Výsledky vyhledávání - "Brian J. Van Lenten"

Akademický článek

Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid[S]

Autor: Mohamad Navab, Greg Hough, Georgette M. Buga, Feng Su, Alan C. Wagner, David Meriwether, Arnab Chattopadhyay, Feng Gao, Victor Grijalva, Janet S. Danciger, Brian J. Van Lenten, Elin Org, Aldons J. Lusis, Calvin Pan, G.M. Anantharamaiah, Robin Farias-Eisner, Susan S. Smyth, Srinivasa T. Reddy, Alan M. Fogelman

Publikováno v: Journal of Lipid Research, Vol 54, Iss 12, Pp 3403-3418 (2013)

We recently reported that levels of unsaturated lysophosphatidic acid (LPA) in the small intestine significantly correlated with the extent of aortic atherosclerosis in LDL receptor-null (LDLR−/−) mice fed a Western diet (WD). Here we demonstrate

Externí odkaz: https://doaj.org/article/1eb0b045b33349f5847f6f489f906e8c

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Akademický článek

A novel approach to oral apoA-I mimetic therapy[S]

Autor: Arnab Chattopadhyay, Mohamad Navab, Greg Hough, Feng Gao, David Meriwether, Victor Grijalva, James R. Springstead, Mayakonda N. Palgnachari, Ryan Namiri-Kalantari, Feng Su, Brian J. Van Lenten, Alan C. Wagner, G.M. Anantharamaiah, Robin Farias-Eisner, Srinivasa T. Reddy, Alan M. Fogelman

Publikováno v: Journal of Lipid Research, Vol 54, Iss 4, Pp 995-1010 (2013)

Transgenic tomato plants were constructed with an empty vector (EV) or a vector expressing an apoA-I mimetic peptide, 6F. EV or 6F tomatoes were harvested, lyophilized, ground into powder, added to Western diet (WD) at 2.2% by weight, and fed to LDL

Externí odkaz: https://doaj.org/article/7d5e61067aba46158bf7e2d6e0f492b1

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Akademický článek

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice[S]

Autor: Cynthia Hong, Michele N. Bradley, Xin Rong, Xuping Wang, Alan Wagner, Victor Grijalva, Lawrence W. Castellani, Jon Salazar, Susan Realegeno, Rima Boyadjian, Alan M. Fogelman, Brian J. Van Lenten, Srinivasa T. Reddy, Aldons J. Lusis, Rajendra K. Tangirala, Peter Tontonoz

Publikováno v: Journal of Lipid Research, Vol 53, Iss 6, Pp 1126-1133 (2012)

The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRα, the dominant LXR isotype expressed in live

Externí odkaz: https://doaj.org/article/ff30e527bbf84aa4bcabb5bb64d96c53

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Akademický článek

Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I

Autor: Brian J. Van Lenten, Alan C. Wagner, Chun-Ling Jung, Piotr Ruchala, Alan J. Waring, Robert I. Lehrer, Andrew D. Watson, Susan Hama, Mohamad Navab, G.M. Anantharamaiah, Alan M. Fogelman

Publikováno v: Journal of Lipid Research, Vol 49, Iss 11, Pp 2302-2311 (2008)

4F is an anti-inflammatory, apolipoprotein A-I (apoA-I)-mimetic peptide that is active in vivo at nanomolar concentrations in the presence of a large molar excess of apoA-I. Physiologic concentrations (∼35 μM) of human apoA-I did not inhibit the p

Externí odkaz: https://doaj.org/article/52f74bd84e904fa99c792f2fe031fac0

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Akademický článek

Lipoprotein inflammatory properties and serum amyloid A levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits

Autor: Brian J. Van Lenten, Alan C. Wagner, Mohamad Navab, G.M. Anantharamaiah, Susan Hama, Srinivasa T. Reddy, Alan M. Fogelman

Publikováno v: Journal of Lipid Research, Vol 48, Iss 11, Pp 2344-2353 (2007)

Rabbits on a 1% cholesterol diet received injections of vehicle with or without D-4F or L-4F. After 1 month, the percent of aorta with atherosclerotic lesions was 24 ± 15% (vehicle), 10 ± 6% (D-4F) (P < 0.01 vs. vehicle), and 13 ± 9% (L-4F) (P < 0

Externí odkaz: https://doaj.org/article/a4635c44e93f4806819416d120b251c8

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Akademický článek

Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL

Autor: Mohamad Navab, G.M. Ananthramaiah, Srinivasa T. Reddy, Brian J. Van Lenten, Benjamin J. Ansell, Gregg C. Fonarow, Kambiz Vahabzadeh, Susan Hama, Greg Hough, Naeimeh Kamranpour, Judith A. Berliner, Aldons J. Lusis, Alan M. Fogelman

Publikováno v: Journal of Lipid Research, Vol 45, Iss 6, Pp 993-1007 (2004)

For more than two decades, there has been continuing evidence of lipid oxidation playing a central role in atherogenesis. The oxidation hypothesis of atherogenesis has evolved to focus on specific proinflammatory oxidized phospholipids that result fr

Externí odkaz: https://doaj.org/article/dd7f7e8dff4d4d37867cb58a9fe39236

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Akademický článek

The role of dysfunctional HDL in atherosclerosis

Autor: Mohamad Navab, Srinivasa T. Reddy, Brian J. Van Lenten, G.M. Anantharamaiah, Alan M. Fogelman

Publikováno v: Journal of Lipid Research, Vol 50, Iss , Pp S145-S149 (2009)

This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory

Externí odkaz: https://doaj.org/article/0784287469bc45cf897cd5feb9c255a0

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Proinflammatory High‐Density Lipoprotein Results from Oxidized Lipid Mediators in the Pathogenesis of Both Idiopathic and Associated Types of Pulmonary Arterial Hypertension

Autor: Susan Hama, Mansoureh Eghbali, Brian J. Van Lenten, Greg Hough, Alan M. Fogelman, John A. Belperio, Abbas Ardehali, Srinivasa T. Reddy, Mohamad Navab, David J. Ross, Jamil Aboulhosn, Rajan Saggar

Publikováno v: Pulmonary circulation, vol 5, iss 4

Pulmonary arterial hypertension (PAH) is characterized by abnormal elaboration of vasoactive peptides, endothelial cell dysfunction, vascular remodeling, and inflammation, which collectively contribute to its pathogenesis. We investigated the potenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701426a23aa4a55798ae1aac75a6aeae
https://doi.org/10.1086/683695

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High-Density Lipoprotein and 4F Peptide Reduce Systemic Inflammation by Modulating Intestinal Oxidized Lipid Metabolism

Autor: Greg Hough, Alan C. Wagner, Brian J. Van Lenten, Alan M. Fogelman, Srinivasa T. Reddy, Mohamad Navab, Georgette M. Buga

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology

Oxidized phospholipids are found in the vasculature of animal models of atherosclerosis, in human atherosclerotic lesions, and in other inflammatory diseases. Oxidized phospholipids cause vascular and nonvascular cells to initiate an inflammatory rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2686693d95bb9096015906224ab8bbde

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LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice[S]

Autor: Alan M. Fogelman, Cynthia Hong, Srinivasa T. Reddy, Victor Grijalva, Alan C. Wagner, Susan Realegeno, Brian J. Van Lenten, Xin Rong, Lawrence W. Castellani, Rima Boyadjian, Peter Tontonoz, Michelle N. Bradley, Jon Salazar, Rajendra K. Tangirala, Xuping Wang, Aldons J. Lusis

Publikováno v: Journal of Lipid Research, Vol 53, Iss 6, Pp 1126-1133 (2012)
Journal of Lipid Research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2413549ce1e2bb1298d8a001524fe52e
http://www.sciencedirect.com/science/article/pii/S0022227520317053

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