Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Brian J Ferguson"'
Autor:
Delphine M Depierreux, Arwen F Altenburg, Lior Soday, Alice Fletcher-Etherington, Robin Antrobus, Brian J Ferguson, Michael P Weekes, Geoffrey L Smith
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010612 (2022)
The interaction between immune cells and virus-infected targets involves multiple plasma membrane (PM) proteins. A systematic study of PM protein modulation by vaccinia virus (VACV), the paradigm of host regulation, has the potential to reveal not on
Externí odkaz:
https://doaj.org/article/259faa9585bf468b837ff3968ef6c20d
Autor:
Evgeniya V Shmeleva, Mercedes Gomez de Agüero, Josef Wagner, Anton J Enright, Andrew J Macpherson, Brian J Ferguson, Geoffrey L Smith
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1009854 (2022)
Interactions between pathogens, host microbiota and the immune system influence many physiological and pathological processes. In the 20th century, widespread dermal vaccination with vaccinia virus (VACV) led to the eradication of smallpox but how VA
Externí odkaz:
https://doaj.org/article/a124d8c9dd2849ddaac0fc6761193878
Autor:
Daniel S Mansur, Carlos Maluquer de Motes, Leonie Unterholzner, Rebecca P Sumner, Brian J Ferguson, Hongwei Ren, Pavla Strnadova, Andrew G Bowie, Geoffrey L Smith
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003183 (2013)
The transcription factor NF-κB is essential for immune responses against pathogens and its activation requires the phosphorylation, ubiquitination and proteasomal degradation of IκBα. Here we describe an inhibitor of NF-κB from vaccinia virus tha
Externí odkaz:
https://doaj.org/article/cc313765ff4e432d98a55176d20ea482
Autor:
Nicholas E Peters, Brian J Ferguson, Michela Mazzon, Aodhnait S Fahy, Ewelina Krysztofinska, Raquel Arribas-Bosacoma, Laurence H Pearl, Hongwei Ren, Geoffrey L Smith
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003649 (2013)
The innate immune system is critical in the response to infection by pathogens and it is activated by pattern recognition receptors (PRRs) binding to pathogen associated molecular patterns (PAMPs). During viral infection, the direct recognition of th
Externí odkaz:
https://doaj.org/article/8467312b42f245ed8576c41b8333664e
Publikováno v:
eLife, Vol 1 (2012)
Innate immunity is the first immunological defence against pathogens. During virus infection detection of nucleic acids is crucial for the inflammatory response. Here we identify DNA-dependent protein kinase (DNA-PK) as a DNA sensor that activates in
Externí odkaz:
https://doaj.org/article/d3ee242b4e3c42d78a90cb34a622dffc
Autor:
Gareth W Morgan, Michael Hollinshead, Brian J Ferguson, Brendan J Murphy, David C J Carpentier, Geoffrey L Smith
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000785 (2010)
Vaccinia virus (VACV) uses microtubules for export of virions to the cell surface and this process requires the viral protein F12. Here we show that F12 has structural similarity to kinesin light chain (KLC), a subunit of the kinesin-1 motor that bin
Externí odkaz:
https://doaj.org/article/0f8252ab83c347159bcb82075b3cb84e
Autor:
Dayana B. Hristova, Marisa Oliveira, Emma Wagner, Alan Melcher, Kevin J. Harrington, Alexandre Belot, Brian J. Ferguson
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108760- (2024)
Summary: To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription. The mechanisms by which intracellular DNA and DNA viruses
Externí odkaz:
https://doaj.org/article/8680f83534b149dda80b6f319b71b2a1
Autor:
Taissa Ricciardi-Jorge, Edroaldo Lummertz da Rocha, Edgar Gonzalez-Kozlova, Gabriela Flavia Rodrigues-Luiz, Brian J. Ferguson, Trevor Sweeney, Nerea Irigoyen, Daniel Santos Mansur
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The mechanisms by which flaviviruses use non-canonical translation to support their replication in host cells are largely unknown. Here, we investigated how the integrated stress response (ISR), which promotes translational arrest by eIF2ɑ
Externí odkaz:
https://doaj.org/article/3a9c992b85ff4378bdf9eb88eb9b977c
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Natural killer (NK) cells have an established role in controlling poxvirus infection and there is a growing interest to exploit their capabilities in the context of poxvirus-based oncolytic therapy and vaccination. How NK cells respond to poxvirus-in
Externí odkaz:
https://doaj.org/article/069429abc2624410aca2c4d5a830bb34
Autor:
Rahul Singh, Yuan Wu, Alba Herrero del Valle, Kendra E Leigh, Mark T. K. Cheng, Brian J Ferguson, Yorgo Modis
Cytosolic long double-stranded RNA (dsRNA), among the most potent proinflammatory signals, is recognized by MDA5. MDA5 binds dsRNA cooperatively, forming helical filaments. ATP hydrolysis by MDA5 fulfills a proofreading function by promoting dissocia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe2f6b24e8ddea749dc3c1f23e57458b
https://doi.org/10.1101/2023.05.25.542247
https://doi.org/10.1101/2023.05.25.542247
