Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Brian J. Golbourn"'
Autor:
Esther P. Jane, Matthew C. Reslink, Taylor A. Gatesman, Matthew E. Halbert, Tracy A. Miller, Brian J. Golbourn, Stephanie M. Casillo, Steven J. Mullett, Stacy G. Wendell, Udochukwu Obodo, Dinesh Mohanakrishnan, Riya Dange, Antony Michealraj, Charles Brenner, Sameer Agnihotri, Daniel R. Premkumar, Ian F. Pollack
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1821-1843 (2023)
In previous studies, we demonstrated that panobinostat, a histone deacetylase inhibitor, and bortezomib, a proteasomal inhibitor, displayed synergistic therapeutic activity against pediatric and adult high‐grade gliomas. Despite the remarkable init
Externí odkaz:
https://doaj.org/article/855c1c665c7544d3830b200c1e512815
Autor:
Stephanie M. Casillo, Taylor A. Gatesman, Akanksha Chilukuri, Srinidhi Varadharajan, Brenden J. Johnson, Daniel R. David Premkumar, Esther P. Jane, Tritan J. Plute, Robert F. Koncar, Ann-Catherine J. Stanton, Carlos A.O. Biagi-Junior, Callie S. Barber, Matthew E. Halbert, Brian J. Golbourn, Katharine Halligan, Andrea F. Cruz, Neveen M. Mansi, Allison Cheney, Steven J. Mullett, Clinton Van’t Land, Jennifer L. Perez, Max I. Myers, Nishant Agrawal, Joshua J. Michel, Yue-Fang Chang, Olena M. Vaske, Antony MichaelRaj, Frank S. Lieberman, James Felker, Sruti Shiva, Kelsey C. Bertrand, Nduka Amankulor, Costas G. Hadjipanayis, Kalil G. Abdullah, Pascal O. Zinn, Robert M. Friedlander, Taylor J. Abel, Javad Nazarian, Sriram Venneti, Mariella G. Filbin, Stacy L. Gelhaus, Stephen C. Mack, Ian F. Pollack, Sameer Agnihotri
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113557- (2024)
Summary: Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways. Previous stu
Externí odkaz:
https://doaj.org/article/a1cfb726d57743518bf0449e2947643f
Autor:
Shideh Mirhadi, Shirley Tam, Quan Li, Nadeem Moghal, Nhu-An Pham, Jiefei Tong, Brian J. Golbourn, Jonathan R. Krieger, Paul Taylor, Ming Li, Jessica Weiss, Sebastiao N. Martins-Filho, Vibha Raghavan, Yasin Mamatjan, Aafaque A. Khan, Michael Cabanero, Shingo Sakashita, Kugeng Huo, Sameer Agnihotri, Kota Ishizawa, Thomas K. Waddell, Gelareh Zadeh, Kazuhiro Yasufuku, Geoffrey Liu, Frances A. Shepherd, Michael F. Moran, Ming-Sound Tsao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
With non-small cell lung cancer (NSCLC) being the leading cause of cancer deaths worldwide, the development of targeted therapies remains crucial. Here, the generation and multi-omics characterization of 137 NSCLC patient-derived xenografts provides
Externí odkaz:
https://doaj.org/article/ca6f25a2b4ee419cb65ec4d91e659e4f
Autor:
Stephen C. Mack, Benjamin Deneen, Kelsey C. Bertrand, Claudia L. Kleinman, Nada Jabado, Joanna Yi, Richard J. Gilbertson, Sameer Agnihotri, Kristian W. Pajtler, Donald W. Parsons, Susan M. Blaney, Murali M. Chintagumpala, Thomas F. Westbrook, Irtisha Singh, H. Courtney Hodges, Charles Y. Lin, Stefan M. Pfister, Daisuke Kawauchi, Felix Sahm, Luz A. De León, Peter R. Wang, Madeline Ngo, Sarah G. Injac, Baoli Hu, Robert Kupp, Kathleen Kong, Kristen L. Karlin, Calla Olson, Yuen San Chan, Ann-Catherine J. Stanton, Brian J. Golbourn, Dana Tlais, Alisha Kardian, Minerva Solis, Austin J. Stuckert, Bryan Rivas, Selin Jessa, Hsiao-Chi Chen, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade
93 gene signature that characterizes ZFTA-Rela mouse and human tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2455a45bb7a7160f6ff2e0c7dedb37da
https://doi.org/10.1158/2159-8290.22539655.v1
https://doi.org/10.1158/2159-8290.22539655.v1
Autor:
Stephen C. Mack, Benjamin Deneen, Kelsey C. Bertrand, Claudia L. Kleinman, Nada Jabado, Joanna Yi, Richard J. Gilbertson, Sameer Agnihotri, Kristian W. Pajtler, Donald W. Parsons, Susan M. Blaney, Murali M. Chintagumpala, Thomas F. Westbrook, Irtisha Singh, H. Courtney Hodges, Charles Y. Lin, Stefan M. Pfister, Daisuke Kawauchi, Felix Sahm, Luz A. De León, Peter R. Wang, Madeline Ngo, Sarah G. Injac, Baoli Hu, Robert Kupp, Kathleen Kong, Kristen L. Karlin, Calla Olson, Yuen San Chan, Ann-Catherine J. Stanton, Brian J. Golbourn, Dana Tlais, Alisha Kardian, Minerva Solis, Austin J. Stuckert, Bryan Rivas, Selin Jessa, Hsiao-Chi Chen, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade
Figure S2 supporting expression and localization of ZRfus in the mouse IUE model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5100705dc6a0f49c6241a385bfa4fe37
https://doi.org/10.1158/2159-8290.22539676
https://doi.org/10.1158/2159-8290.22539676
Autor:
Stephen C. Mack, Benjamin Deneen, Kelsey C. Bertrand, Claudia L. Kleinman, Nada Jabado, Joanna Yi, Richard J. Gilbertson, Sameer Agnihotri, Kristian W. Pajtler, Donald W. Parsons, Susan M. Blaney, Murali M. Chintagumpala, Thomas F. Westbrook, Irtisha Singh, H. Courtney Hodges, Charles Y. Lin, Stefan M. Pfister, Daisuke Kawauchi, Felix Sahm, Luz A. De León, Peter R. Wang, Madeline Ngo, Sarah G. Injac, Baoli Hu, Robert Kupp, Kathleen Kong, Kristen L. Karlin, Calla Olson, Yuen San Chan, Ann-Catherine J. Stanton, Brian J. Golbourn, Dana Tlais, Alisha Kardian, Minerva Solis, Austin J. Stuckert, Bryan Rivas, Selin Jessa, Hsiao-Chi Chen, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade
More than 60% of supratentorial ependymomas harbor a ZFTA–RELA (ZRfus) gene fusion (formerly C11orf95–RELA). To study the biology of ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3a974b88b13a244bee5e4ff38026e0
https://doi.org/10.1158/2159-8290.c.6549148.v1
https://doi.org/10.1158/2159-8290.c.6549148.v1
Autor:
James T. Rutka, Michael D. Taylor, Christian A. Smith, Andrey Korshunov, Marcel Kool, Sidney E. Croul, Stefan M. Pfister, Paul A. Northcott, Martin Post, Leonardo Ermini, Denis Reynaud, Michael Leadley, Xin Wang, Stephen C. Mack, Vijay Ramaswamy, Livia Garzia, Xiaochong Wu, Samantha Olsen, Nesrin Sabha, Amanda Luck, Sameer Agnihotri, Roberto J. Diaz, Marc Remke, Adrian M. Dubuc, Brian J. Golbourn, Claudia C. Faria
Supplementary Figure S5. PDGFRÃ? pathway inhibition in foretinib treated Daoy and D425 medulloblastoma cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df35ef82567a7a5c428c04806f2c274
https://doi.org/10.1158/0008-5472.22405100.v1
https://doi.org/10.1158/0008-5472.22405100.v1
Autor:
James T. Rutka, Michael D. Taylor, Christian A. Smith, Andrey Korshunov, Marcel Kool, Sidney E. Croul, Stefan M. Pfister, Paul A. Northcott, Martin Post, Leonardo Ermini, Denis Reynaud, Michael Leadley, Xin Wang, Stephen C. Mack, Vijay Ramaswamy, Livia Garzia, Xiaochong Wu, Samantha Olsen, Nesrin Sabha, Amanda Luck, Sameer Agnihotri, Roberto J. Diaz, Marc Remke, Adrian M. Dubuc, Brian J. Golbourn, Claudia C. Faria
Supplementary Table S1. Foretinib concentrations in mouse brain, mouse plasma and the brain-plasma ratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423501a2f8d8cc17536641ffc1b3e97c
https://doi.org/10.1158/0008-5472.22405088.v1
https://doi.org/10.1158/0008-5472.22405088.v1
Autor:
James T. Rutka, Michael D. Taylor, Christian A. Smith, Andrey Korshunov, Marcel Kool, Sidney E. Croul, Stefan M. Pfister, Paul A. Northcott, Martin Post, Leonardo Ermini, Denis Reynaud, Michael Leadley, Xin Wang, Stephen C. Mack, Vijay Ramaswamy, Livia Garzia, Xiaochong Wu, Samantha Olsen, Nesrin Sabha, Amanda Luck, Sameer Agnihotri, Roberto J. Diaz, Marc Remke, Adrian M. Dubuc, Brian J. Golbourn, Claudia C. Faria
Supplementary Methods and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9b0b84de00f02c84bc50d9a51fafcc
https://doi.org/10.1158/0008-5472.22405091
https://doi.org/10.1158/0008-5472.22405091
Autor:
null Esther P. Jane, null Matthew C. Reslink, null Taylor Gatesman, null Matthew Halbert, null Tracy A. Miller, null Brian J. Golbourn, null Stephanie M. Casillo, null Steven J. Mullett, null Stacy G. Wendell, null Udochukwu Obodo, null Dinesh Mohanakrishnan, null Riya Dange, null Antony Michealraj, null Charles Brenner, null Sameer Agnihotri, null Daniel R. Premkumar, null Ian F. Pollack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c7f0fb02506d87d34cc0eeab21fd927
https://doi.org/10.1002/1878-0261.13427/v2/response1
https://doi.org/10.1002/1878-0261.13427/v2/response1