Výsledky vyhledávání - "Brian J. Booth"

RNA Editing: Expanding the Potential of RNA Therapeutics

Autor: Brian J. Booth, Sami Nourreddine, Dhruva Katrekar, Yiannis Savva, Debojit Bose, Thomas J. Long, David J. Huss, Prashant Mali

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy, vol 31, iss 6

RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic. In addition, RNA-targeting drugs have been developed for diseases with significa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add28cc82cd74a80d722ec08d3f334e7
https://pubmed.ncbi.nlm.nih.gov/36620962

Zobrazit plný text záznamu

Extending human IgG half-life using structure-guided design

Autor: Zachary Shriver, Brian J. Booth, Boopathy Ramakrishnan, Kristin Narayan, Karthik Viswanathan, Andrew M. Wollacott, Gregory J. Babcock

Publikováno v: mAbs

Engineering of antibodies for improved pharmacokinetics through enhanced binding to the neonatal Fc receptor (FcRn) has been demonstrated in transgenic mice, non-human primates and humans. Traditionally, such approaches have largely relied on random

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6720c28be0a5739f2027ecb1e0378c
http://europepmc.org/articles/PMC6204840

Zobrazit plný text záznamu

Identification of a Human Monoclonal Antibody To Replace Equine Diphtheria Antitoxin for Treatment of Diphtheria Intoxication

Autor: William D. Thomas, Brett Leav, Yang Wang, Susan Sloan, Kirk J. Rowley, Peter S. Cheslock, Leila M. Sevigny, Kerry A. Garrity, Brian J. Booth, Gregory J. Babcock

Publikováno v: Infection and Immunity. 81:3992-4000

Diphtheria antitoxin (DAT) has been the cornerstone of the treatment of Corynebacterium diphtheriae infection for more than 100 years. Although the global incidence of diphtheria has declined steadily over the last quarter of the 20th century, the di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeddc7ee9bff23c28eeabf8c5371d87b
https://doi.org/10.1128/iai.00462-13

Zobrazit plný text záznamu

G glycoprotein amino acid residues required for human monoclonal antibody RAB1 neutralization are conserved in rabies virus street isolates

Autor: Gregory J. Babcock, Brian J. Booth, Yang Wang, Susan Sloan, Kirk J. Rowley, Donna M. Ambrosino

Publikováno v: Antiviral Research. 91:187-194

Replacement of polyclonal anti-rabies immunoglobulin (RIG) used in rabies post-exposure prophylaxis (PEP) with a monoclonal antibody will eliminate cost and availability constraints that currently exist using RIG in the developing world. The human mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da74ca0de77390aca69a48af4cf792ef
https://doi.org/10.1016/j.antiviral.2011.06.002

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání