Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Brian J. Marquardt"'
Autor:
Anna Formosa, Brian J. Marquardt, Luke Rogers, Yuma Miyai, Cameron Armstrong, Thomas D. Roper
Publikováno v:
Organic Process Research & Development. 25:2707-2717
The strategies and experimental methods for implementation of process analytical technology (PAT) on the mobile pharmaceutical manufacturing system, Pharmacy on Demand (PoD), are discussed. With mu...
Autor:
Cameron T, Armstrong, Cailean Q, Pritchard, Daniel W, Cook, Mariam, Ibrahim, Bimbisar K, Desai, Patrick J, Whitham, Brian J, Marquardt, Yizheng, Chen, Jeremie T, Zoueu, Michael J, Bortner, Thomas D, Roper
Publikováno v:
Reaction Chemistry & Engineering
Continuous flow chemistry has the potential to greatly improve efficiency in the synthesis of active pharmaceutical ingredients (APIs); however, the optimization of these processes can be complicated by a large number of variables affecting reaction
Autor:
Michael F. Roberto, Olav M. Kvalheim, Thomas I. Dearing, Olav Bleie, Charles W. Branham, Brian J. Marquardt
Publikováno v:
Journal of Flow Chemistry. 5:183-189
The Moffatt-Swern oxidation (MSO) is a multistep, versatile, metal-free reaction by which alcohols are transformed into aldehydes and ketones. Batch MSO requires low temperatures (−70 °C) due to a highly exothermic reaction step that generates int
Publikováno v:
Journal of Pharmaceutical Innovation. 7:69-75
The pharmaceutical industry has great need to reduce costs and improve manufacturing efficiency while consistently manufacturing quality drug product. Continuous flow reactors (CFRs) offer an option for a flexible, leaner, and cleaner process. CFRs a
Publikováno v:
Applied Spectroscopy. 65:181-186
Process Raman, infrared (IR), and nuclear magnetic resonance (NMR) analyses are currently being performed in industrial settings for the monitoring of large scale reactions. These methods offer a distinct set of advantages such as no sample preparati
Publikováno v:
CrystEngComm. 13:1123-1126
Descriptions of polycrystalline patterns require the quantitative characterization of the organization of many crystallites. Automated linear birefringence imaging systems developed during the past 15 years are well suited to mapping crystallite orie
Publikováno v:
Applied Spectroscopy. 59:1324-1332
Raman and near-infrared (NIR) spectroscopy have been evaluated for determining fatty acid composition and contents of main constituents in a complex food model system. A model system consisting of 70 different mixtures of protein, water, and oil blen
Publikováno v:
Sensors and Actuators B: Chemical. :230-241
This paper presents results from an electronic interface that significantly improves the stability, power output, and spectral flexibility of light emitting diode (LED)-based systems used to excite fluorescence or other forms of luminescence. LEDs ar
Publikováno v:
Analytica Chimica Acta. 544:71-81
This paper describes a novel approach to multivariate curve resolution (MCR) for rapid resolution of low-resolution chromatographic data from complex mixtures collected using a liquid-core Raman waveguide detector. Pure spectra with individual chroma
Publikováno v:
Applied Spectroscopy. 58:395-403
Raman spectroscopy (785 nm excitation) was used to determine the overall carotenoid (astaxanthin and cantaxanthin) and fat content in 49 samples of ground muscle tissue from farmed Atlantic salmon ( Salmo salar L.). Chemically determined contents ran