Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Brian J, Hawkins"'
Autor:
Surya Kotha, Brian J. Hawkins, Raluca Marcu, Zhongwei Zhi, Ruikang K. Wang, Ying Zheng, Wan Qin, Christopher K. Neeley
Publikováno v:
Circulation Research. 116:1336-1345
Rationale: The mitochondrial permeability transition pore is a well-known initiator of cell death that is increasingly recognized as a physiological modulator of cellular metabolism. Objective: We sought to identify how the genetic deletion of a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5487003bfb3ef43c74470d0a7e11d9a8
https://doi.org/10.1161/circresaha.116.304881
https://doi.org/10.1161/circresaha.116.304881
Publikováno v:
Advances in experimental medicine and biology. 982
Angiogenesis is a dynamic and energy-consuming process, requiring endothelial cells to switch from a quiescent state to a migratory and proliferative phenotype in order to support the formation of new blood vessels. Despite their proximity to oxygena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::299a57bc0391ca68a47cc6f67804096d
https://pubmed.ncbi.nlm.nih.gov/28551799
https://pubmed.ncbi.nlm.nih.gov/28551799
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319553290
Angiogenesis is a dynamic and energy-consuming process, requiring endothelial cells to switch from a quiescent state to a migratory and proliferative phenotype in order to support the formation of new blood vessels. Despite their proximity to oxygena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e057b4716fad2ce09f8806871b89a1
https://doi.org/10.1007/978-3-319-55330-6_21
https://doi.org/10.1007/978-3-319-55330-6_21
Publikováno v:
Molecular and Cellular Biology. 34:2890-2902
Mitochondrial calcium uptake stimulates bioenergetics and drives energy production in metabolic tissue. It is unknown how a calcium-mediated acceleration in matrix bioenergetics would influence cellular metabolism in glycolytic cells that do not requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f4f8beb01b98f42a9928021d4d87d7
https://doi.org/10.1128/mcb.00068-14
https://doi.org/10.1128/mcb.00068-14
Publikováno v:
Biochemical and Biophysical Research Communications. 444:44-49
The isothiourea derivative, KB-R7943, inhibits the reverse-mode of the plasma membrane sodium/calcium exchanger and protects against ischemia/reperfusion injury. The mechanism through which KB-R7943 confers protection, however, remains controversial.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcfa5ce545157a8764f6c1833c3e8c7
https://doi.org/10.1016/j.bbrc.2014.01.009
https://doi.org/10.1016/j.bbrc.2014.01.009
Autor:
Jingyan Han, Marian T. Nakada, Vladimir R. Muzykantov, Muniswamy Madesh, Brian J. Hawkins, Shaohui Huang, Kevin Yu, Vladimir V. Shuvaev
Publikováno v:
The FASEB Journal. 25:348-357
Elevated generation of reactive oxygen species (ROS) by endothelial enzymes, including NADPH-oxidase, is implicated in vascular oxidative stress and endothelial proinflammatory activation involving exposure of vascular cell adhesion molecule-1 (VCAM-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c97e4fcd0e088208cd3027c93f365c
https://doi.org/10.1096/fj.10-169789
https://doi.org/10.1096/fj.10-169789
Autor:
Donald L. Gill, Michael F. Ritchie, Cunnigaiper D. Bhanumathy, Yu Chin Lien, Suresh K. Joseph, Tomohiro Kurosaki, Yoshihiro Baba, Brian J. Hawkins, Jonathan Soboloff, Muniswamy Madesh, Ramasamy Subbiah, Youjun Wang, Krishna M. Irrinki, Karthik Mallilankaraman
Publikováno v:
The Journal of Cell Biology
Oxidant stress induces constitutive calcium entry by tacking glutathiones onto the Orai CRAC channel activator STIM1.
Oxidant stress influences many cellular processes, including cell growth, differentiation, and cell death. A well-recognized li
Oxidant stress influences many cellular processes, including cell growth, differentiation, and cell death. A well-recognized li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f55bdcbb509ae47e23cf3aa9e66a129
https://doi.org/10.1083/jcb.201004152
https://doi.org/10.1083/jcb.201004152
Autor:
Varsha P. Daswani, Patrick J. Doonan, Yefim Manevich, Brian J. Hawkins, Krishna M. Irrinki, Bruce A. Cameron, Muniswamy Madesh, Subbiah Ramasamy, Christiana Davis, Khalid Islam
Publikováno v:
Free Radical Biology and Medicine. 48:306-317
Nitric oxide (NO) and other reactive nitrogen species target multiple sites in the mitochondria to influence cellular bioenergetics and survival. Kinetic imaging studies revealed that NO from either activated macrophages or donor compounds rapidly di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4696de5e4fcd2f42ad24358434ceaf07
https://doi.org/10.1016/j.freeradbiomed.2009.11.001
https://doi.org/10.1016/j.freeradbiomed.2009.11.001
Autor:
Pal Pacher, Patrick J. Doonan, Mohanraj Rajesh, Craig B. Thompson, Muniswamy Madesh, Subbiah Ramasamy, Thilagavathi Venkatachalam, Brian J. Hawkins, Krishna M. Irrinki, Partha Mukhopadhyay, Wei-Xing Zong
Publikováno v:
Molecular and Cellular Biology. 29:3099-3112
Alcoholic liver disease leads to hepatocyte death, liver cirrhosis, and organ dysfunction and is a major cause of death in the United States (22, 23, 37). Hepatocyte injury is most prominent in the centrilobular region of the liver acinus and stems f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9da0427f3afcb183f2719c1693310b
https://doi.org/10.1128/mcb.01845-08
https://doi.org/10.1128/mcb.01845-08
Autor:
Shampa Chatterjee, Kris DeBolt, Jonni S. Moore, Tatyana N. Milovanova, Elena M. Sorokina, Muniswamy Madesh, Brian J. Hawkins, Aron B. Fisher, Nankang Hong
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783:1866-1875
Abrupt cessation of flow representing the acute loss of shear stress (simulated ischemia) to flow-adapted pulmonary microvascular endothelial cells (PMVEC) leads to reactive oxygen species (ROS) generation that signals for EC proliferation. We evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84adc54d5313a3f1ac38c5cbebbead61
https://doi.org/10.1016/j.bbamcr.2008.05.010
https://doi.org/10.1016/j.bbamcr.2008.05.010