Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Brian J. Laight"'
Autor:
Brian J. Laight, Natasha A. Jawa, Kathrin Tyryshkin, David M. Maslove, J. Gordon Boyd, Peter A. Greer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSepsis is a result of initial over-activation of the immune system in response to an infection or trauma that results in reduced blood flow and life-threatening end-organ damage, followed by suppression of the immune system that prevents
Externí odkaz:
https://doaj.org/article/1ac1ce10d21644db81c691534adf5743
Autor:
Madhuri Koti, Stephen Chenard, Ali Hamade, Noor Shakfa, Deyang Li, Gwenaelle Conseil, Elizabeth D Lightbody, Juliette Wilson-Sanchez, Natasha A. Jawa, Brian J. Laight, Afrakoma Afriyie-Asante, Kathrin Tyryshkin, Martin Koebel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background High-grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy characterized by resistance to chemotherapy and high rates of recurrence. HGSC tumors display a high prevalence of tumor suppressor gene loss. Given the t
Externí odkaz:
https://doaj.org/article/efaa5a34fcf548638e10eaee0c1e7c15
Autor:
Marie-Eve Wedge, Victoria A. Jennings, Mathieu J. F. Crupi, Joanna Poutou, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J. Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E. McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza Rezaei, Bradley Austin, Xiaohong He, David Mansfield, Elaine Rose, Emily E. F. Brown, Natalie Crawford, Almohanad Alkayyal, Abera Surendran, Ragunath Singaravelu, Dominic G. Roy, Gemma Migneco, Benjamin McSweeney, Mary Lynn Cottee, Egon J. Jacobus, Brian A. Keller, Takafumi N. Yamaguchi, Paul C. Boutros, Michele Geoffrion, Katey J. Rayner, Avijit Chatterjee, Rebecca C. Auer, Jean-Simon Diallo, Derrick Gibbings, Benjamin R. tenOever, Alan Melcher, John C. Bell, Carolina S. Ilkow
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
RNA-based viruses can be engineered to express artificial microRNAs (amiRNAs). Here, the authors identify a candidate amiRNA that confers a replicative advantage to oncolytic viruses, enhancing their anticancer potency, and show that intercellular tr
Externí odkaz:
https://doaj.org/article/4c63ee51ae0d403a99532dab542cb349
Autor:
Victoria Hoskin, Abdi Ghaffari, Brian J. Laight, Sandip SenGupta, Yolanda Madarnas, Christopher J.B. Nicol, Bruce E. Elliott, Sonal Varma, Peter A. Greer
Publikováno v:
Cancer Research Communications. 2:456-470
The main cause of cancer-associated deaths is the spread of cancer cells to distant organs. Despite its success in the primary tumor setting, modern chemotherapeutic strategies are rendered ineffective at treating metastatic disease, largely due to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e69d7b66c13b077c25f7d4c1b563cd55
https://doi.org/10.1158/2767-9764.crc-21-0117
https://doi.org/10.1158/2767-9764.crc-21-0117
Autor:
Peter A. Greer, Sonal Varma, Bruce E. Elliott, Christopher J.B. Nicol, Yolanda Madarnas, Sandip SenGupta, Brian J. Laight, Abdi Ghaffari, Victoria Hoskin
Ezrin protein expression after DOX and DTX drug challenge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd9d4a1e5ae0c69efa98ab7075b1796
https://doi.org/10.1158/2767-9764.22544618.v1
https://doi.org/10.1158/2767-9764.22544618.v1
Autor:
Peter A. Greer, Sonal Varma, Bruce E. Elliott, Christopher J.B. Nicol, Yolanda Madarnas, Sandip SenGupta, Brian J. Laight, Abdi Ghaffari, Victoria Hoskin
Common gene mutations or amplifications found in the BC cell line panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861e87ddec0f662cab8b413d444a43c2
https://doi.org/10.1158/2767-9764.22544615
https://doi.org/10.1158/2767-9764.22544615
Autor:
Peter A. Greer, Sonal Varma, Bruce E. Elliott, Christopher J.B. Nicol, Yolanda Madarnas, Sandip SenGupta, Brian J. Laight, Abdi Ghaffari, Victoria Hoskin
The main cause of cancer-associated deaths is the spread of cancer cells to distant organs. Despite its success in the primary tumor setting, modern chemotherapeutic strategies are rendered ineffective at treating metastatic disease, largely due to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040c0ab51b166d763edd01a1265c45df
https://doi.org/10.1158/2767-9764.c.6550703.v1
https://doi.org/10.1158/2767-9764.c.6550703.v1
Autor:
Noor Shakfa, Deyang Li, Gwenaelle Conseil, Elizabeth D Lightbody, Juliette Wilson-Sanchez, Ali Hamade, Stephen Chenard, Natasha A. Jawa, Brian J. Laight, Afrakoma Afriyie-Asante, Kathrin Tyryshkin, Martin Koebel, Madhuri Koti
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e006170
BackgroundHigh-grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy characterized by resistance to chemotherapy and high rates of recurrence. HGSC tumors display a high prevalence of tumor suppressor gene loss. Given the ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f3b9aa17b30067787eeb6bf9689389c
https://doi.org/10.1136/jitc-2022-006170
https://doi.org/10.1136/jitc-2022-006170
Autor:
Michael Ong, Bryan Lo, Marie-Ève Wedge, Carolina S. Ilkow, John C. Bell, Catia Cemeus, Oliver Varette, Aron Broom, Benjamin McSweeney, Bruce F. Burns, Harold L. Atkins, Brian J Laight, Julia Petryk, Brian A. Keller, Jean-Simon Diallo, Carolyn Nessim, Roberto A. Chica
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 147:1365-1378
Mutations in BRAF are the most prominent activating mutations in melanoma and are increasingly recognized in other cancers. There is currently no accepted treatment regimen for patients with mutant BRAFK601N melanoma, and the study of melanoma driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ae1f24727701df369e59dd2c32a58f0
https://doi.org/10.1007/s00432-021-03545-2
https://doi.org/10.1007/s00432-021-03545-2
Autor:
Marie-Eve Wedge, Victoria A. Jennings, Mathieu J. F. Crupi, Joanna Poutou, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J. Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E. McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza Rezaei, Bradley Austin, Xiaohong He, David Mansfield, Elaine Rose, Emily E. F. Brown, Natalie Crawford, Almohanad Alkayyal, Abera Surendran, Ragunath Singaravelu, Dominic G. Roy, Gemma Migneco, Benjamin McSweeney, Mary Lynn Cottee, Egon J. Jacobus, Brian A. Keller, Takafumi N. Yamaguchi, Paul C. Boutros, Michele Geoffrion, Katey J. Rayner, Avijit Chatterjee, Rebecca C. Auer, Jean-Simon Diallo, Derrick Gibbings, Benjamin R. tenOever, Alan Melcher, John C. Bell, Carolina S. Ilkow
Publikováno v:
Nature communications, vol 13, iss 1
Recent advances in cancer therapeutics clearly demonstrate the need for innovative multiplex therapies that attack the tumour on multiple fronts. Oncolytic or “cancer-killing” viruses (OVs) represent up-and-coming multi-mechanistic immunotherapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68ee2ef0a895547c59e7429cd83a59b
https://pubmed.ncbi.nlm.nih.gov/35393414
https://pubmed.ncbi.nlm.nih.gov/35393414