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of 48
pro vyhledávání: '"Brian J. Aneskievich"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 11943 (2023)
The overactivity of keratinocyte cytoplasmic signaling contributes to several cutaneous inflammatory and immune pathologies. An important emerging complement to proteins responsible for this overactivity is signal repression brought about by several
Externí odkaz:
https://doaj.org/article/876ab41d72c54e868d477ceea9057575
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14323 (2022)
Intrinsically disordered proteins (IDPs) move through an ensemble of conformations which allows multitudinous roles within a cell. Keratinocytes, the predominant cell type in mammalian epidermis, have had only a few individual proteins assessed for i
Externí odkaz:
https://doaj.org/article/c29c494bc4d74c5880fb0d15469c3ff7
Publikováno v:
Mediators of Inflammation, Vol 2020 (2020)
TNIP1 protein is a widely expressed, cytoplasmic inhibitor of inflammatory signaling initiated by membrane receptors such as TLRs which recognize pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). Keratinocyte TNIP1 defic
Externí odkaz:
https://doaj.org/article/10692e7b1d41472d80d0812628193803
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7912 (2021)
Epidermal keratinocyte proteins include many with an eccentric amino acid content (compositional bias), atypical ultrastructural fate (built-in protease sensitivity), or assembly visible at the light microscope level (cytoplasmic granules). However,
Externí odkaz:
https://doaj.org/article/1d90dfc6e86b499ebe1fd2a23e05e6d8
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1531 (2020)
TNFAIP3 interacting protein 1 (TNIP1) interacts with numerous non-related cellular, viral, and bacterial proteins. TNIP1 is also linked with multiple chronic inflammatory disorders on the gene and protein levels, through numerous single-nucleotide po
Externí odkaz:
https://doaj.org/article/682f918397164af18a2f91372862df90
Autor:
Rambon Shamilov, Brian J. Aneskievich
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
TNIP1 protein is increasingly being recognized as a key repressor of inflammatory signaling and a potential factor in multiple autoimmune diseases. In addition to earlier foundational reports of TNIP1 SNPs in human autoimmune diseases and TNIP1 prote
Externí odkaz:
https://doaj.org/article/cb4ff392c9434c9fb322509a703a58ad
Publikováno v:
Mediators of Inflammation, Vol 2020 (2020)
Mediators of Inflammation
Mediators of Inflammation
TNIP1 protein is a widely expressed, cytoplasmic inhibitor of inflammatory signaling initiated by membrane receptors such as TLRs which recognize pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). Keratinocyte TNIP1 defic
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7912, p 7912 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Epidermal keratinocyte proteins include many with an eccentric amino acid content (compositional bias), atypical ultrastructural fate (built-in protease sensitivity), or assembly visible at the light microscope level (cytoplasmic granules). However,
Publikováno v:
Progress in Molecular Biology and Translational Science ISBN: 9780323852999
The well-defined roles and specific protein-protein interactions of many integral membrane proteins (IMPs), such as those functioning as receptors for extracellular matrix proteins and soluble growth factors, easily align with considering IMP structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de84e5bff2fa4a6fa12d21b0a220e2d2
https://doi.org/10.1016/bs.pmbts.2021.06.002
https://doi.org/10.1016/bs.pmbts.2021.06.002
Autor:
Brian J. Aneskievich, Rudi Beyaert, Sarah L. Gaffen, Lawrence P. Kane, Nilesh Amatya, Erin E. Childs, Abhishek V. Garg, J. Agustin Cruz, Averil Ma
Publikováno v:
IMMUNOHORIZONS
IL-17 activates NF-κB and induces expression of proinflammatory genes. IL-17 drives disease in autoimmune conditions, and anti–IL-17 Abs have shown impressive success in the clinic. Although produced by lymphocytes, IL-17 predominantly signals in