Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Brian J. Larsen"'
Publikováno v:
Tetrahedron. 74:2762-2768
The 1,3-indandione scaffold is an important structural motif used in the preparation of a large number of industrial chemical and pharmaceutical compounds. However, few approaches allow for the direct C2 acylation on these building blocks. A method w
Autor:
Trevor Selwood, Brian J. Larsen, Charlie Y. Mo, Matthew J. Culyba, Zachary M. Hostetler, Rahul M. Kohli, Allen B. Reitz, Simon D. P. Baugh
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 9 (2018)
Frontiers in Microbiology, Vol 9 (2018)
Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response
Autor:
Matthew B. Soellner, Eric J. Lachacz, Brian J. Larsen, Yaroslav Khomutnyk, Pavel Nagorny, Zhankui Sun
Publikováno v:
Chemistry – A European Journal. 21:19159-19167
The studies culminating in the total synthesis of the glutarimide-containing eukaryote translation elongation inhibitor lactimidomycin are described. The optimized synthetic route features a Zn(II)-mediated intramolecular Horner-Wadsworth-Emmons (HWE
Publikováno v:
Organic letters. 15(12)
An enantioselective synthesis of potent eukaryotic translation elongation inhibitor lactimidomycin has been accomplished in 21 linear steps. This synthesis features a Zn(II)-mediated Horner–Wadsworth–Emmons reaction that could be executed on a la