Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Brian J, Stevenson"'
Immunopeptidomics-based identification of naturally presented non-canonical circRNA-derived peptides
Autor:
Humberto J. Ferreira, Brian J. Stevenson, HuiSong Pak, Fengchao Yu, Jessica Almeida Oliveira, Florian Huber, Marie Taillandier-Coindard, Justine Michaux, Emma Ricart-Altimiras, Anne I. Kraemer, Lana E. Kandalaft, Daniel E. Speiser, Alexey I. Nesvizhskii, Markus Müller, Michal Bassani-Sternberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Circular RNAs (circRNAs) are covalently closed non-coding RNAs lacking the 5’ cap and the poly-A tail. Nevertheless, it has been demonstrated that certain circRNAs can undergo active translation. Therefore, aberrantly expressed circRNAs in
Externí odkaz:
https://doaj.org/article/aa13b660fd674c718d5106fcd51ebb43
Autor:
Julien Schmidt, Johanna Chiffelle, Marta A. S. Perez, Morgane Magnin, Sara Bobisse, Marion Arnaud, Raphael Genolet, Julien Cesbron, David Barras, Blanca Navarro Rodrigo, Fabrizio Benedetti, Alexandra Michel, Lise Queiroz, Petra Baumgaertner, Philippe Guillaume, Michael Hebeisen, Olivier Michielin, Tu Nguyen-Ngoc, Florian Huber, Melita Irving, Stéphanie Tissot-Renaud, Brian J. Stevenson, Sylvie Rusakiewicz, Denarda Dangaj Laniti, Michal Bassani-Sternberg, Nathalie Rufer, David Gfeller, Lana E. Kandalaft, Daniel E. Speiser, Vincent Zoete, George Coukos, Alexandre Harari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The success of cancer immunotherapy depends in part on the strength of antigen recognition by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen sensitivity) and structural (monomeric pMHC-TCR off-rates) avidities o
Externí odkaz:
https://doaj.org/article/07eeb33e654749ddb84ed54edf7d260f
Autor:
Hajer Fritah, Michele Graciotti, Cheryl Lai-Lai Chiang, Anne-Laure Huguenin- Bergenat, Rémy Petremand, Ritaparna Ahmed, Philippe Guillaume, Julien Schmidt, Brian J. Stevenson, David Gfeller, Alexandre Harari, Lana E. Kandalaft
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106288- (2023)
Summary: Antigen selection and prioritization represent crucial determinants of vaccines’ efficacy. Here, we compare two personalized dendritic cell-based vaccination strategies using whole-tumor lysate or neoantigens. Data in mouse and in cancer p
Externí odkaz:
https://doaj.org/article/9001342654b947c8becf2723dc803e5f
Autor:
Janos L. Tanyi, Cheryl L.-L. Chiang, Johanna Chiffelle, Anne-Christine Thierry, Petra Baumgartener, Florian Huber, Christine Goepfert, David Tarussio, Stephanie Tissot, Drew A. Torigian, Harvey L. Nisenbaum, Brian J. Stevenson, Hajer Fritah Guiren, Ritaparna Ahmed, Anne-Laure Huguenin-Bergenat, Emese Zsiros, Michal Bassani-Sternberg, Rosemarie Mick, Daniel J. Powell, George Coukos, Alexandre Harari, Lana E. Kandalaft
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract T cells are important for controlling ovarian cancer (OC). We previously demonstrated that combinatorial use of a personalized whole-tumor lysate-pulsed dendritic cell vaccine (OCDC), bevacizumab (Bev), and cyclophosphamide (Cy) elicited neo
Externí odkaz:
https://doaj.org/article/ba1d3a5199c64080b68ad63708532dda
Autor:
Chloe Chong, Markus Müller, HuiSong Pak, Dermot Harnett, Florian Huber, Delphine Grun, Marion Leleu, Aymeric Auger, Marion Arnaud, Brian J. Stevenson, Justine Michaux, Ilija Bilic, Antje Hirsekorn, Lorenzo Calviello, Laia Simó-Riudalbas, Evarist Planet, Jan Lubiński, Marta Bryśkiewicz, Maciej Wiznerowicz, Ioannis Xenarios, Lin Zhang, Didier Trono, Alexandre Harari, Uwe Ohler, George Coukos, Michal Bassani-Sternberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Non-canonical HLA-bound peptides from presumed non-coding regions are potential targets for cancer immunotherapy, but their discovery remains challenging. Here, the authors integrate exome sequencing, transcriptomics, ribosome profiling, and immunope
Externí odkaz:
https://doaj.org/article/f9a358af84884389af3e4820907dade6
Autor:
Martin F Bachmann, Said Dermime, Daniel E Speiser, Monique Vogel, Georges Coukos, Varghese Philipose Inchakalody, Mona O Mohsen, Justine Michaux, HuiSong Pak, Brian J Stevenson, Simone de Brot, Michal Bassani-Sternberg
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/214a03bc5acf409c9a81b744a3de7f23
Autor:
Alice Newey, Beatrice Griffiths, Justine Michaux, Hui Song Pak, Brian J. Stevenson, Andrew Woolston, Maria Semiannikova, Georgia Spain, Louise J. Barber, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, George Coukos, Julien Racle, David Gfeller, Naureen Starling, David Cunningham, Michal Bassani-Sternberg, Marco Gerlinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Background Patient derived organoids (PDOs) can be established from colorectal cancers (CRCs) as in vitro models to interrogate cancer biology and its clinical relevance. We applied mass spectrometry (MS) immunopeptidomics to investigate neo
Externí odkaz:
https://doaj.org/article/32b7ab7a83d34330933a0f79b7abfe76
Autor:
Apostolos Sarivalasis, Caroline Boudousquié, Klara Balint, Brian J. Stevenson, Philippe O. Gannon, Emanuela Marina Iancu, Laetitia Rossier, Silvia Martin Lluesma, Patrice Mathevet, Christine Sempoux, George Coukos, Urania Dafni, Alexandre Harari, Michal Bassani-Sternberg, Lana E. Kandalaft
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background Most ovarian cancer patients are diagnosed at a late stage with 85% of them relapsing after surgery and standard chemotherapy; for this reason, new treatments are urgently needed. Ovarian cancer has become a candidate for immunoth
Externí odkaz:
https://doaj.org/article/32c4093eeb7a4550bc29df185dcfea86
Autor:
Anne I. Kraemer, Chloe Chong, Florian Huber, HuiSong Pak, Brian J. Stevenson, Markus Müller, Justine Michaux, Emma Ricart Altimiras, Sylvie Rusakiewicz, Laia Simó-Riudalbas, Evarist Planet, Maciej Wiznerowicz, Julien Dagher, Didier Trono, George Coukos, Stephanie Tissot, Michal Bassani-Sternberg
Publikováno v:
Nature cancer, vol. 4, no. 5, pp. 608-628
One key barrier to improving efficacy of personalized cancer immunotherapies that are dependent on the tumor antigenic landscape remains patient stratification. Although patients with CD3+CD8+ T cell-inflamed tumors typically show better response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c7f7bff6f08a7d5efa2ad8565da395
https://doi.org/10.1038/s43018-023-00548-5
https://doi.org/10.1038/s43018-023-00548-5
Autor:
Sara Bobisse, Raphael Genolet, Annalisa Roberti, Janos L. Tanyi, Julien Racle, Brian J. Stevenson, Christian Iseli, Alexandra Michel, Marie-Aude Le Bitoux, Philippe Guillaume, Julien Schmidt, Valentina Bianchi, Denarda Dangaj, Craig Fenwick, Laurent Derré, Ioannis Xenarios, Olivier Michielin, Pedro Romero, Dimitri S. Monos, Vincent Zoete, David Gfeller, Lana E. Kandalaft, George Coukos, Alexandre Harari
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Epithelial ovarian cancer (EOC) has low mutational load. Here the authors analyze circulating and tumor-infiltrating lymphocytes (TILs) from 19 EOC patients and report frequent recovery of neo-antigen-reactive T cells from both compartments but with
Externí odkaz:
https://doaj.org/article/f208f1e6db6944a78773c68825834778