Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Brian J. Wang"'
Autor:
José L. Montaño, Brian J. Wang, Regan F. Volk, Sara E. Warrington, Virginia G. Garda, Katherine L. Hofmann, Leo C. Chen, Balyn W. Zaro
Publikováno v:
ACS Chemical Biology. 17:1440-1449
Covalent inhibitors are viable therapeutics. However, off-target reactivity challenges the field. Chemists have attempted to solve this issue by varying the reactivity attributes of electrophilic warheads. Here, we report the development of an approa
Autor:
Matthew A. J. Duncton, Brian J Wang
Publikováno v:
The Journal of Organic Chemistry. 85:13317-13323
The azetidine group is frequently encountered within contemporary medicinal chemistry. However, the introduction of an azetidine can be synthetically challenging. Herein, a straightforward synthesis of azetidine-3-amines, starting from a bench stable
Autor:
Jiawei Sun, Pingyu Ding, Duncton Matthew A J, Zhi-Jie Ni, Ruslan Grygorash, Guijun Yu, Longwu Qi, Brian J Wang, Xianfeng Li, Eric M. Gordon, Dazhong Fan, Eddy Low
Publikováno v:
ACS Med Chem Lett
[Image: see text] Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is
Autor:
Brian J Wang, Matthew Duncton
The azetidine group is frequently encountered within contemporary medicinal chemistry where it is viewed as a privileged structure. However, the introduction of an azetidine can be synthetically challenging. Herein, a straight-forward one step synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b86685dfbf2c8f34eaa9259f27afe3
https://doi.org/10.26434/chemrxiv.12846629
https://doi.org/10.26434/chemrxiv.12846629
Autor:
Michael P. Groziak, Brian J. Wang
The utility of boron-containing compounds extends beyond the well-known applications of boronic acids and esters in Suzuki cross-couplings and enzyme inhibition. In this selective review, the last 15 years' worth of advances in the synthesis and util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35539437df309bc8b52bcfcbe6560f3
https://doi.org/10.1016/bs.aihch.2015.10.002
https://doi.org/10.1016/bs.aihch.2015.10.002