Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Brian Houck-Loomis"'
Autor:
Antonio Strillacci, Pasquale Sansone, Vinagolu K. Rajasekhar, Mesruh Turkekul, Vitaly Boyko, Fanli Meng, Brian Houck-Loomis, David Brown, Michael F. Berger, Ronald C. Hendrickson, Qing Chang, Elisa de Stanchina, Fresia Pareja, Jorge S. Reis-Filho, Ramya Segu Rajappachetty, Isabella Del Priore, Bo Liu, Yanyan Cai, Alex Penson, Chiara Mastroleo, Marjan Berishaj, Francesca Borsetti, Enzo Spisni, David Lyden, Sarat Chandarlapaty, Jacqueline Bromberg
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone binding pocket is
Externí odkaz:
https://doaj.org/article/f78ea24d939745a8868b8fcd4d4bff37
Autor:
Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yingqian A. Zhan, Maysun M. Hasan, Shweta S. Chavan, Fanli Meng, Fathema Uddin, Viola Allaj, Parvathy Manoj, Nisargbhai S. Shah, Joseph M. Chan, Metamia Ciampricotti, Andrew Chow, Michael Offin, Jordana Ray-Kirton, Jacklynn D. Egger, Umesh K. Bhanot, Irina Linkov, Marina Asher, Michael H. Roehrl, Katia Ventura, Juan Qiu, Elisa de Stanchina, Jason C. Chang, Natasha Rekhtman, Brian Houck-Loomis, Richard P. Koche, Helena A. Yu, Triparna Sen, Charles M. Rudin
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Background Lineage plasticity, the ability to transdifferentiate among distinct phenotypic identities, facilitates therapeutic resistance in cancer. In lung adenocarcinomas (LUADs), this phenomenon includes small cell and squamous cell (LUSC
Externí odkaz:
https://doaj.org/article/4c6ed1ab46b04936a848bae9af7bc67d
Autor:
Dana W. Y. Tsui, Michael L. Cheng, Maha Shady, Julie L. Yang, Dennis Stephens, Helen Won, Preethi Srinivasan, Kety Huberman, Fanli Meng, Xiaohong Jing, Juber Patel, Maysun Hasan, Ian Johnson, Erika Gedvilaite, Brian Houck-Loomis, Nicholas D. Socci, S. Duygu Selcuklu, Venkatraman E. Seshan, Hongxin Zhang, Debyani Chakravarty, Ahmet Zehir, Ryma Benayed, Maria Arcila, Marc Ladanyi, Samuel A. Funt, Darren R. Feldman, Bob T. Li, Pedram Razavi, Jonathan Rosenberg, Dean Bajorin, Gopa Iyer, Wassim Abida, Howard I. Scher, Dana Rathkopf, Agnes Viale, Michael F. Berger, David B. Solit
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background Cell-free DNA (cfDNA) profiling is increasingly used to guide cancer care, yet mutations are not always identified. The ability to detect somatic mutations in plasma depends on both assay sensitivity and the fraction of circulatin
Externí odkaz:
https://doaj.org/article/a175329a098b4151983ca7a727781ce0
Autor:
Marlon Stoeckius, Shiwei Zheng, Brian Houck-Loomis, Stephanie Hao, Bertrand Z. Yeung, William M. Mauck, Peter Smibert, Rahul Satija
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Despite rapid developments in single cell sequencing, sample-specific batch effects, detection of cell multiplets, and experimental costs remain outstanding challenges. Here, we introduce Cell Hashing, where oligo-tagged antibodies against u
Externí odkaz:
https://doaj.org/article/8f61de2b6f854615844e6e5b104c3bad
Autor:
Antonio Strillacci, Pasquale Sansone, Vinagolu K. Rajasekhar, Mesruh Turkekul, Vitaly Boyko, Fanli Meng, Brian Houck-Loomis, David Brown, Michael F. Berger, Ronald C. Hendrickson, Qing Chang, Elisa de Stanchina, Fresia Pareja, Jorge S. Reis-Filho, Ramya Segu Rajappachetty, Isabella Del Priore, Bo Liu, Yanyan Cai, Alex Penson, Chiara Mastroleo, Marjan Berishaj, Francesca Borsetti, Enzo Spisni, David Lyden, Sarat Chandarlapaty, Jacqueline Bromberg
Publikováno v:
NPJ breast cancer. 8(1)
Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone binding pocket is a widely
Autor:
Agnes Viale, Ellinor I.B. Peerschke, Michael Wutkowski, Brian Houck-Loomis, Michael F. Berger, Melissa S. Pessin, Aliaksandra Samoila, Jose Sosa, Jessica Padilla, Katelynd Vanness
Publikováno v:
The Journal of Applied Laboratory Medicine. 5:788-797
Background Cell-free DNA (cfDNA) analysis using peripheral blood represents an exciting, minimally invasive technology for cancer diagnosis and monitoring. The reliability of testing is dependent on the accuracy and sensitivity of specific molecular
Autor:
Brian Houck-Loomis, James Cownie, Emiliano Cocco, Elisa de Stanchina, Marc Ladanyi, Kevin Ebata, Ryan Ptashkin, Sandra Misale, Helen Won, Aliaksandra Samoila, Alexander Drilon, Michael F. Berger, Marissa Mattar, David M. Hyman, Juber Patel, Rona Yaeger, Sean Guzman, Richard B. Lanman, Romel Somwar, Alison M. Schram, Jaclyn F. Hechtman, Amanda Kulick, Rebecca J. Nagy, Maurizio Scaltriti, Sophie Shifman, Brian B. Tuch, Pedram Razavi, Eneda Toska, S. Duygu Selcuklu
Publikováno v:
Nature medicine
TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition1–8. With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any
Autor:
Marina Asher, Jason C. Chang, Yingqian Zhan, Natasha Rekhtman, Hirokazu Taniguchi, Richard Koche, Brian Houck-Loomis, Elisa de Stanchina, Triparna Sen, Charles M. Rudin, Fanli Meng, Irina Linkov, Jacklynn D. Egger, Umesh Bhanot, Nisargbhai S. Shah, Fathema Uddin, Shweta S. Chavan, Michael H.A. Roehrl, Helena A. Yu, Joseph M. Chan, Michael Offin, Viola Allaj, P. Manoj, Katia Ventura, J. Qiu, Jordana Ray-Kirton, Metamia Ciampricotti, Maysun Hasan, Andrew Chow, Álvaro Quintanal-Villalonga
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
Background Lineage plasticity, the ability to transdifferentiate among distinct phenotypic identities, facilitates therapeutic resistance in cancer. In lung adenocarcinomas (LUADs), this phenomenon includes small cell and squamous cell (LUSC) histolo
Autor:
Qing Chang, M. Turkekul, E. Spisni, Brian Houck-Loomis, Chiara Mastroleo, F. Borsetti, Fresia Pareja, David Lyden, Marjan Berishaj, M.F. Berger, Bo Liu, David N Brown, R. Segu Rajappachetty, Fanli Meng, Alexander V Penson, Jorge S. Reis-Filho, S Chandarlapaty, Jacqueline Bromberg, Pasquale Sansone, V. Boyko, A. Strillacci, E. De Stanchina, Ronald C. Hendrickson, V. R. Rajasekhar
Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone binding pocket is a widely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e53ecd1890b10adf42b0f673f833a772
https://doi.org/10.1101/2021.10.14.464262
https://doi.org/10.1101/2021.10.14.464262
Autor:
Charles M. Rudin, Daniel K. Wells, Taha Merghoub, P. Manoj, Triparna Sen, H. J. Woo, Marissa Mattar, Jennifer L. Sauter, Joy A. Pai, Hira Rizvi, Mark T.A. Donoghue, Viola Allaj, Matthew D. Hellmann, Ansuman T. Satpathy, Jamie E. Chaft, Nisargbhai S. Shah, Helen Won, Andrew J. Plodkowski, Marina K. Baine, E. De Stanchina, Fathema Uddin, Brian Houck-Loomis, Álvaro Quintanal-Villalonga, Jedd D. Wolchok, Andrew Chow, Joseph M. Chan
Paired T cell receptor and RNA single cell sequencing (scTCR/RNA-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scTCR/RNA-seq dataset of 162,062 single T cells from 31 tissue regions, including tumor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::972611c6bab01a045c5dec2909ec877c
https://doi.org/10.1101/2021.09.27.461389
https://doi.org/10.1101/2021.09.27.461389