Výsledky vyhledávání - "Brian J Reon"

Akademický článek

Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis.

Autor: Brian J Reon, Jordan Anaya, Ying Zhang, James Mandell, Benjamin Purow, Roger Abounader, Anindya Dutta

Publikováno v: PLoS Medicine, Vol 13, Iss 12, p e1002192 (2016)

BackgroundEach year, over 16,000 patients die from malignant brain cancer in the US. Long noncoding RNAs (lncRNAs) have recently been shown to play critical roles in regulating neurogenesis and brain tumor progression. To better understand the role o

Externí odkaz: https://doaj.org/article/a1e3e0b04b7f4bf8968e275245fa1185

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Akademický článek

A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteins.

Autor: Masamitsu Negishi, Somsakul P Wongpalee, Sukumar Sarkar, Jonghoon Park, Kyung Yong Lee, Yoshiyuki Shibata, Brian J Reon, Roger Abounader, Yutaka Suzuki, Sumio Sugano, Anindya Dutta

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95216 (2014)

Long noncoding RNAs (lncRNAs) have emerged as a major regulator of cell physiology, but many of which have no known function. CDKN1A/p21 is an important inhibitor of the cell-cycle, regulator of the DNA damage response and effector of the tumor suppr

Externí odkaz: https://doaj.org/article/dbe43e105b9249f599e1f75789e33cc3

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Supplementary Figures 1-3, Table 1 from The lncRNA DRAIC/PCAT29 Locus Constitutes a Tumor-Suppressive Nexus

Autor: Anindya Dutta, Jordan Anaya, Brian J. Reon, Kouhei Sakurai

Supplementary Figures 1-3, Table 1. Supplementary Figure 1: Cellular localization of DRAIC and 3'RACE of DRAIC gene Supplementary Figure 2: Transcriptional variants of DRAIC gene Supplementary Figure 3: AR, FOXA1 and NKX3-1 binding sequences at DRAIC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508422e6c6a8b75119bf8dad53b22561
https://doi.org/10.1158/1541-7786.22514523.v1

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Supplementary Figure 5 from LINC00152 Promotes Invasion through a 3′-Hairpin Structure and Associates with Prognosis in Glioblastoma

Autor: Anindya Dutta, Manjari Kiran, Bruno Takao Real Karia, Brian J. Reon

LINC00152 full length and deletion mutants. A) Predicted secondary structures of LINC00152 deletion mutants. M2 and M3 lack the protein bound stem-loop. M8 is highlighted by the boxed area (nucleotides 280-401). On the other hand, M4 through M8 conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a52028eb97dd56d94c20d44151c5be9
https://doi.org/10.1158/1541-7786.22512964.v1

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Supplementary Figure 2 from LINC00152 Promotes Invasion through a 3′-Hairpin Structure and Associates with Prognosis in Glioblastoma

Autor: Anindya Dutta, Manjari Kiran, Bruno Takao Real Karia, Brian J. Reon

LINC00152 does not affect U87 cell proliferation rate. A) qRT-PCR showing knockdown of LINC00152 after treatment with two different siRNAs. B) Cell proliferation rate measured by MTT assay of U87 cells treated with two different siRNA against LINC001

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097e5a556b163da00a5b8723201e8c56
https://doi.org/10.1158/1541-7786.22512973.v1

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Supplementary Figure 3 from LINC00152 Promotes Invasion through a 3′-Hairpin Structure and Associates with Prognosis in Glioblastoma

Autor: Anindya Dutta, Manjari Kiran, Bruno Takao Real Karia, Brian J. Reon

Expression of genes involved in EMT are decreased by si LINC00152 rescued by LINC00152 m8 overexpression. A-G) qRT-PCR showing (A) LINC00152, (B) TPM2, (C) PTX3, (D) IGFBP4, (E) TGM2, (F) SPP1, (G) LUM expression after siGL2 and pcDNA3, or siLINC0015

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39da164c71dc5e2b09bf67536ec9427a
https://doi.org/10.1158/1541-7786.22512970.v1

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Supplementary Figure 4 from LINC00152 Promotes Invasion through a 3′-Hairpin Structure and Associates with Prognosis in Glioblastoma

Autor: Anindya Dutta, Manjari Kiran, Bruno Takao Real Karia, Brian J. Reon

A protein-bound stem loop in LINC00152. A and B) The two lowest free-energy structures of LINC00152, predicted by mfold. Boxed areas show overlapping stem-loop regions between the structures which also overlaps with the PARIS reads and Ribo-seq reads

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56365bcab34f5232cc14f62f032ad6e0
https://doi.org/10.1158/1541-7786.22512967.v1

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Supplementary Figure 6 from LINC00152 Promotes Invasion through a 3′-Hairpin Structure and Associates with Prognosis in Glioblastoma

Autor: Anindya Dutta, Manjari Kiran, Bruno Takao Real Karia, Brian J. Reon

LINC00152 knockdown leads to changes in gene expression. A) Heatmap showing clustering of replicates from the same condition (with or without LINC00152 knockdown) based on differentially regulated genes in U87 cells. Three biological replicates for e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa894a4f8136a60169816723dfc173f
https://doi.org/10.1158/1541-7786.22512961

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