Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Brian J. Glassner"'
Autor:
Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M. Meyers, Jordan G. Bryan, Neekesh V. Dharia, Paul J. Hengeveld, Johanna B. Brüggenthies, Huihui Tang, Andrew J. Aguirre, Quinlan L. Sievers, Benjamin L. Ebert, Brian J. Glassner, Christopher J. Ott, James E. Bradner, Nicholas P. Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J. Keats, Richard W. J. Groen, Nathanael S. Gray, Aedin C. Culhane, James M. McFarland, Joshua M. Dempster, Jonathan D. Licht, Lawrence H. Boise, William C. Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S. Mitsiades
Publikováno v:
de Matos Simoes, R, Shirasaki, R, Downey-Kopyscinski, S L, Matthews, G M, Barwick, B G, Gupta, V A, Dupéré-Richer, D, Yamano, S, Hu, Y, Sheffer, M, Dhimolea, E, Dashevsky, O, Gandolfi, S, Ishiguro, K, Meyers, R M, Bryan, J G, Dharia, N V, Hengeveld, P J, Brüggenthies, J B, Tang, H, Aguirre, A J, Sievers, Q L, Ebert, B L, Glassner, B J, Ott, C J, Bradner, J E, Kwiatkowski, N P, Auclair, D, Levy, J, Keats, J J, Groen, R W J, Gray, N S, Culhane, A C, McFarland, J M, Dempster, J M, Licht, J D, Boise, L H, Hahn, W C, Vazquez, F, Tsherniak, A & Mitsiades, C S 2023, ' Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias ', Nature Cancer, vol. 4, no. 5, pp. 754-773 . https://doi.org/10.1038/s43018-023-00550-x
Nature Cancer, 4(5), 754-773. Nature Research
Nature Cancer, 4(5), 754-773. Nature Research
Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents targe
Autor:
Dhvanir Kansara, Eugen Dhimolea, Pallavi Awate, Alana L. Welm, Jordan Bryan, Brian J. Glassner, Zhiyi Liu, Shruti Sharma, Juliette Bouyssou, Rinath Jeselsohn, Aziz Al'Khafaji, Huihui Tang, Myles Brown, Nathanael S. Gray, Joseline Raja, Boris Bartholdy, Cihangir Duy, Aedín C. Culhane, Yu Chen, Xiang Weng, Ricardo De Matos Simoes, Jennifer Roth, Irene Georgakoudi, Dong Gao, Constantine S. Mitsiades, Ari Melnick, Ryosuke Shirasaki, Aviad Tsherniak, Francisca Vazquez, Michal Scheffer, Samantha Bender
Publikováno v:
Cancer Cell
Treatment-persistent residual tumors impede curative cancer therapy. To understand this cancer cell state we generate models of treatment persistence that simulate the residual tumors. We observe that treatment-persistent tumor cells in organoids, xe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27960f6b5655eb355223383013aae78c
https://europepmc.org/articles/PMC8670073/
https://europepmc.org/articles/PMC8670073/
Autor:
Constantine S. Mitsiades, Joshua M. Dempster, Lawrence H. Boise, Aedín C. Culhane, Sondra L. Downey-Kopyscinski, Jonathan D. Licht, Hu Yiguo, Quinlan L. Sievers, William C. Hahn, Johanna Brueggenthies, John G. Doench, Christopher J. Ott, Geoffrey M. Matthews, Jordan Bryan, Jonathan J Keats, Francisca Vazquez, Joan Levy, Sara Gandolfi, Ricardo De Matos Simoes, Benjamin L. Ebert, Aviad Tsherniak, Huihui Tang, Daniel Auclair, Robin M. Meyers, Olga Dashevsky, Megan Bariteau, Ryosuke Shirasaki, Richard W.J. Groen, James M. McFarland, Minasri Borah, Brian J. Glassner, Nathanael S. Gray, Nicholas Kwiatkowski, Michal Sheffer, Eugen Dhimolea
Publikováno v:
Simoes, R D M, Shirasaki, R, Downey-Kopyscinski, S L, Matthews, G, Yiguo, H, Sheffer, M, Dhimolea, E, Dashevsky, O, Gandolfi, S, Dempster, J, Meyers, R M, Bryan, J, McFarland, J M, Brueggenthies, J, Tang, H, Bariteau, M, Borah, M, Sievers, Q L, Ebert, B, Glassner, B, Ott, C J, Kwiatkowski, N P, Doench, J G, Auclair, D, Levy, J, Boise, L H, Keats, J J, Licht, J D, Groen, R, Gray, N, Culhane, A, Hahn, W C, Vazquez, F, Tsherniak, A & Mitsiades, C S 2019, ' Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias-Implications for the Biology and Therapeutic Targeting of Myeloma ', Blood, vol. 134 . https://doi.org/10.1182/blood-2019-130901
Blood, 134. American Society of Hematology
Blood, 134. American Society of Hematology
In the last 2 decades, the improved clinical outcomes for multiple myeloma (MM) patients have been driven predominantly by therapeutics which exhibit limited activity outside plasma cell (PC) dyscrasias; do not target specific oncogenic mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5c565d67e6f143da1ca00b515db1ad
https://research.vumc.nl/en/publications/5fb40b9b-df16-4a02-bb0a-8f5a34dd6eb4
https://research.vumc.nl/en/publications/5fb40b9b-df16-4a02-bb0a-8f5a34dd6eb4
Autor:
Paul G. Richardson, Benjamin L. Ebert, Constantine S. Mitsiades, Sondra L. Downey-Kopyscinski, Quinlan L. Sievers, Jacob P. Laubach, Eugen Dhimolea, Aedín C. Culhane, Joseline Raja, Olga Dashevsky, Geoffrey M. Matthews, Lawrence H. Boise, Eric S. Fischer, Megan Bariteau, Francisca Vazquez, Ricardo De Matos Simoes, Jonathan D. Licht, James E. Bradner, Michal Sheffer, Huihui Tang, Robert L. Schlossman, Tinghu Zhang, Christopher J. Ott, Nathanael S. Gray, Daniel Auclair, Aviad Tsherniak, Richard W.J. Groen, Ryosuke Shirasaki, Nicholas Kwiatkowski, Sara Gandolfi, Dennis L. Buckley, William C. Hahn, Paul J. Hengeveld, Haley Poarch, Brian J. Glassner, Joan Levy, Jonathan J Keats
Publikováno v:
Shirasaki, R, Gandolfi, S, Simoes, R D M, Matthews, G M, Buckley, D, Raja, J, Sievers, Q L, Dashevsky, O, Poarch, H, Tang, H, Bariteau, M, Sheffer, M, Downey-Kopyscinski, S L, Hengeveld, P, Glassner, B, Dhimolea, E, Ott, C J, Zhang, T, Kwiatkowski, N P, Laubach, J P, Schlossman, R L, Richardson, P G, Culhane, A, Groen, R W J, Fischer, E, Ebert, B L, Vazquez, F, Tsherniak, A, Hahn, W C, Levy, J, Auclair, D, Licht, J D, Keats, J J, Boise, L H, Bradner, J, Gray, N & Mitsiades, C S 2019, ' Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins ', Blood, vol. 134 . https://doi.org/10.1182/blood-2019-130549
Blood, 134. American Society of Hematology
Blood, 134. American Society of Hematology
The discovery that thalidomide derivatives recruit the E3 ligase CRBN to induce neomorphic degradation of proteins critical for multiple myeloma (MM) cells stimulated the research into proteolysis-targeting chimeric compounds (PROTACs), led to develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010396339ca0ccc2d1148ed6135544fb
https://research.vumc.nl/en/publications/a262da2f-f489-473e-b090-d72e765547f7
https://research.vumc.nl/en/publications/a262da2f-f489-473e-b090-d72e765547f7
Autor:
Aedín C. Culhane, Daniel Auclair, Huihui Tang, Brian J. Glassner, Lawrence H. Boise, Ryosuke Shirasaki, Olga Dashevsky, Francisca Vazquez, Sara Gandolfi, Aviad Tsherniak, Benjamin G. Barwick, Ricardo De Matos Simoes, Richard W.J. Groen, Constantine S. Mitsiades, Jonathan D. Licht
Publikováno v:
Blood. 138:1589-1589
For many genes that are recurrently mutated in patient-derived samples or cell lines from multiple myeloma (MM), the functional roles of these genes have remained incompletely understood. We have sought to address the functional implications of these
Autor:
Constantine S. Mitsiades, Eugen Dhimolea, Dhvanir Kansara, Aviad Tsherniak, Jonathan D. Licht, Benjamin G. Barwick, Sondra L. Downey-Kopyscinski, Huihui Tang, Michal Sheffer, Ricardo De Matos Simoes, Shizuka Yamano, Megan Bariteau, Vikas Gupta, Sara Gandolfi, Jeffrey Sorrell, Lawrence H. Boise, Francisca Vazquez, Ryosuke Shirasaki, Aedín C. Culhane, Brian J. Glassner, Olga Dashevsky
Publikováno v:
Blood. 136:18-19
Background: Functional genomics studies based on CRISPR and shRNA have documented that multiple myeloma (MM) cells are preferentially dependent (compared to other neoplasias) on a series of TFs, including IKZF1 and IKZF3 (which are targeted by thalid
Autor:
Lawrence H. Boise, Ryosuke Shirasaki, Ricardo De Matos Simoes, Constantine S. Mitsiades, Francisca Vazquez, Aviad Tsherniak, Shizuka Yamano, Vikas Gupta, Brian J. Glassner, Sondra L. Downey-Kopyscinski, Huihui Tang, Jonathan D. Licht
Publikováno v:
Blood. 136:3-4
Background: Endoplasmic reticulum (ER)-associated degradation (ERAD) for unfolded proteins represents an important biological vulnerability for multiple myeloma (MM) cells, given the high proteostatic stress in these cells due to immunoglobulin secre
Autor:
Jonathan D. Licht, Francisca Vazquez, Daniel Auclair, Constantine S. Mitsiades, Aviad Tsherniak, Ryosuke Shirasaki, Richard W.J. Groen, Joan Levy, Huihui Tang, Olga Dashevsky, William C. Hahn, Ricardo De Matos Simoes, Sara Gandolfi, Aedín C. Culhane, Brian J. Glassner, Megan Bariteau, Michal Sheffer, Eugen Dhimolea
Publikováno v:
Simoes, R D M, Shirasaki, R, Tang, H, Sheffer, M, Dashevsky, O, Gandolfi, S, Dhimolea, E, Bariteau, M, Licht, J D, Glassner, B, Groen, R W J, Levy, J, Auclair, D, Vazquez, F, Tsherniak, A, Hahn, W C, Culhane, A & Mitsiades, C S 2018, ' Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma ', Blood, vol. 132 . https://doi.org/10.1182/blood-2018-189
Blood, 132. American Society of Hematology
Blood, 132. American Society of Hematology
During the last two decades, cell lines and patient-derived samples from multiple myeloma (MM) have been extensively profiled for alterations in their genome with the anticipation that those genes with the most recurrent lesions could represent attra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f089435de57728af48bd1848b551b7
https://research.vumc.nl/en/publications/a1a08e32-d235-4817-b3c1-98c2dc6dfbd4
https://research.vumc.nl/en/publications/a1a08e32-d235-4817-b3c1-98c2dc6dfbd4
Autor:
Dennis L. Buckley, Aviad Tsherniak, Nicholas Kwiatkowski, Ryosuke Shirasaki, Jonathan J Keats, William C. Hahn, Paul J. Hengeveld, Haley Poarch, James E. Bradner, Aedín C. Culhane, Joan Levy, Jacob P. Laubach, Huihui Tang, Geoffrey M. Matthews, Megan Bariteau, Yiguo Hu, Lawrence H. Boise, Paul G. Richardson, Eric S. Fischer, Jonathan D. Licht, Quinlan L. Sievers, Ricardo De Matos Simoes, Tinghu Zhang, Brian J. Glassner, Francisca Vazquez, Johanna Bruggenthies, Constantine S. Mitsiades, Robert L. Schlossman, Daniel Auclair, Richard W.J. Groen, Sondra L. Downey-Kopyscinski, Nathanael S. Gray, Sara Gandolfi, Benjamin L. Ebert, Olga Dashevsky, Christopher J. Ott, Joseline Raja Vora, Michal Sheffer, Eugen Dhimolea
Publikováno v:
Cell Rep
Cell Reports, 34(1):108532. Cell Press
Shirasaki, R, Matthews, G M, Gandolfi, S, de Matos Simoes, R, Buckley, D L, Raja Vora, J, Sievers, Q L, Brüggenthies, J B, Dashevsky, O, Poarch, H, Tang, H, Bariteau, M A, Sheffer, M, Hu, Y, Downey-Kopyscinski, S L, Hengeveld, P J, Glassner, B J, Dhimolea, E, Ott, C J, Zhang, T, Kwiatkowski, N P, Laubach, J P, Schlossman, R L, Richardson, P G, Culhane, A C, Groen, R W J, Fischer, E S, Vazquez, F, Tsherniak, A, Hahn, W C, Levy, J, Auclair, D, Licht, J D, Keats, J J, Boise, L H, Ebert, B L, Bradner, J E, Gray, N S & Mitsiades, C S 2021, ' Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins ', Cell Reports, vol. 34, no. 1, 108532 . https://doi.org/10.1016/j.celrep.2020.108532
Cell Reports, 34(1):108532. Cell Press
Shirasaki, R, Matthews, G M, Gandolfi, S, de Matos Simoes, R, Buckley, D L, Raja Vora, J, Sievers, Q L, Brüggenthies, J B, Dashevsky, O, Poarch, H, Tang, H, Bariteau, M A, Sheffer, M, Hu, Y, Downey-Kopyscinski, S L, Hengeveld, P J, Glassner, B J, Dhimolea, E, Ott, C J, Zhang, T, Kwiatkowski, N P, Laubach, J P, Schlossman, R L, Richardson, P G, Culhane, A C, Groen, R W J, Fischer, E S, Vazquez, F, Tsherniak, A, Hahn, W C, Levy, J, Auclair, D, Licht, J D, Keats, J J, Boise, L H, Ebert, B L, Bradner, J E, Gray, N S & Mitsiades, C S 2021, ' Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins ', Cell Reports, vol. 34, no. 1, 108532 . https://doi.org/10.1016/j.celrep.2020.108532
Heterobifunctional proteolysis-targeting chimeric compounds leverage the activity of E3 ligases to induce degradation of target oncoproteins and exhibit potent preclinical antitumor activity. To dissect the mechanisms regulating tumor cell sensitivit
Autor:
Huihui Tang, Eugen Dhimolea, Lawrence H. Boise, Megan Bariteau, Ricardo De Matos Simoes, John G. Doench, Jonathan D. Licht, Olga Dashevsky, Jeffrey Sorrell, Aviad Tsherniak, Constantine S. Mitsiades, Sondra L. Downey-Kopyscinski, Michal Sheffer, Brian J. Glassner, Francisca Vazquez, Ryosuke Shirasaki, Aedín C. Culhane, William C. Hahn, Sara Gandolfi
Publikováno v:
Blood. 136:36-36
Background: CRISPR-based functional genomics studies in pooled format are increasingly used to define the mechanisms of tumor cells resistance to diverse therapies. Despite many advantages of CRISPR compared to prior functional genomics methodologies