Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Brian J. Siroky"'
Autor:
Steven J Kleene, Brian J Siroky, Julio A Landero-Figueroa, Bradley P Dixon, Nolan W Pachciarz, Lu Lu, Nancy K Kleene
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214053 (2019)
Primary cilia of renal epithelial cells express several members of the transient receptor potential (TRP) class of cation-conducting channel, including TRPC1, TRPM3, TRPM4, TRPP2, and TRPV4. Some cases of autosomal dominant polycystic kidney disease
Externí odkaz:
https://doaj.org/article/be21d27a5729441384f21ae60bb2e47f
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16595 (2011)
Children with complex urogenital anomalies often require bladder reconstruction. Gastrointestinal tissues used in bladder augmentations exhibit a greatly increased risk of malignancy, and the bladder microenvironment may play a role in this carcinoge
Externí odkaz:
https://doaj.org/article/464cdffd248c45b7bfedf7ec0aa5d4ba
Autor:
Xiaolei Liu, Elizabeth J. Kopras, Yang Liu, Chenggang Li, Anya Alayev, David R. Plas, Erik Zhang, Kantha Medepalli, Kouhei Masuda, Brian J. Siroky, David J. Kwiatkowski, Yang Sun, Marina K. Holz, Julia Sun, David Neal Franz, Michael T. Borchers, Darcy A. Krueger, Jamie K. Capal, Kathryn A. Wikenheiser-Brokamp, Jane J. Yu, Andrew R. Osterburg, Na Li, Maxwell Mays
Publikováno v:
Molecular Cancer Research. 15:1318-1330
Tuberous sclerosis complex (TSC) is a tumor-suppressor syndrome affecting multiple organs, including the brain, skin, kidneys, heart, and lungs. TSC is associated with mutations in TSC1 or TSC2, resulting in hyperactivation of mTOR complex 1 (mTORC1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c46b81a990633960c5b18a7060006b
https://doi.org/10.1158/1541-7786.mcr-17-0077
https://doi.org/10.1158/1541-7786.mcr-17-0077
Autor:
Keri Anne Drake, Prasad Devarajan, Brian J. Siroky, Kritton Shay-Winkler, Priyanka Parameswaran, LaTawnya Pleasant, Qing Ma, Jeffrey Robbins, Mahima Devarajan
Publikováno v:
American Journal of Physiology-Renal Physiology. 313:F699-F705
The early events that signal renal dysfunction in presymptomatic heart failure are unclear. We tested the hypothesis that functional and mechanistic changes occur in the kidney that precede the development of symptomatic heart failure. We employed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a446478b2fa6ef0d2dd83e6739f027
https://doi.org/10.1152/ajprenal.00505.2016
https://doi.org/10.1152/ajprenal.00505.2016
Autor:
Jialiu Liu, Nancy K. Kleene, Nolan W. Pachciarz, Raven G. Comer, Steven J. Kleene, Bradley P. Dixon, Lu Lu, Brian J. Siroky, John J. Bissler, Charles D. Varnell
Publikováno v:
American Journal of Physiology-Renal Physiology. 312:F791-F805
Primary cilia sense environmental conditions, including osmolality, but whether cilia participate in the osmotic response in renal epithelial cells is not known. The transient receptor potential (TRP) channels TRPV4 and TRPM3 are osmoresponsive. TRPV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d209a4358d147bba20a872f74677a948
https://doi.org/10.1152/ajprenal.00465.2015
https://doi.org/10.1152/ajprenal.00465.2015
Autor:
Charilaos Filippakis, Amine Belaid, Brian J. Siroky, Julie Nijmeh, Thomas Alesi, Nicola Alesi, Ellizabeth Henske, Constance Wu, Hilaire C. Lam
Publikováno v:
Molecular Cancer Research. 18:A01-A01
Purpose: The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) is constitutively active in many human cancers and in tuberous sclerosis complex (TSC). mTORC1 hyperactivation drives extensive metabolic reprogramming via several interconnect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10aa98001edd13e0bb8e292c040e3610
https://doi.org/10.1158/1557-3125.pi3k-mtor18-a01
https://doi.org/10.1158/1557-3125.pi3k-mtor18-a01
Publikováno v:
Nature reviews. Nephrology. 14(11)
Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by hamartomatous tumours of the brain, heart, skin, lung and kidney. Patients with TSC show a diverse range of neurological features (including seizures, cognitive disabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab11b62a0735fdcf8d082f695a17671
https://pubmed.ncbi.nlm.nih.gov/30232410
https://pubmed.ncbi.nlm.nih.gov/30232410
Autor:
Nicola Alesi, Brian J. Siroky, Hilaire C. Lam, Thomas Hougard, Harilaos Filippakis, Amine Belaid, Constance Wu, Julie Nijmeh, Elizabeth P. Henske
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Tuberous Sclerosis Complex (TSC), a rare genetic disorder with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivation, is characterized by multi-organ hamartomatous benign tumors including brain, skin, kidney, and lung (Lymphangioleiomyom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e46e67889644692827a4a0a1edd5f6
https://pubmed.ncbi.nlm.nih.gov/30242175
https://pubmed.ncbi.nlm.nih.gov/30242175
Loss of matrix metalloproteinase-8 is associated with worsened recovery after ischemic kidney injury
Publikováno v:
Renal Failure. 37:469-475
Acute kidney injury (AKI) leads to chronic kidney disease. The mechanisms involved with recovery from AKI are poorly understood and molecular mediators responsible for healing and restoration of kidney function are understudied. We previously discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9816b345534341f8544481ef8bb26056
https://doi.org/10.3109/0886022x.2014.996842
https://doi.org/10.3109/0886022x.2014.996842
Autor:
Karen Agricola, Cynthia Tudor, Jamie K. Capal, Hannah Schäfer, Brian J. Siroky, David Neal Franz, Darcy A. Krueger, Anna R. Thamann, Bradley P. Dixon, Andrew T. Trout, Alexander J. Towbin
Publikováno v:
The Journal of pediatrics. 187
Renal cysts occur in approximately 50% of patients with tuberous sclerosis complex, but their clinical significance and response to treatment are unknown. Abdominal imaging of 15 patients with tuberous sclerosis complex-associated renal cystic diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304f4c13f314eaae1772943fb94e3386
https://pubmed.ncbi.nlm.nih.gov/28600153
https://pubmed.ncbi.nlm.nih.gov/28600153