Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Brian J. Bender"'
Autor:
Nina G. Bozhanova, Joel M. Harp, Brian J. Bender, Alexey S. Gavrikov, Dmitry A. Gorbachev, Mikhail S. Baranov, Christina B. Mercado, Xuan Zhang, Konstantin A. Lukyanov, Alexander S. Mishin, Jens Meiler
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11 (2021)
The use of unnatural fluorogenic molecules widely expands the pallet of available genetically encoded fluorescent imaging tools through the design of fluorogen activating proteins (FAPs). While there is already a handful of such probes available, eac
Externí odkaz:
https://doaj.org/article/826bc1b7f0f148b8ad96f37c2d2ca4db
Autor:
Peter Schmidt, Brian J. Bender, Anette Kaiser, Khushboo Gulati, Holger A. Scheidt, Heidi E. Hamm, Jens Meiler, Annette G. Beck-Sickinger, Daniel Huster
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2018)
Prerequisite for structural studies on G protein-coupled receptors is the preparation of highly concentrated, stable, and biologically active receptor samples in milligram amounts of protein. Here, we present an improved protocol for Escherichia coli
Externí odkaz:
https://doaj.org/article/42d6f94ad3484c93916a544075ea711c
Autor:
Samuel T. Slocum, Yongfeng Liu, Bryan L. Roth, Jian Jin, Brian E. Krumm, Brian J. Bender, Reid H.J. Olsen, Hye Jin Kang, Justin G. English, Isha Singh, Jing Liu, Lily Yeh Jan, Wenlei Ye, Brian K. Shoichet, Xi Ping Huang, Byron W. Hayes, Can Cao, John D. McCorvy, Jonathan F. Fay, Katherine Lansu, Soman N. Abraham, Shicheng Zhang, Chengwei Zhang, Wesley K. Kroeze, Kuglae Kim, He Chen, Ryan H. Gumpper, Jeffrey F. DiBerto, Joel Karpiak
Publikováno v:
Nature
Nature, vol 600, iss 7887
Nature, vol 600, iss 7887
The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently1. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e74bb609d8bd744fc782cf9ab54a3d
https://doi.org/10.1038/s41586-021-04126-6
https://doi.org/10.1038/s41586-021-04126-6
Autor:
Elleansar Okwei, Shannon T. Smith, Brian J. Bender, Brittany Allison, Soumya Ganguly, Alexander Geanes, Xuan Zhang, Kaitlyn Ledwitch, Jens Meiler
Fragment-based drug discovery begins with the identification of small molecules with a molecular weight of usually less than 250 Da that weakly bind to the protein of interest. This technique is challenging for computational docking methods as bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4397c52a796ea3b0fb1d5dda06cf905
https://doi.org/10.1101/2022.10.18.512794
https://doi.org/10.1101/2022.10.18.512794
Publikováno v:
Biochem Biophys Res Commun
Chemokine receptors are a subset of G protein-coupled receptors defined by the distinct property of binding small protein ligands in the chemokine family. Chemokine receptors recognize their ligands by a mechanism that is distinct from other class A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d797d8fd80ab6774e67c642533c0499b
https://doi.org/10.1016/j.bbrc.2019.12.076
https://doi.org/10.1016/j.bbrc.2019.12.076
Autor:
Jens Meiler, Konstantin A. Lukyanov, Mikhail S. Baranov, Nina G. Bozhanova, Christina B. Mercado, Brian J. Bender, Dmitry A. Gorbachev, Xuan Zhang, Alexey S. Gavrikov, Alexander S. Mishin, Joel M. Harp
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 11, p e1009555 (2021)
PLoS Computational Biology, Vol 17, Iss 11 (2021)
PLoS Computational Biology, Vol 17, Iss 11, p e1009555 (2021)
PLoS Computational Biology, Vol 17, Iss 11 (2021)
The use of unnatural fluorogenic molecules widely expands the pallet of available genetically encoded fluorescent imaging tools through the design of fluorogen activating proteins (FAPs). While there is already a handful of such probes available, eac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b31c58ce78fbf10509c5d88969b32b3
http://europepmc.org/articles/PMC8601599
http://europepmc.org/articles/PMC8601599
Autor:
John J. Irwin, Stefan Gahbauer, Brian K. Shoichet, Elissa A Fink, Andreas Luttens, Chase M Webb, Jens Carlsson, Trent E. Balius, Reed M. Stein, Jiankun Lyu, Brian J. Bender
Publikováno v:
Nature protocols, vol 16, iss 10
Nature Protocols
Nat Protoc
Nature Protocols
Nat Protoc
Structure-based docking screens of large compound libraries have become common in early drug and probe discovery. As computer efficiency has improved and compound libraries have grown, the ability to screen hundreds of millions, and even billions, of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a64d6d4f3dbd3694374d6452f510ec
https://escholarship.org/uc/item/9hs932s0
https://escholarship.org/uc/item/9hs932s0
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 10, p e1007597 (2020)
PLoS Computational Biology, Vol 16, Iss 10, p e1007597 (2020)
As sequencing methodologies continue to advance, the availability of protein sequences far outpaces the ability of structure determination. Homology modeling is used to bridge this gap but relies on high-identity templates for accurate model building
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b897b4adda6685d21dcba15ed19f32
http://europepmc.org/articles/PMC7652349
http://europepmc.org/articles/PMC7652349
G-protein coupled receptors (GPCRs) represent a significant target class for pharmaceutical therapies. However, to date, only about 10% of druggable GPCRs have had their structures characterized at atomic resolution. Further, because of the flexibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3179ccd20ca95ef5d41fefef239edcf
https://doi.org/10.1101/2019.12.13.875237
https://doi.org/10.1101/2019.12.13.875237
Autor:
Guenther Bernhardt, Peter Schmidt, David Wifling, Bo Xu, Kerstin Burkert, Qiang Zhao, Cuiying Yi, Max Keller, Rongguang Zhang, Raymond C. Stevens, Beibei Li, Daniel Huster, Beili Wu, Timo Littmann, Anette Kaiser, Shuo Han, Lisa Maria Kögler, Mathias Bosse, Armin Buschauer, Sheng Ye, Jens Meiler, Dan Larhammar, Nicole Plank, Zhenlin Yang, Annette G. Beck-Sickinger, Brian J. Bender
Publikováno v:
Nature
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology(1,2). The NPY-Y receptor system has emerged as one of the most complex networks with three peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c7c85e188410a47148a2b5ceedc71f
https://doi.org/10.1038/s41586-018-0046-x
https://doi.org/10.1038/s41586-018-0046-x