The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation.

Autor: Raquel M Silva, Iven C N Duarte, João A Paredes, Tatiana Lima-Costa, Michel Perrot, Hélian Boucherie, Brian J Goodfellow, Ana C Gomes, Denisa D Mateus, Gabriela R Moura, Manuel A S Santos

Publikováno v: PLoS ONE, Vol 4, Iss 4, p e5212 (2009)

Translation fidelity is critical for protein synthesis and to ensure correct cell functioning. Mutations in the protein synthesis machinery or environmental factors that increase synthesis of mistranslated proteins result in cell death and degenerati

Externí odkaz: https://doaj.org/article/943e46601d564f488bffc94f1ed080f8

The Long-Term Culture of Human Fibroblasts Reveals a Spectroscopic Signature of Senescence

Autor: Sandra Magalhães, Idália Almeida, Cátia D. Pereira, Sandra Rebelo, Brian J. Goodfellow, Alexandra Nunes

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 10, p 5830 (2022)

Aging is a complex process which leads to progressive loss of fitness/capability/ability, increasing susceptibility to disease and, ultimately, death. Regardless of the organism, there are some features common to aging, namely, the loss of proteostas

Externí odkaz: https://doaj.org/article/8f4e82c7188041aea136acc1bd4c5ef4

The Potential of Metabolomics in the Diagnosis of Thyroid Cancer

Autor: Margarida Coelho, Luis Raposo, Brian J. Goodfellow, Luigi Atzori, John Jones, Bruno Manadas

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 15, p 5272 (2020)

Thyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of

Externí odkaz: https://doaj.org/article/b5b21ce03fa549bc832cc326eb6f0be9

The role of NAD metabolism in neuronal differentiation

Autor: Diogo Neves, Brian J. Goodfellow, Sandra I. Vieira, Raquel M. Silva

Publikováno v: Neurochemistry international. 159

Background: Nicotinamide adenine dinucleotide (NAD) metabolism is involved in redox and non-redox reactions that regulate several processes including differentiation of cells of different origins. Here, the role of NAD metabolism in neuronal differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79d18d4acf3b1ea1fea1b038a7c07e1
https://pubmed.ncbi.nlm.nih.gov/35843422

The SOUL family of heme-binding proteins: Structure and function 15 years later

Autor: Jean-Marc Moulis, Susana S. Aveiro, Anjos L. Macedo, Gloria C. Ferreira, Ana Luísa Carvalho, Alastair G. McEwen, Leonildo Delgado, Brian J. Goodfellow, João E. Rodrigues, Filipe Freire, Peggy Charbonnier, Catherine Birck, Pierre Poussin-Courmontagne

Publikováno v: Coordination Chemistry Reviews
Coordination Chemistry Reviews, Elsevier, 2021, 448, pp.214189. ⟨10.1016/j.ccr.2021.214189⟩
Coordination Chemistry Reviews, 2021, 448, pp.214189. ⟨10.1016/j.ccr.2021.214189⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

International audience; The SOUL, or heme-binding protein HBP/SOUL, family represents a group of evolutionary conservedputative heme-binding proteins that contains a number of members in animal, plant and bacterial spe-cies. The structures of the mur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b16c76ed93d9fb9bcc9fe678e27b4a
https://hal.archives-ouvertes.fr/hal-03364400