Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Brian J, Cummings"'
Autor:
Noriko Kamei, Kenneth Day, Wei Guo, Daniel L. Haus, Hal X. Nguyen, Vanessa M. Scarfone, Keith Booher, Xi-Yu Jia, Brian J. Cummings, Aileen J. Anderson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Spinal cord injury creates an inflammatory microenvironment that regulates the capacity of transplanted human Neural Stem Cells (hNSC) to migrate, differentiate, and repair injury. Despite similarities in gene expression and markers detected
Externí odkaz:
https://doaj.org/article/91cfd6e877464624b034fe2137543180
Autor:
Usha Nekanti, Pooja S. Sakthivel, Atena Zahedi, Dana A. Creasman, Rebecca A. Nishi, Courtney M. Dumont, Katja M. Piltti, Glenn L. Guardamondo, Norbert Hernandez, Xingyuan Chen, Hui Song, Xiaoxiao Lin, Joshua Martinez, Lillian On, Anita Lakatos, Kiran Pawar, Brian T. David, Zhiling Guo, Stephanie K. Seidlits, Xiangmin Xu, Lonnie D. Shea, Brian J. Cummings, Aileen J. Anderson
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-20 (2024)
Abstract Regeneration in the injured spinal cord is limited by physical and chemical barriers. Acute implantation of a multichannel poly(lactide-co-glycolide) (PLG) bridge mechanically stabilizes the injury, modulates inflammation, and provides a per
Externí odkaz:
https://doaj.org/article/a83ff1b397fa4089b91e5e42b4e4bde0
Autor:
Anna Badner, Brian J Cummings
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 11, Pp 2351-2354 (2022)
Although there is ample evidence that central nervous system progenitor pools respond to traumatic brain injury, the reported effects are variable and likely contribute to both recovery as well as pathophysiology. Through a better understanding of th
Externí odkaz:
https://doaj.org/article/7d07e3b334204fd4953e17f5abe54f3b
Autor:
Katja M. Piltti, Gabriella M. Funes, Sabrina N. Avakian, Ara A. Salibian, Kevin I. Huang, Krystal Carta, Noriko Kamei, Lisa A. Flanagan, Edwin S. Monuki, Nobuko Uchida, Brian J. Cummings, Aileen J. Anderson
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1534-1548 (2017)
Multipotent human central nervous system-derived neural stem cells transplanted at doses ranging from 10,000 (low) to 500,000 (very high) cells differentiated predominantly into the oligodendroglial lineage. However, while the number of engrafted cel
Externí odkaz:
https://doaj.org/article/9fa2f646accf495fbb127312df542fdb
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 249-263 (2017)
We previously showed the efficacy of multiple research cell lines (RCLs) of human CNS neural stem cells (HuCNS-SCs) in mouse and rat models of thoracic spinal cord injury (SCI), supporting a thoracic SCI clinical trial. Experts recommend in vivo prec
Externí odkaz:
https://doaj.org/article/b9fc8354d588410589fd73e38afb15c2
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 195-197 (2017)
Externí odkaz:
https://doaj.org/article/f14e95196566446c996e47ead9eecda1
Autor:
Eric M. Gold, Vitaly Vasilevko, Jonathan Hasselmann, Casey Tiefenthaler, Danny Hoa, Kasuni Ranawaka, David H. Cribbs, Brian J. Cummings
Publikováno v:
ASN Neuro, Vol 10 (2018)
An estimated 5.3 million Americans are living with a disability from a traumatic brain injury (TBI). There is emerging evidence of the detrimental effects from repeated mild TBIs (rmTBIs). rmTBI manifests its own unique set of behavioral and neuropat
Externí odkaz:
https://doaj.org/article/c5f9cb7c907d4270bdd53db1d6823c7b
Autor:
Katja M. Piltti, Sabrina N. Avakian, Gabriella M. Funes, Antoinette Hu, Nobuko Uchida, Aileen J. Anderson, Brian J. Cummings
Publikováno v:
Stem Cell Research, Vol 15, Iss 2, Pp 341-353 (2015)
The effect of transplantation dose on the spatiotemporal dynamics of human neural stem cell (hNSC) engraftment has not been quantitatively evaluated in the central nervous system. We investigated changes over time in engraftment/survival, proliferati
Externí odkaz:
https://doaj.org/article/1136d545b49c40e9a699d4692a6dc2e2
Autor:
Stefania Beretta, Kelly M. Cunningham, Daniel L. Haus, Eric M. Gold, Harvey Perez, Luci López-Velázquez, Brian J. Cummings
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Traumatic brain injury (TBI) is one of the leading causes of death and disability in the population worldwide, with a broad spectrum of symptoms and disabilities. Posttraumatic hyperexcitability is one of the most common neurological disorders that a
Externí odkaz:
https://doaj.org/article/dda844fe5b544e0d94fae15628416cda
Autor:
Daniel L. Haus, Hal X. Nguyen, Eric M. Gold, Noriko Kamei, Harvey Perez, Harry D. Moore, Aileen J. Anderson, Brian J. Cummings
Publikováno v:
Stem Cell Research, Vol 13, Iss 2, Pp 214-226 (2014)
Common methods for the generation of human embryonic-derived neural stem cells (hNSCs) result in cells with potentially compromised safety profiles due to maintenance of cells in conditions containing non-human proteins (e.g. in bovine serum or on mo
Externí odkaz:
https://doaj.org/article/0afe92b0566e46269311a9bc172a542f