Výsledky vyhledávání - "Brian J. Ledwith"

Akademický článek

Simultaneous Purification of RNA and DNA from Liver Using Sodium Acetate Precipitation

Autor: Judith K. Evans, Philip Troilo, Brian J. Ledwith

Publikováno v: BioTechniques, Vol 24, Iss 3, Pp 416-418 (1998)

Externí odkaz: https://doaj.org/article/c8b60e4dcfa5462c8af4dfaf90aa889e

Characterization of integration frequency and insertion sites of adenovirus DNA into mouse liver genomic DNA following intravenous injection

Autor: Zhibin, Wang, Philip J, Troilo, Thomas G, Griffiths, Laural B, Harper, Amy B, Barnum, Stephen J, Pacchione, Cindy J, Pauley, Jose A, Lebron, Jayanthi, Wolf, Brian J, Ledwith

Publikováno v: Gene therapy. 29(6)

While generally referred to as "non-integrating" vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate (nonhomologous) recombination. The present study provides a quantitative assessment of the potential i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5ccc71c22ad494506ad0ada50fa9db1
https://pubmed.ncbi.nlm.nih.gov/34404916

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Plasmid DNA Vaccines: Investigation of Integration into Host Cellular DNA following Intramuscular Injection in Mice

Autor: Cindy J. Pauley, Warren W. Nichols, Carolann M. Beare, Amy B. Barnum, Sujata Manam, Walter J. Bagdon, Philip J. Troilo, Brian J. Ledwith, Laural B. Harper, Thomas G. Griffiths

Publikováno v: Intervirology. 43:258-272

The primary safety concern for DNA vaccines is their potential to integrate into the host cell genome. We describe an integration assay based on purification of high-molecular-weight genomic DNA away from free plasmid using gel electrophoresis, such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69a9a146e0bf5dbd4a9662a6afe7cfe
https://doi.org/10.1159/000053993

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Peroxisome Proliferators Activate Extracellular Signal-regulated Kinases in Immortalized Mouse Liver Cells

Autor: Brian J. Ledwith, Carrie L. Rokos

Publikováno v: Journal of Biological Chemistry. 272:13452-13457

Peroxisome proliferators (PPs) are a class of nongenotoxic carcinogens in the rodent liver. The induction of immediate-early gene expression in immortalized mouse liver cells by the PPs Wy-14, 643, monoethylhexyl phthalate, ciprofibrate ethyl ester,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbc4302c405b01b5b9aa4c664a4d727
https://doi.org/10.1074/jbc.272.20.13452

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Minisatellite DNA-Binding Proteins in Mouse Brain, Liver, and Kidney

Autor: Brian J. Ledwith, Warren W. Nichols, Gayle A. Shinder, Sujata Manam

Publikováno v: Experimental Cell Research. 213:107-112

Minisatellites are tandemly repeated DNA sequences that are found in most higher eukaryotes. They are genetically unstable and often gain or lose repeat units. Minisatellite repeats contain a "core" sequence which is highly conserved among a family o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44f87ed1ac4663a05463164724f5926
https://doi.org/10.1006/excr.1994.1179

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Activation of immediate-early gene expression by peroxisome proliferators in vitro

Autor: Philip Troilo, Dennis J. Joslyn, S. M. Galloway, Sujata Manam, Warren W. Nichols, Brian J. Ledwith

Publikováno v: Molecular Carcinogenesis. 8:20-27

The hepatocarcinogenicity of peroxisome proliferators (PPs) in rodents has been attributed both to oxidative DNA damage resulting from excessive leakage of peroxisomal H2O2 and to increased hepatocellular replication that may be independent of peroxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8fd4af76995e0df3fc37b02b3e93e2
https://doi.org/10.1002/mc.2940080107

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Nonclinical testing of vaccines: Report from a workshop

Autor: Roy Forster, Sarah Gould, Lawrence Segal, Brian J. Ledwith, Andrée Penninks, Marion Gruber, Jan Willem van der Laan

Publikováno v: Drug Information Journal, 1, 43, 97-107

Vaccine research and development is a heterogeneous and intensely active area, encompassing the development of many different kinds of novel preventive and therapeutic vaccines (eg, against infectious, allergic, and autoimmune diseases, cancer, etc).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6c190ee8abe1f689038e7615a1d877
http://resolver.tudelft.nl/uuid:535b3f90-3d3e-4454-b77a-9a315406fd9c

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Lack of effects on fertility and developmental toxicity of a quadrivalent HPV vaccine in Sprague-Dawley rats

Autor: L. David Wise, Cindy J. Pauley, Jayanthi J. Wolf, Catherine Kaplanski, Brian J. Ledwith

Publikováno v: Birth defects research. Part B, Developmental and reproductive toxicology. 83(6)

Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases, with approximately half of the HPV-infected people being adolescents and young adults. A recently developed quadrivalent HPV vaccine, GARDASIL((R)), has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2efbb786c68ebb609b005dde4bacd3
https://pubmed.ncbi.nlm.nih.gov/19025783

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