Zobrazeno 1 - 10
of 973
pro vyhledávání: '"Brian J Smith"'
Autor:
Zheng Yuan, Mark F van Delft, Mark Xiang Li, Fransisca Sumardy, Brian J Smith, David C S Huang, Guillaume Lessene, Yelena Khakam, Ruitao Jin, Sitong He, Nicholas A Smith, Richard W Birkinshaw, Peter E Czabotar, Grant Dewson
Publikováno v:
PLoS Biology, Vol 22, Iss 5, p e3002617 (2024)
BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial channel prote
Externí odkaz:
https://doaj.org/article/91dcfa91babb4571a0a5c987ad54d99d
Autor:
Rukshar Kaizerali Gobarani, Gregory R Weeks, Michael J Dooley, Brian J Smith, Antony Veale, Ashley Webb, Sue Kirsa, Dennis Thomas, Rudi Gasser, Eldho Paul, Jacqueline Parkinson, Darshana Meanger, Lisa Coward, Zoe Kopsaftis, Olivia Rofe, Paula Lee, Johnson George
Publikováno v:
BMJ Open, Vol 10, Iss 10 (2020)
Introduction Smoking is a leading cause of premature deaths globally. The health benefits of smoking cessation are many. However, majority of quit attempts are unsuccessful. One way to potentially improve success rates is to evaluate new combinations
Externí odkaz:
https://doaj.org/article/8a9185db5f654668a360cf6e778641be
Autor:
Kristin V Carson-Chahhoud, Brian J Smith, Matthew J Peters, Malcolm P Brinn, Faisal Ameer, Kuljit Singh, Robert Fitridge, Simon A Koblar, Jim Jannes, Antony J Veale, Sharon Goldsworthy, Khin Hnin, Adrian J Esterman
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231095 (2020)
IntroductionVarenicline tartrate is superior for smoking cessation to other tobacco cessation therapies by 52 weeks, in the outpatient setting. We aimed to evaluate the long-term (104 week) efficacy following a standard course of inpatient-initiated
Externí odkaz:
https://doaj.org/article/f322c3afba7d4a90891e341a53c923b0
Autor:
Peter Ahorukomeye, Maria M Disotuar, Joanna Gajewiak, Santhosh Karanth, Maren Watkins, Samuel D Robinson, Paula Flórez Salcedo, Nicholas A Smith, Brian J Smith, Amnon Schlegel, Briony E Forbes, Baldomero Olivera, Danny Hung-Chieh Chou, Helena Safavi-Hemami
Publikováno v:
eLife, Vol 8 (2019)
The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin th
Externí odkaz:
https://doaj.org/article/71443f02920a4c85a8dd87031b11da69
Autor:
Reinhard R Beichel, Ethan J Ulrich, Brian J Smith, Christian Bauer, Bartley Brown, Thomas Casavant, John J Sunderland, Michael M Graham, John M Buatti
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215465 (2019)
Introduction18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is now a standard diagnostic imaging test performed in patients with head and neck cancer for staging, re-staging, radiotherapy planning, and outcome assessment. Currently,
Externí odkaz:
https://doaj.org/article/93c5774888e3412a8c0d0b9c15ef70df
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166298 (2016)
The reliability of quantitative structure-property relationship (QSPR) and quantitative structure-activity relationship (QSAR) models is often difficult to assess due to the problems of accessing the tools and data used to build the models. We presen
Externí odkaz:
https://doaj.org/article/3e4a6ebc7f944aab926da411163ce2d3
Autor:
Michael J Coffey, Brad E Sleebs, Alessandro D Uboldi, Alexandra Garnham, Magdalena Franco, Nicole D Marino, Michael W Panas, David JP Ferguson, Marta Enciso, Matthew T O'Neill, Sash Lopaticki, Rebecca J Stewart, Grant Dewson, Gordon K Smyth, Brian J Smith, Seth L Masters, John C Boothroyd, Justin A Boddey, Christopher J Tonkin
Publikováno v:
eLife, Vol 4 (2015)
Infection by Toxoplasma gondii leads to massive changes to the host cell. Here, we identify a novel host cell effector export pathway that requires the Golgi-resident aspartyl protease 5 (ASP5). We demonstrate that ASP5 cleaves a highly constrained a
Externí odkaz:
https://doaj.org/article/87c2bb0c16e043169ac8333f604bb8e0
Publikováno v:
International Journal of COPD, Vol 2008, Iss Issue 1, Pp 109-112 (2008)
Melanie Harris1, Brian J Smith2,3, Antony Veale41Department of Medicine, The University of Adelaide, Australia; 2Clinical Epidemiology Unit and Respiratory Medicine and 3Sleep Disorders Unit, The Queen Elizabeth Hospital and Health Services, Adelaide
Externí odkaz:
https://doaj.org/article/f23a5d18c0fd4edea1b41484a951c60e
Autor:
Margaret E Hunter, Sara J Oyler-McCance, Robert M Dorazio, Jennifer A Fike, Brian J Smith, Charles T Hunter, Robert N Reed, Kristen M Hart
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121655 (2015)
Environmental DNA (eDNA) methods are used to detect DNA that is shed into the aquatic environment by cryptic or low density species. Applied in eDNA studies, occupancy models can be used to estimate occurrence and detection probabilities and thereby
Externí odkaz:
https://doaj.org/article/44f20ce0d7e84178a6f2a87b5be20a22
Autor:
Lin Chen, Yibin Xu, Julie Healer, Jenny K Thompson, Brian J Smith, Michael C Lawrence, Alan F Cowman
Publikováno v:
eLife, Vol 3 (2014)
Plasmodium falciparum causes the most severe form of malaria in humans and is responsible for over 700,000 deaths annually. It is an obligate intracellular parasite and invades erythrocytes where it grows in a relatively protected niche. Invasion of
Externí odkaz:
https://doaj.org/article/7cc0aec92d1a401b80fa8cadc4338751