Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Brian Hondowicz"'
1
Regulation of T Cell Activation and Tolerance by Phospholipase Cγ-1-Dependent Integrin Avidity Modulation
Autor: Qing-Hua Liu, Bruce D. Freedman, Jidong Zhang, Laurence A. Turka, Andrew D. Wells, Brian Hondowicz
Publikováno v: The Journal of Immunology. 170:4127-4133
Ag receptor engagement without costimulation induces a tolerant state in CD4+ T cells termed anergy. Anergic CD4+ T cells are primarily characterized by the inability to produce IL-2, but the biochemical basis for this functional defect is not comple
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d11fdd81c0d36b3e2f92251acdc619
https://doi.org/10.4049/jimmunol.170.8.4127
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2
Modulation of Kv Channel Expression and Function by TCR and Costimulatory Signals during Peripheral CD4+ Lymphocyte Differentiation
Autor: Bruce D. Freedman, Michael I. Kotlikoff, Katsuyuki Yui, Brian Hondowicz, Curtis Maier, Andrew D. Wells, Qing-Hua Liu, Laurence A. Turka, Bernd K. Fleischmann
Publikováno v: The Journal of Experimental Medicine
Ionic signaling pathways, including voltage-dependent potassium (Kv) channels, are instrumental in antigen-mediated responses of peripheral T cells. However, how Kv channels cooperate with other signaling pathways involved in T cell activation and di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007e253b94cdd98222230c220c0cd825
https://doi.org/10.1084/jem.20020381
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3
Influence of Parasite Load on the Ability of Type 1 T Cells To ControlLeishmania majorInfection
Autor: Brian Hondowicz, Phillip Scott
Publikováno v: Infection and Immunity. 70:498-503
BALB/c mice infected withLeishmania majordeveloped a type 2 immune response which failed to control parasite replication. We found thatscidmice that received splenocytes from BALB/c mice that had been infected for 3 weeks withL. major(a type 2 cell p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f009707aca3336031049140a0ea72103
https://doi.org/10.1128/iai.70.2.498-503.2002
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4
Maintenance of IL-12-responsive CD4+ T cells during a Th2 response inLeishmania major-infected mice
Autor: M. Merle Elloso, Audrey Y. Park, Brian Hondowicz, Phillip Scott
Publikováno v: European Journal of Immunology. 30:2007-2014
BALB / c and anti-IL-12-treated C3H mice infected with Leishmania major develop a Th2 cell response. However, in contrast to BALB / c mice, C3H mice treated transiently with an anti-IL-12 monoclonal antibody switch from a Th2 to a Th1 response and re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c248efcff169b6132c7c92cb29813c8b
https://doi.org/10.1002/1521-4141(200007)30:7<2007::aid-immu2007>3.0.co
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6
The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis
Autor: Cris S. Constantinescu, M. Merle Elloso, Phillip Scott, Maria Wysocka, Brian Hondowicz, Giorgio Trinchieri
Publikováno v: European Journal of Immunology. 28:2227-2233
IL-12 initiates the development of cell-mediated immunity by promoting the differentiation of naive T cells into the Th1 phenotype, and is essential in the development of a Th1 immune response to the intracellular protozoan parasite, Leishmania major
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a0c98be56d03a998929b6ddb7778f36
https://doi.org/10.1002/(sici)1521-4141(199807)28:07<2227::aid-immu2227>3.0.co
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8
Germinal-center derived, somatically hypermutated ­Plasmodium-specific IgM+ memory B cells are optimally responsive to a secondary blood stage malaria infection
Autor: Akshay T Krishnamurty, Chris Thouvenel, Brian Hondowicz, Gladys Keitany, Peter Crompton, David J Rawlings, Marion Pepper
Publikováno v: The Journal of Immunology. 196:134.9-134.9
Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells and rapidly reactive memory B cells (MBCs). Secondary responses by MBCs traditionally are thought to involve the production of class-switched, high affinity ant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d045b4449f4e339378edb3ca8fe725b
https://doi.org/10.4049/jimmunol.196.supp.134.9
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9
Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli
Autor: John G. Monroe, Xiaohong Liu, Leslie B. King, Qing-Hua Liu, Bruce D. Freedman, Brian Hondowicz, Zhiyun Wen
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 174(1)
Intracellular Ca2+ plays a central role in controlling lymphocyte function. Nonetheless, critical gaps remain in our understanding of the mechanisms that regulate its concentration. Although Ca2+-release-activated calcium (CRAC) channels are the prim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6759ecaa8162638058a7197e85e5b5f
https://pubmed.ncbi.nlm.nih.gov/15611229
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10
The role of IL-12 in maintaining resistance to Leishmania major
Autor: Phillip Scott, Audrey Y. Park, Manfred Kopf, Brian Hondowicz
Publikováno v: Scopus-Elsevier
IL-12p40 is required for the maintenance of resistance during Leishmania major infection. In this study, we addressed how IL-12 mediates this function. First, we demonstrated that both subunits of IL-12, p40 and p35, were required for continued resis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4dc21fbda2e3d37e84e17ec4f33bec
https://pubmed.ncbi.nlm.nih.gov/12023378
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