The prognostic effect of mechanical, ultrastructural, and ECM signatures in glioblastoma core and rim

Autor: Bradley J. Mahaffey, Zachary P. Fowler, Zoe Lung, Vivien Dang, Hyunchul Lee, Allison McKenzie Johnson, Marco A. Munoz, Dylan A. Goodin, Hermann B. Frieboes, Brian J. Williams, Joseph Chen

Publikováno v: APL Bioengineering, Vol 8, Iss 3, Pp 036101-036101-9 (2024)

Glioblastoma (GBM) is a highly invasive, aggressive brain cancer that carries a median survival of 15 months and is resistant to standard therapeutics. Recent studies have demonstrated that intratumoral heterogeneity plays a critical role in promotin

Externí odkaz: https://doaj.org/article/c2ae37e75d8844f780bc3b243f57de78

Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma.

Autor: Dae-Hee Lee, Ying Zhang, Amin B Kassam, Myung-Jin Park, Paul Gardner, Daniel Prevedello, Stephanie Henry, Craig Horbinski, Jan H Beumer, Hussein Tawbi, Brian J Williams, Mark E Shaffrey, Merrill J Egorin, Roger Abounader, Deric M Park

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134426 (2015)

The majority of chordomas show activation of the platelet-derived growth factor receptor (PDGFR). Based on in vitro intertumoral variation in response to recombinant PDGF protein and PDGFR inhibition, and variable tumor response to imatinib, we hypot

Externí odkaz: https://doaj.org/article/b9e40afa3cfc436788788ef2f5fd5a4d

XRISM Spectroscopy of the Fe Kα Emission Line in the Seyfert Active Galactic Nucleus NGC 4151 Reveals the Disk, Broad-line Region, and Torus

Autor: XRISM Collaboration, Marc Audard, Hisamitsu Awaki, Ralf Ballhausen, Aya Bamba, Ehud Behar, Rozenn Boissay-Malaquin, Laura Brenneman, Gregory V. Brown, Lia Corrales, Elisa Costantini, Renata Cumbee, Maria Diaz Trigo, Chris Done, Tadayasu Dotani, Ken Ebisawa, Megan E. Eckart, Dominique Eckert, Teruaki Enoto, Satoshi Eguchi, Yuichiro Ezoe, Adam Foster, Ryuichi Fujimoto, Yutaka Fujita, Yasushi Fukazawa, Kotaro Fukushima, Akihiro Furuzawa, Luigi Gallo, Javier A. García, Liyi Gu, Matteo Guainazzi, Kouichi Hagino, Kenji Hamaguchi, Isamu Hatsukade, Katsuhiro Hayashi, Takayuki Hayashi, Natalie Hell, Edmund Hodges-Kluck, Ann Hornschemeier, Yuto Ichinohe, Manabu Ishida, Kumi Ishikawa, Yoshitaka Ishisaki, Jelle Kaastra, Timothy Kallman, Erin Kara, Satoru Katsuda, Yoshiaki Kanemaru, Richard Kelley, Caroline Kilbourne, Shunji Kitamoto, Shogo Kobayashi, Takayoshi Kohmura, Aya Kubota, Maurice Leutenegger, Michael Loewenstein, Yoshitomo Maeda, Maxim Markevitch, Hironori Matsumoto, Kyoko Matsushita, Dan McCammon, Brian McNamara, François Mernier, Eric D. Miller, Jon M. Miller, Ikuyuki Mitsuishi, Misaki Mizumoto, Tsunefumi Mizuno, Koji Mori, Koji Mukai, Hiroshi Murakami, Richard Mushotzky, Hiroshi Nakajima, Kazuhiro Nakazawa, Jan-Uwe Ness, Kumiko Nobukawa, Masayoshi Nobukawa, Hirofumi Noda, Hirokazu Odaka, Shoji Ogawa, Anna Ogorzalek, Takashi Okajima, Naomi Ota, Stephane Paltani, Robert Petre, Paul Plucinsky, Frederick S. Porter, Katja Pottschmidt, Kosuke Sato, Toshiki Sato, Makoto Sawada, Hiromi Seta, Megumi Shidatsu, Aurora Simionescu, Randall Smith, Hiromasa Suzuki, Andrew Szymkowiak, Hiromitsu Takahashi, Mai Takeo, Toru Tamagawa, Keisuke Tamura, Takaaki Tanaka, Atsushi Tanimoto, Makoto Tashiro, Yukikatsu Terada, Yuichi Terashima, Yohko Tsuboi, Masahiro Tsujimoto, Hiroshi Tsunemi, Takeshi Tsuru, Hiroyuki Uchida, Nagomi Uchida, Yuusuke Uchida, Hideki Uchiyama, Yoshihiro Ueda, Shinichiro Uno, Jacco Vink, Shin Watanabe, Brian J. Williams, Satoshi Yamada, Shinya Yamada, Hiroya Yamaguchi, Kazutaka Yamaoka, Noriko Yamasaki, Makoto Yamauchi, Shigeo Yamauchi, Tahir Yaqoob, Tomokage Yoneyama, Tessei Yoshida, Mihoko Yukita, Irina Zhuravleva, Xin Xiang, Takeo Minezaki, Margaret Buhariwalla, Dimitra Gerolymatou, Scott Hagen

Publikováno v: The Astrophysical Journal Letters, Vol 973, Iss 1, p L25 (2024)

We present an analysis of the first two XRISM/Resolve spectra of the well-known Seyfert-1.5 active galactic nucleus (AGN) in NGC 4151, obtained in 2023 December. Our work focuses on the nature of the narrow Fe K _α emission line at 6.4 keV, the stro

Externí odkaz: https://doaj.org/article/5d83f682f7f5495191f4acac34927e55

Acute posterior reversible encephalopathy syndrome (PRES) in setting of interferon-beta use: case presentation with reduction of edema in 72 h after cessation of interferon-beta therapy with sub-clinical inflammation

Autor: Nicholas Dietz, Zarmina Mufti, Muhammed Yousaf, Randal Brown, Christopher Counts, Martin F. Bjurström, Brian J. Williams, David Robertson

Publikováno v: BMC Neurology, Vol 21, Iss 1, Pp 1-5 (2021)

Abstract Background Posterior reversible encephalopathy syndrome (PRES) represents a transient change in mental status with associated vasogenic edema of cortical and subcortical brain structures. It is often attributed to multifactorial etiology inc

Externí odkaz: https://doaj.org/article/f9730d8944384865afd777ad19ebc271

Rapid Expansion of the Young Type Ia Supernova Remnant 0519–69.0: More Evidence for a Circumstellar Shell

Autor: Benson T. Guest, Kazimierz J. Borkowski, Parviz Ghavamian, Robert Petre, Adrien Picquenot, Stephen P. Reynolds, Ivo R. Seitenzahl, Brian J. Williams

Publikováno v: The Astrophysical Journal, Vol 946, Iss 1, p 44 (2023)

The nature of Type Ia supernovae remains controversial. The youngest remnants of Ia supernovae hold clues to the explosion and to the immediate surroundings. We present a third epoch of Chandra observations of the ∼600 yr old Type Ia remnant 0519�

Externí odkaz: https://doaj.org/article/cbdb2bd3a230453ea2e6c161eecdbaad