Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Brian J A Gill"'
Autor:
Osama Al-Dalahmah, Michael G. Argenziano, Adithya Kannan, Aayushi Mahajan, Julia Furnari, Fahad Paryani, Deborah Boyett, Akshay Save, Nelson Humala, Fatima Khan, Juncheng Li, Hong Lu, Yu Sun, John F. Tuddenham, Alexander R. Goldberg, Athanassios Dovas, Matei A. Banu, Tejaswi Sudhakar, Erin Bush, Andrew B. Lassman, Guy M. McKhann, Brian J. A. Gill, Brett Youngerman, Michael B. Sisti, Jeffrey N. Bruce, Peter A. Sims, Vilas Menon, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic r
Externí odkaz:
https://doaj.org/article/84706af8be0f4cffa61c89d018e75e54
Autor:
Brian J A Gill, Farhan A Khan, Alexander R Goldberg, Edward M Merricks, Xiaoping Wu, Alexander A Sosunov, Tejaswi D Sudhakar, Athanassios Dovas, Wudu Lado, Andrew J Michalak, Jia Jie Teoh, Jyun-you Liou, Wayne N Frankel, Guy M McKhann, Peter Canoll, Catherine A Schevon
Publikováno v:
Brain
While several studies have attributed the development of tumour-associated seizures to an excitatory-inhibitory imbalance, we have yet to resolve the spatiotemporal interplay between different types of neuron in glioma-infiltrated cortex. Herein, we
Autor:
Eleonora F Spinazzi, Michael G Argenziano, Pavan S Upadhyayula, Matei A Banu, Justin A Neira, Dominique M O Higgins, Peter B Wu, Brianna Pereira, Aayushi Mahajan, Nelson Humala, Osama Al-Dalahmah, Wenting Zhao, Akshay V Save, Brian J A Gill, Deborah M Boyett, Tamara Marie, Julia L Furnari, Tejaswi D Sudhakar, Sylwia A Stopka, Michael S Regan, Vanessa Catania, Laura Good, Stergios Zacharoulis, Meenu Behl, Petros Petridis, Sachin Jambawalikar, Akiva Mintz, Angela Lignelli, Nathalie Y R Agar, Peter A Sims, Mary R Welch, Andrew B Lassman, Fabio M Iwamoto, Randy S D’Amico, Jack Grinband, Peter Canoll, Jeffrey N Bruce
Publikováno v:
Lancet Oncol
Topotecan is cytotoxic to glioma cells but is clinically ineffective because of drug delivery limitations. Systemic delivery is limited by toxicity and insufficient brain penetrance, and, to date, convection-enhanced delivery (CED) has been restricte
Autor:
Christopher Troy, Brian J A Gill, Michael L Miller, Richard A Hickman, Peter Canoll, Stergios Zacharoulis, Neil A Feldstein, Jeffrey N Bruce
Publikováno v:
Journal of neuropathology and experimental neurology. 81(4)
Autor:
Osama Al-Dalahmah, Michael G. Argenziano, Adithya Kannan, Aayushi Mahajan, Julia Furnari, Fahad Paryani, Deborah Boyett, Akshay Save, Nelson Humala, Fatima Khan, Juncheng Li, Hong Lu, Yu Sun, John F. Tuddenham, Alexander R. Goldberg, Athanassios Dovas, Matei A. Banu, Tejaswi Sudhakar, Erin Bush, Andrew B. Lassman, Guy M. McKhann, Brian J. A. Gill, Brett Youngerman, Michael B. Sisti, Jeffrey N. Bruce, Peter A. Sims, Vilas Menon, Peter Canoll
Glioblastoma (GBM) is an aggressive diffusely infiltrating neoplasm that spreads beyond surgical resection margins, where it intermingles with non-neoplastic brain cells. This complex microenvironment harboring infiltrating glioma and non-neoplastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44177c8c58ef99e2617f35d5a72693a4
https://doi.org/10.1101/2021.07.06.451295
https://doi.org/10.1101/2021.07.06.451295
Publikováno v:
Neurosurgery. 90:e86-e87
Autor:
Edward M. Merricks, Guy M. McKhann, Catherine A. Schevon, Steven Tobochnik, Lisa M. Bateman, Tahra L. Eissa, Brian J A Gill, Andrew J. Trevelyan, R. Ryley Parrish, Ronald G. Emerson
Publikováno v:
Neurobiology of Disease, Vol 127, Iss, Pp 303-311 (2019)
Neurobiol Dis
Neurobiol Dis
The cellular activity underlying human focal seizures, and its relationship to key signatures in the EEG recordings used for therapeutic purposes, has not been well characterized despite many years of investigation both in laboratory and clinical set
Autor:
Xiaoping, Wu, Alexander A, Sosunov, Wudu, Lado, Jia Jie, Teoh, Ahrom, Ham, Hongyu, Li, Osama, Al-Dalahmah, Brian J A, Gill, Ottavio, Arancio, Catherine A, Schevon, Wayne N, Frankel, Guy M, McKhann, David, Sulzer, James E, Goldman, Guomei, Tang
Publikováno v:
Cell Reports. 40:111085
Tuberous sclerosis complex (TSC) is a developmental disorder associated with epilepsy, autism, and cognitive impairment. Despite inactivating mutations in the TSC1 or TSC2 genes and hyperactive mechanistic target of rapamycin (mTOR) signaling, the me
Autor:
Xiaoping Wu, Alexander R. Goldberg, Tejaswi Sudhakar, Jyun-you Liou, Athanassios Dovas, Edward M. Merricks, Guy M. McKhann, Alexander A. Sosunov, Farhan A. Khan, Brian J A Gill, Catherine A. Schevon, Peter Canoll
Several studies have attributed the development of tumor-associated seizures to an excitatory-inhibitory imbalance, highlighting the importance of resolving the spatiotemporal interplay of different neuronal populations within the peritumoral microen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88c8e425fc729802e8e4bc10d49b151a
https://doi.org/10.1101/2021.02.23.432381
https://doi.org/10.1101/2021.02.23.432381
Publikováno v:
Journal of neurosurgical sciences. 63(6)
Standard of care in the management of high-grade gliomas includes gross total resection (GTR) followed by treatment with radiation and temozolomide. GTR remains one of the few independent prognostic factors for improved survival in this disease. Sodi