Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Brian J. Dewar"'
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64309 (2013)
The metastasis-associated tyrosine phosphatase PRL-3/PTP4A is upregulated in numerous cancers, but the mechanisms modulating PRL-3 activity other than its expression levels have not been investigated. Here we report evidence for both Src-dependent ty
Externí odkaz:
https://doaj.org/article/de0d87d46b4c4d9b94ed868aedee517d
Autor:
Matthew J Cooper, Nathan J Cox, Eric I Zimmerman, Brian J Dewar, James S Duncan, Martin C Whittle, Thien A Nguyen, Lauren S Jones, Sreerupa Ghose Roy, David M Smalley, Pei Fen Kuan, Kristy L Richards, Richard I Christopherson, Jian Jin, Stephen V Frye, Gary L Johnson, Albert S Baldwin, Lee M Graves
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66755 (2013)
Protein kinases play key roles in oncogenic signaling and are a major focus in the development of targeted cancer therapies. Imatinib, a BCR-Abl tyrosine kinase inhibitor, is a successful front-line treatment for chronic myelogenous leukemia (CML). H
Externí odkaz:
https://doaj.org/article/5e341c4d37844eceabaaf81238a3ae18
Autor:
Michael S. Eaton, Hanna E. Foster, Jonathan W. Lowery, Stephen R. Shively, Justin Nathan, Aaron Broege, Taylor D. Ward, Hannah M. Davis, Maggie M. Plattes, Brian J. Dewar, Jon W. Arthur, Nicholas Weinstein, Lilian I. Plotkin, Eric M. Wauson, Ryann Shor, Jordan B. Newby
Publikováno v:
Journal of Physiology and Biochemistry. 74:3-8
The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such as L-glycine and L-gluta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f246954e79ba4e01bbbf12e4787f2e6b
https://doi.org/10.1007/s13105-017-0596-7
https://doi.org/10.1007/s13105-017-0596-7
Autor:
Lee M. Graves, Nathan J. Cox, Brian J. Dewar, Katherine Tech, Ekhson Holmuhamedov, Michael P. East, Denis O. Okumu, Ian M. McDonald, Lucas J. Aponte-Collazo, Jeffrey M. Macdonald, Andrey P. Tikunov
Publikováno v:
Biochim Biophys Acta Gen Subj
BACKGROUND: Imatinib mesylate (imatinib) is the first-line treatment for newly diagnosed chronic myeloid leukemia (CML) due to its remarkable hematologic and cytogenetic responses. We previously demonstrated that the imatinib-resistant CML cells (Myl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7b93e95c12b2a9fc935307d890d5c6
https://doi.org/10.1016/j.bbagen.2019.129507
https://doi.org/10.1016/j.bbagen.2019.129507
Autor:
Lee M. Graves, Richard M. Allen, Dmitriy Gremyachinskiy, Klaus M. Hahn, Steven M. Lewis, Brian Kuhlman, Timothy C. Elston, Brian J. Dewar, Brian K. Kay, Akash Gulyani, Jianrong Wu, Eric A. Vitriol
Publikováno v:
Nature chemical biology
Fluorescent biosensors for living cells currently require laborious optimization and a unique design for each target. They are limited by the availability of naturally occurring ligands with appropriate target specificity. Here we describe a biosenso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cdb6933eceee100a29cc3d9fd075f9
https://doi.org/10.1038/nchembio.585
https://doi.org/10.1038/nchembio.585
Publikováno v:
Journal of Biological Chemistry. 278:46261-46269
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that function as ligand-activated transcription factors regulating lipid metabolism and homeostasis. In addition to their ability to regulate PPAR-mediated gene transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aefa5cef28afbd5969727d949ee5967
https://doi.org/10.1074/jbc.m307827200
https://doi.org/10.1074/jbc.m307827200
Nicotine Increases Hepatic Oxygen Uptake in the Isolated Perfused Rat Liver by Inhibiting Glycolysis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 301:930-937
Nicotine influences energy metabolism, yet mechanisms remain unclear. Since the liver is one of the largest organs and performs many metabolic functions, the goal of this study was to determine whether nicotine would affect respiration and other meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe3d2d6c509e834988328599ebb20ee
https://doi.org/10.1124/jpet.301.3.930
https://doi.org/10.1124/jpet.301.3.930
Autor:
Jian Jin, David M. Smalley, Albert S. Baldwin, Sreerupa Ghose Roy, Matthew J. Cooper, Thien Nguyen, James S. Duncan, Richard I. Christopherson, Gary L. Johnson, Nathan J. Cox, Brian J. Dewar, Lee M. Graves, Stephen V. Frye, Lauren S. Jones, Pei Fen Kuan, Eric I. Zimmerman, Martin C. Whittle, Kristy L. Richards
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e66755 (2013)
PLoS ONE, Vol 8, Iss 6, p e66755 (2013)
Protein kinases play key roles in oncogenic signaling and are a major focus in the development of targeted cancer therapies. Imatinib, a BCR-Abl tyrosine kinase inhibitor, is a successful front-line treatment for chronic myelogenous leukemia (CML). H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee09a4cba4c9d0e19b1c5018dbbb8ab
http://europepmc.org/articles/PMC3691232
http://europepmc.org/articles/PMC3691232
Autor:
Rex E. Jeffries, Daniel B. Vigneron, Abigail Todd, Justyna E. Wolak, Peter Pediatitakis, Brian J. Dewar, Jason H. Winnike, Timothy C. Elston, Kayvan Rahimi-Keshari, Ekhson Holmuhamedov, M. P. Joy, Lee M. Graves, Jeffrey M. Macdonald, John Kurhanewicz, Oleg V. Favorov
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781617796173
Metabolism is an interconnectingnetwork ofmetabolite consumption and creation.Metabolomics has focused onmetabolite concentrations inmetabolic networks. Fluxomics is also required in the study ofmetabolism and quantifies the fluxof substrate through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df811abfd727e0e0b59a5694157df0bb
https://doi.org/10.1007/978-1-61779-618-0_11
https://doi.org/10.1007/978-1-61779-618-0_11
Autor:
Carl J. Mousley, Kyle D. Trettin, Vytas A. Bankaitis, Max Wolpert, Aaron H. Nile, Peihua Yuan, Stephen J. Deminoff, Jeffrey M. Macdonald, Alan G. Hinnebusch, Brian J. Dewar, Naseem A. Gaur, Paul K. Herman
Publikováno v:
Cell. 148(4)
Kes1, and other oxysterol binding protein (OSBP) superfamily members, are involved in membrane and lipid trafficking through trans-Golgi network (TGN) and endosomal systems. We demonstrate that Kes1 represents a sterol-regulated antagonist of TGN/end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d61948d6bcf4fcc9702b62753595979
https://pubmed.ncbi.nlm.nih.gov/22341443
https://pubmed.ncbi.nlm.nih.gov/22341443