestones
Externí odkaz:
https://doaj.org/article/a6b12988de1940f4be4e4611493e21b5
Autor:
Shelly Bolotin, Alberto Severini, Todd Hatchette, Elizabeth McLachlan, Rachel Savage, Stephanie L. Hughes, John Wang, Shelley L. Deeks, Sarah Wilson, Marc Brisson, Scott A. Halperin, Jonathan Gubbay, Tony Mazzulli, Bouchra Serhir, Brian J. Ward, Natasha Crowcroft
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 15, Iss 12, Pp 2856-2864 (2019)
Canada eliminated measles in 1998. We conducted a sero-epidemiology study to estimate population immunity to measles in the province of Ontario, Canada and to identify groups at higher risk of outbreaks. We used a previously developed modified enzyme
Externí odkaz:
https://doaj.org/article/6f16902d185349e6b17ffb909928d3ce