Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Brian J, Knoll"'
Autor:
Nour Al-Sawalha, Indira Pokkunuri, Ozozoma Omoluabi, Hosu Kim, Vaidehi J Thanawala, Adrian Hernandez, Richard A Bond, Brian J Knoll
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132559 (2015)
Mucus hypersecretion by airway epithelium is a hallmark of inflammation in allergic asthma and results in airway narrowing and obstruction. Others have shown that administration a TH2 cytokine, IL-13 is sufficient to cause mucus hypersecretion in viv
Externí odkaz:
https://doaj.org/article/878dd13d12874a7e866e2d60b1e4fa78
Autor:
Richard A. Bond, Hosu Kim, Brian J. Knoll, Douglas C. Eikenburg, Radhika Joshi, Daniel Valdez
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 46:30-40
Our previous studies suggested certain β-adrenoceptor blockers (β-blockers) attenuate the asthma phenotype in ovalbumin driven murine models of asthma. However, the ovalbumin model has been criticized for lack of clinical relevance.We tested the no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaa0fc950ad44aad1c3d04e2b097fdc
https://doi.org/10.1016/j.pupt.2017.07.004
https://doi.org/10.1016/j.pupt.2017.07.004
Autor:
Nour A. Al-Sawalha, Brian J. Knoll
Publikováno v:
Pharmacology. 98:279-283
The effect of stains in asthma is mediated through targeting several signaling molecules that are involved in the development of asthma phenotype. In vitro and in vivo studies revealed that statins reduce airway smooth muscle cells proliferation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca457f729bb69942db370cfa7d0eb5cf
https://doi.org/10.1159/000449062
https://doi.org/10.1159/000449062
Autor:
G S Forkuo, Paul Leff, Daniel Valdez, Brian J. Knoll, Richard A. Bond, Vaidehi J. Thanawala, Sergio Parra, Radhika Joshi, Michel Bouvier
Publikováno v:
British Journal of Pharmacology. 172:4833-4846
Background and purpose Our previous studies have shown the β2 -adrenoceptor and its endogenous ligand, adrenaline, are required for development of the asthma phenotype in murine asthma models. Chronic administration of some, but not other, β-blocke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9070faf31ed1e675b388182841e47d44
https://doi.org/10.1111/bph.13253
https://doi.org/10.1111/bph.13253
Autor:
Long P, Nguyen, Nour A, Al-Sawalha, Sergio, Parra, Indira, Pokkunuri, Ozozoma, Omoluabi, Adedoyin A, Okulate, Elizabeth, Windham Li, Matthew, Hazen, Jose M, Gonzalez-Granado, Craig J, Daly, John C, McGrath, Michael J, Tuvim, Brian J, Knoll, Burton F, Dickey, Richard A, Bond
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(43)
Activation of β2-adrenoreceptors (β2ARs) on airway smooth muscle cells produces airway relaxation, and β2AR agonists are the most widely used bronchodilators for treating asthma. Paradoxically, murine models show β2AR activation is also required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1aab383016efb0285a6a2c878b54729f
https://pubmed.ncbi.nlm.nih.gov/29073113
https://pubmed.ncbi.nlm.nih.gov/29073113
Autor:
Jose M. Gonzalez-Granado, Ozozoma Omoluabi, Michael J. Tuvim, John C. McGrath, Craig J. Daly, Indira Pokkunuri, Adedoyin A. Okulate, Richard A. Bond, Burton F. Dickey, Sergio Parra, Brian J. Knoll, Elizabeth Windham Li, Long P. Nguyen, Matthew L. Hazen, Nour A. Al-Sawalha
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
The mostly widely used bronchodilators in asthma therapy are β2-adrenoreceptor (β2AR) agonists, but their chronic use causes paradoxical adverse effects. We have previously determined that β2AR activation is required for expression of the asthma p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9fd2571be12d4f93efed13cd1e50cc
https://doi.org/10.1073/pnas.1710196114
https://doi.org/10.1073/pnas.1710196114
Autor:
Tonio Pera, Patricia Gonnella, Radhika Joshi, Gloria S. Forkuo, Brian J. Knoll, Sergio Parra, Hosu Kim, Vaidehi J. Thanawala, Raymond B. Penn, Daniel Valdez, Nour A. Al-Sawalha, Richard A. Bond, Julia K. L. Walker
Mice lacking the endogenous β2-adrenoceptor (β2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e9a4932f7d2cff6c9abd872692aac2
https://europepmc.org/articles/PMC4979368/
https://europepmc.org/articles/PMC4979368/
Autor:
Parminder Kaur, Yoshitaka Yano, Riya Shah, Tasana Pitaksuteepong, Brian J. Knoll, Karl B. Lemström, Argyro Fassoulaki, Young Min Bae, Christian Humpel, Noppawan Phumala Morales, Yan-yan Song, Bing Chen, Hyoweon Bang, Arada Khunakornvichaya, Tímea Bencsik, E. Holmström, Phi Phuong Pham, Sujinna Lekmeechai, Amy L. Firth, Won Sun Park, Nour A. Al-Sawalha, Ziya Kaygisiz, Erica D. Thomasson, Yasemin Aydin, Adel H. Omar, Marina Markidou, Mohamed Elsayed Kelany, Bei-Ming Xu, Periklis Pappas, Tanveer Singh Kundra, Abha Sahni, Raimo Tuuminen, Sanjeev K. Sahni, Zsolt Sándor, Hao Chen, Bianca Hutter-Schmid, Hye Won Kim, Han Sol Kim, Vangelis Karalis, Yugo Chisaki, Tomohiro Terada, Xiao-Xue Liu, Il-Whan Choi, Loránd Barthó, Wanwisa Himakoun, Seok-Ho Hong, Andras Dekany, Sung Eun Shin, Theodoros Vougiouklakis, Neda Yousefirad, Hongliang Li, Eun-Taek Han, Mohamed A. Abdallah, Petros N. Karamanakos, Vasiliki Boumba, Sophia L. Markantonis, Tahir Hakami, Warinkarn Hemstapat, Aikaterini Melemeni, Marios Marselos, Won-Kyo Jung, Kwon-Soo Ha, Stefania Irene Haikali, Druckerei Stückle, Wan-hua Yang
Publikováno v:
Pharmacology. 98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31819d66974a3b815ec439544e6b656e
https://doi.org/10.1159/000453101
https://doi.org/10.1159/000453101
Autor:
Haibin Zhang, Robert H. Moore, Andrew J. Bean, Haixia Zhang, Veronica Godines, Ellen E. Millman, Brian J. Knoll
Publikováno v:
Traffic. 9:1958-1971
For the beta(2)-adrenergic receptor (beta(2)AR), published evidence suggests that an intact actin cytoskeleton is required for the endocytosis of receptors and their proper sorting to the rapid recycling pathway. We have characterized the role of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34738f126681d93a7b0cc477062cdec
https://doi.org/10.1111/j.1600-0854.2008.00813.x
https://doi.org/10.1111/j.1600-0854.2008.00813.x
Autor:
Felix R. Shardonofsky, Rui Lin, Noor B. Dudekula, Richard A. Bond, Sergio Parra, Hui Peng, Brian J. Knoll, Long P. Nguyen
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 21:115-124
We have previously reported that chronic treatment with certain 'beta-blockers' reduces airway hyperresponsiveness (AHR) to methacholine in a murine model of asthma.Airway resistance was measured using the forced oscillation technique in ovalbulmin-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134e5c5b56c50c2bfb489d61cd5bded8
https://doi.org/10.1016/j.pupt.2007.06.003
https://doi.org/10.1016/j.pupt.2007.06.003